Mengtian Fan
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View article: ATG7-driven mitophagy in BMSC@CS hydrogel reprograms metabolism to boost bone regeneration
ATG7-driven mitophagy in BMSC@CS hydrogel reprograms metabolism to boost bone regeneration Open
View article: Estimating scenic beauty in Chinese villages: a novel approach based on 3D real scene models
Estimating scenic beauty in Chinese villages: a novel approach based on 3D real scene models Open
The color landscape is an essential aspect of each village, representing both natural scenery and human history. However, previous research has not provided a thorough and quantitative assessment of the color spatial pattern of regions and…
View article: Panaxatriol exerts anti-senescence effects and alleviates osteoarthritis and cartilage repair fibrosis by targeting UFL1
Panaxatriol exerts anti-senescence effects and alleviates osteoarthritis and cartilage repair fibrosis by targeting UFL1 Open
View article: 10-hydroxy-2-decenoic acid prevents osteoarthritis by targeting aspartyl β hydroxylase and inhibiting chondrocyte senescence in male mice preclinically
10-hydroxy-2-decenoic acid prevents osteoarthritis by targeting aspartyl β hydroxylase and inhibiting chondrocyte senescence in male mice preclinically Open
View article: Targeting the senescence-related genes MAPK12 and FOS to alleviate osteoarthritis
Targeting the senescence-related genes MAPK12 and FOS to alleviate osteoarthritis Open
The translation potential of this article is that we revealed MAPK12 and FOS can effectively alleviate OA by regulating chondrocyte senescence, and thus provided potential therapeutic targets for prevention or treatment of OA in the future.
View article: The circUbqln1, regulated by XBP1s, interplays with 14–3–3ζ to inhibit collagen synthesis and promote osteoarthritis by controlling PRODH activity and proline metabolism
The circUbqln1, regulated by XBP1s, interplays with 14–3–3ζ to inhibit collagen synthesis and promote osteoarthritis by controlling PRODH activity and proline metabolism Open
CircUbqln1 plays a crucial role in the occurrence and development of OA, indicating that the inhibition of circUbqln1 holds promise as a significant approach for treating OA in the future.
View article: IRE1α protects against osteoarthritis by regulating progranulin-dependent XBP1 splicing and collagen homeostasis
IRE1α protects against osteoarthritis by regulating progranulin-dependent XBP1 splicing and collagen homeostasis Open
Osteoarthritis (OA) is a full-joint, multifactorial, degenerative and inflammatory disease that seriously affects the quality of life of patients due to its disabling and pain-causing properties. ER stress has been reported to be closely r…
View article: Gut-joint axis: Oral Probiotic ameliorates Osteoarthritis
Gut-joint axis: Oral Probiotic ameliorates Osteoarthritis Open
View article: IRE1α regulates the PTHrP-IHH feedback loop to orchestrate chondrocyte hypertrophy and cartilage mineralization
IRE1α regulates the PTHrP-IHH feedback loop to orchestrate chondrocyte hypertrophy and cartilage mineralization Open
Cartilage development is controlled by the highly synergistic proliferation and differentiation of growth plate chondrocytes, in which the Indian hedgehog (IHH) and parathyroid hormone-related protein-parathyroid hormone-1 receptor (PTHrP-…
View article: Progranulin regulation of autophagy contributes to its chondroprotective effect in osteoarthritis
Progranulin regulation of autophagy contributes to its chondroprotective effect in osteoarthritis Open
Progranulin (PGRN) is a multifunctional growth factor involved in many physiological processes and disease states. The apparent protective role of PGRN and the importance of chondrocyte autophagic function in the progression of osteoarthri…
View article: Effect Of XBP1 Deficiency In Cartilage On The Regulatory Network Of LncRNA/circRNA-miRNA-mRNA
Effect Of XBP1 Deficiency In Cartilage On The Regulatory Network Of LncRNA/circRNA-miRNA-mRNA Open
X-box binding protein 1(XBP1) is a critical component for unfolded protein response (UPR) in ER stress. According to previous studies performed with different XBP1-deficient mice, the XBP1 gene affects mouse cartilage development an…
View article: PGRN exacerbates the progression of non-small cell lung cancer via PI3K/AKT/Bcl-2 antiapoptotic signaling
PGRN exacerbates the progression of non-small cell lung cancer via PI3K/AKT/Bcl-2 antiapoptotic signaling Open
View article: CX<sub>3</sub>CL1 promotes tumour cell by inducing tyrosine phosphorylation of cortactin in lung cancer
CX<sub>3</sub>CL1 promotes tumour cell by inducing tyrosine phosphorylation of cortactin in lung cancer Open
It has been reported that chemokine CX 3 CL1 can regulate various tumours by binding to its unique receptor CX 3 CR1. However, the effect of CX 3 CL1‐CX 3 CR1 on the lung adenocarcinoma and lung squamous cell carcinoma is still unclear. He…
View article: Benzo[a]pyrene injures BMP2-induced osteogenic differentiation of mesenchymal stem cells through AhR reducing BMPRII
Benzo[a]pyrene injures BMP2-induced osteogenic differentiation of mesenchymal stem cells through AhR reducing BMPRII Open
Benzo[a]pyrene(BaP), a polycyclic aromatic hydrocarbons (PAH) of environmental pollutants, is one of the main ingredients in cigarettes and an agonist of the aryl hydrocarbon receptor (AhR). Mesenchymal stem cells (MSCs) including C3H10T1/…
View article: Ciprofloxacin promotes polarization of CD86+CD206‑ macrophages to suppress liver cancer
Ciprofloxacin promotes polarization of CD86+CD206‑ macrophages to suppress liver cancer Open
Gut microbiota can promote tumor development by producing toxic metabolites and inhibiting the function of immune cells. Previous studies have demonstrated that gut microbiota can reach the liver through the circulation and promote the occ…
View article: CX3CR1 regulates hepatocellular carcinoma(HCC) metastasis via PI3K/AKT pathway
CX3CR1 regulates hepatocellular carcinoma(HCC) metastasis via PI3K/AKT pathway Open
Background Fractalkine receptor CX3CR1 is differentially expressed in hepatocellular carcinoma and its function is unknown. As a special case of chemokine family, CX3CR1 only binds to its unique ligand CX3CL1, and CX3CL1 also only binds to…
View article: MicroRNA-155 inhibits the osteogenic differentiation of mesenchymal stem cells induced by BMP9 via downregulation of BMP signaling pathway
MicroRNA-155 inhibits the osteogenic differentiation of mesenchymal stem cells induced by BMP9 via downregulation of BMP signaling pathway Open
Previous studies have indicated that bone morphogenetic protein 9 (BMP9) can promote the osteogenic differentiation of mesenchymal stem cells (MSCs) and increase bone formation in bone diseases. However, the mechanisms involved remained po…
View article: BMP9 inhibits the growth and migration of lung adenocarcinoma A549 cells in a bone marrow stromal cell-derived microenvironment through the MAPK/ERK and NF-κB pathways
BMP9 inhibits the growth and migration of lung adenocarcinoma A549 cells in a bone marrow stromal cell-derived microenvironment through the MAPK/ERK and NF-κB pathways Open
Bone is the most common distant metastatic site of lung cancer, and is particularly prone to osteolytic damage. Soluble factors secreted from bone marrow-derived cells and tumor cells contribute to the growth and metastasis of cancer cells…