Explanipedia

A TtAgo‐Driven Autocatalytic Circuit with Thermal‐Enhanced Kinetics for One‐Pot Nucleic Acid Detection Open

Zuowei Xie, Ruijia Deng, Ben Niu, Yingjie Yang, Shuang Zhao , et al. · 2025

Catalytic DNA circuits hold significant promise for nucleic‐acid‐based diagnostics, yet they remain hindered by slow reaction kinetics and the non‐universal nature of one‐pot approaches. Here, a universal catalytic DNA circuits termed TACT…

Boosting Pre-trained Model with Silica Nanoparticles Cellular Toxicity Prediction Open

Huixia Zhang, Jiajun Tong, Ming Chen, Xichuan Cao · 2025

Silica nanoparticles have been widely adopted as carriers for drug delivery and components of multifunctional nanocomposites, but potentially lead to off-target accumulation and subsequent cytotoxic effects. Previous works explored data-dr…

Nanotechnology for the treatment of atherosclerosis: Strategies, practical applications and future perspectives Open

Ying Zhang, Zheng Chai, Ming Chen, Shufen Li, Weihua Zhuang , et al. · 2025

Real time wire rope detection method based on Rockchip RK3588 Open

Ming Qian, Yong Wang, Siyuan Liu, Zhanghou Xu, Zhenshan Ji , et al. · 2025

Radionuclide-labeled nanomaterials for tumor therapy: Recent progress and perspectives Open

Zhiming Zhen, Feng Liu, He Liu, Ming Chen, Jianhuai Chen , et al. · 2025

Radionuclide therapy (RNT) uses the ionizing radiation generated by the emitted particles during radioactive decay to directly damage DNA structure or indirectly increase the concentration of free radicals in cells, thereby destroying or k…

Plasma DNMT1 Activity for Assessing Tumor Burden and Predicting Neoadjuvant Therapy Response in Breast Cancer (Adv. Sci. 31/2025) Open

Yingran Wang, Guozhi Zhang, Zhizhao Zhang, Mengsi Zhang, Jiao Chen , et al. · 2025

Targeting Dio3 to enhance mitophagy and ameliorate skeletal muscle wasting in sepsis Open

Gang Wang, Ming Chen, Yuheng Zhang, Dacheng Wang, Tao Gao , et al. · 2025

The Oxytocin Neurons in the Paraventricular Nucleus Are Essential for Chronic Sleep Deprivation‐Mediated Anxiety‐Related Behaviors Open

Yuxin Wang, Yifei Zhang, Yanchao Liu, Zhendong Xu, Jiyan Zhang , et al. · 2025

Aims Sleep disorders increase the risk of anxiety disorders. The underlying mechanisms and potential targets remain poorly understood. Our research aimed to discover the essential role of oxytocin neurons in the paraventricular nucleus (PV…

Hollow mesoporous silica nano-delivery systems based on ultra-thin biodegradable shells a synergistic integration strategy for chemotherapy and photothermal therapy Open

Huixia Zhang, Yan Zhang, Zhu Diao, Ming Chen, Xichuan Cao · 2025

Mesoporous silica nanoparticles (MSNs) have been discovered to hold substantial potential in tumor treatment due to their ability to enhance drug tumor-targeting capacity and reduce side effects as a nanoparticle drug delivery system. We r…

Plasma DNMT1 Activity for Assessing Tumor Burden and Predicting Neoadjuvant Therapy Response in Breast Cancer Open

Yingran Wang, Guozhi Zhang, Zhizhao Zhang, Mengsi Zhang, Jiao Chen , et al. · 2025

DNA methylation is mediated by DNA methyltransferases (DNMTs), and the stability of their activity is essential for cellular fate. DNMT1 is considered one of the most promising targets for research. However, current detection techniques ar…

The Role of Oxytocin Neurons in the Paraventricular Nucleus in Chronic-Sleep-Deprivation-Mediated Abnormal Cardiovascular Responses Open

Yifei Zhang, Yuxin Wang, Zhendong Xu, Xiangjie Kong, Hairong Wang , et al. · 2025

Sleep disorders increase the risk of cardiovascular diseases. However, the underlying mechanisms remain unclear. This study aims to examine the critical role of oxytocin neurons in the paraventricular nucleus (PVNOXT) in regulating the car…

DNA nanorobot for mitochondria-targeted microRNAs detection and tailored regulation Open

Ping Huang, Xiaoqi Tang, Shuang Zhao, Jie Luo, Yu Tang , et al. · 2025

Rationale: Mitochondrial miRNAs (mitomiRs) are crucial regulators of mitochondrial functions and play pivotal roles in tumorigenesis and cancer progression. Nevertheless, direct monitoring mitomiRs and regulating mitochondrial funct…

Ultra-low temperature stacking fault energy control and deformation mechanism of high-Mn austenitic steel Open

Feng Hu, Zhihong Zhong, Ming Chen, X.F. Kong, Tongliang Wang , et al. · 2025

Abiotic stress-induced changes in Tetrastigma hemsleyanum: insights from secondary metabolite biosynthesis and enhancement of plant defense mechanisms Open

Ming Chen, Xiaoqun Wang, Xiaofeng Zhou, Bo Huang, Yujie Zhao , et al. · 2024

Developing Cryptic ACTL6B as Novel TDP‐43 Loss of Function Biomarker Open

Ming Chen, Katherine E. Irwin, Koping Chang, Pei Jasin, Kerstin E. Braunstein , et al. · 2024

Background The nuclear clearance and cytoplasmic aggregation of splicing repressor TAR DNA/RNA‐binding protein‐43 (TDP‐43) occur in approximately 50% of Alzheimer’s disease (AD) cases and about 45% of frontotemporal dementia (FTD). However…

miR-Cabiner: A universal microRNA sensing platform based on self- stacking cascaded bicyclic DNA circuit-mediated CRISPR/Cas12a Open

Ruijia Deng, Jing Sheng, Zuowei Xie, Hongzhao Yang, Sha Yang , et al. · 2024

Background CRISPR/Cas12a-based diagnostics enable great potential in the sensing nucleic acid, but its application was limited by the sequence dependence. Results A platform termed miR-Cabiner (a universal miRNA sensing platform based on s…

Current landscape of exosomal non-coding RNAs in prostate cancer: Modulators and biomarkers Open

Yongxing Li, Xiaoqi Tang, Binpan Wang, Ming Chen, Ji Zheng , et al. · 2024

Integrating Pt nanoparticles with 3D Cu2-xSe/GO nanostructure to achieve nir-enhanced peroxidizing Nano-enzymes for dynamic monitoring the level of H2O2 during the inflammation Open

Man Shen, Xianling Dai, Demchenko N.N., Hanqing Xu, Yang Zhou , et al. · 2024

The treatment of wound inflammation is intricately linked to the concentration of reactive oxygen species (ROS) in the wound microenvironment. Among these ROS, H 2 O 2 serves as a critical signaling molecule and second messenger, necessita…

Recent progress of iron-based nanomaterials in gene delivery and tumor gene therapy Open

Ya Gong, Xiao Hu, Ming Chen, Jun Wang · 2024

Gene therapy aims to modify or manipulate gene expression and change the biological characteristics of living cells to achieve the purpose of treating diseases. The safe, efficient, and stable expression of exogenous genes in cells is cruc…

Single-nucleus multi-omic profiling of polyploid heart nuclei identifies fusion-derived cardiomyocytes in the human heart. Open

Sangita Choudhury, Indu Sivankutty, Youngsook L. Jung, August Yue Huang, Sarah Araten , et al. · 2024

Understanding the mechanisms of polyploidization in cardiomyocytes is crucial for advancing strategies to stimulate myocardial regeneration. Although endoreplication has long been considered the primary source of polyploid human cardiomyoc…

Multiarmed DNA jumper and metal-organic frameworks–functionalized paper-based bioplatform for small extracellular vesicle–derived miRNAs assay Open

Xiaopei Qiu, Huisi Yang, Man Shen, Hanqing Xu, Yingran Wang , et al. · 2024

Small extracellular vesicle–derived microRNAs (sEV-miRNAs) have emerged as promising noninvasive biomarkers for early cancer diagnosis. Herein, we developed a molecular probe based on three-dimensional (3D) multiarmed DNA tetrahedral jumpe…

Autonomous Feedback-Driven Engineered DNAzyme-Coated Trojan Horse-like Nanocapsules for On-Demand CRISPR/Cas9 Delivery Open

Xiaoqi Tang, Yihui Chen, Binpan Wang, Dan Luo, Jue Wang , et al. · 2024

Manipulating the expression of cellular genes through efficient CRISPR/Cas9 delivery is rapidly evolving into a desirable tumor therapeutics. The exposure of CRISPR/Cas9 to a complex external environment poses challenges for conventional d…

Dumbbell Dual-Hairpin Triggered DNA Nanonet Assembly for Cascade-Amplified Sensing of Exosomal MicroRNA Open

Yongxing Li, Xiaoqi Tang, Ruijia Deng, Liu Feng, Shuang Xie , et al. · 2024

Exosomal microRNAs (miRNAs) are valuable biomarkers closely associated with cancer progression. Therefore, sensitive and specific exosomal miRNA biosensing has been employed for cancer diagnosis, prognosis, and prediction. In this study, a…

Lopinavir enhances anoikis by remodeling autophagy in a circRNA-dependent manner Open

Yaran Wu, Yang Chen, Xiaojing Yan, Xufang Dai, Yaling Liao , et al. · 2024

Macroautophagy/autophagy-mediated anoikis resistance is crucial for tumor metastasis. As a key autophagy-related protein, ATG4B has been demonstrated to be a prospective anti-tumor target. However, the existing ATG4B inhibitors are still f…

CRISPR/Cas12a‐loaded intelligent DNA hydrogel for universal and ultrasensitive exosome assay Open

Jie Luo, Binpan Wang, Xiaoqi Tang, Ping Huang, Sha Yang , et al. · 2024

Tumor‐derived exosomes are crucial for early non‐invasive and accurate tumor diagnosis in clinical diagnostics. The development of highly sensitive, simple, and intuitive exosome assays has sparked a research upsurge in clinical diagnostic…

Bottom‐up DNA nanostructure‐based paper as point‐of‐care diagnostic: From method to device Open

Xueping Gao, Feng Liu, Ruijia Deng, Binpan Wang, Yuan He , et al. · 2024

Paper‐based devices have attracted considerable attention in point‐of‐care testing (POCT) due to their simple operation and portability. The performance of paper‐based POC assays is further enhanced by coupling with functional nucleic acid…

A Universal Strategy for Enhancing the Circulating miRNAs’ Detection Performance of Rolling Circle Amplification by Using a Dual-Terminal Stem-Loop Padlock Open

Hanqing Xu, Xianlan Wu, Qian Liu, Yang Cheng, Man Shen , et al. · 2023

Rolling circle amplification (RCA) is one of the most promising nucleic acid detection technologies and has been widely used in the molecular diagnosis of disease. Padlock probes are often used to form circular templates, which are the cor…

Smart Tumor Cell‐Derived DNA Nano‐Tree Assembly for On‐Demand Macrophages Reprogramming Open

Zhiguo Chen, Sha Yang, Zhuyang Zhao, Feng Liu, Jing Sheng , et al. · 2023

Without coordinated strategies to balance the population and activity of tumor cells and polarized macrophages, antitumor immunotherapy generally offers limited clinical benefits. Inspired by the “eat me” signal, a smart tumor cell‐derived…

CRISPR/Cas12a-Loaded intelligent DNA hydrogel for Universal and Ultrasensitive Exosome Assay Open

Jie Luo, Binpan Wang, Xiaoqi Tang, Ping Huang, Sha Yang , et al. · 2023

Tumor-derived exosomes are crucial for early non-invasive and accurate tumor diagnosis in clinical. The development of highly sensitive, simple and intuitive exosome assays has sparked a research upsurge in clinical diagnostics. Here, we d…

Multiarmed DNA jumper and Metal-Organic Frameworks–Functionalized Paper-based Bioplatform for Small Extracellular Vesicle–derived miRNAs Assay Open

Xiaopei Qiu, Huisi Yang, Man Shen, Hanqing Xu, Yingran Wang , et al. · 2023

Small extracellular vesicle–derived microRNAs (sEV-miRNAs) have emerged as promising noninvasive biomarkers for early cancer diagnosis. Herein, we developed a molecular probe based on three-dimensional (3D) multiarmed DNA tetrahedral jumpe…

Ming Chen YOU? Author Swipe