Ming‐Kuei Lu
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View article: Species‐level exploration of the gut microbiome in the leaf‐eating <i>Presbytis</i> monkeys reflected the effects of anthropogenic activity and specialized dietary niches: Conservation on the fourth biodiversity level
Species‐level exploration of the gut microbiome in the leaf‐eating <i>Presbytis</i> monkeys reflected the effects of anthropogenic activity and specialized dietary niches: Conservation on the fourth biodiversity level Open
Seventy‐five percent of nonhuman primates have declining populations caused by deforestation and habitat loss, mainly due to human disturbance worldwide. Endangered white‐headed langurs and François' langurs are two allopatric species inha…
View article: Immediate Motor Control Enhancement via Pallidothalamic Tract (<scp>PTT</scp>) Circuit Ablation: A Dual‐Target <scp>MR</scp>‐Guided Focused Ultrasound Approach for Tremor‐Dominant Parkinson's Disease
Immediate Motor Control Enhancement via Pallidothalamic Tract (<span>PTT</span>) Circuit Ablation: A Dual‐Target <span>MR</span>‐Guided Focused Ultrasound Approach for Tremor‐Dominant Parkinson's Disease Open
Background Stepwise dual‐target MR‐guided Focused Ultrasound (dtMRgFUS) is a novel treatment for Parkinson's disease (PD), targeting both Ventral Intermediate Nucleus (VIM) and the pallidothalamic tract (PTT). While previous studies have d…
View article: Effectiveness of a booster dose of aerosolized or intramuscular adenovirus type 5 vectored COVID-19 vaccine in adults: a multicenter, partially randomized, platform trial in China
Effectiveness of a booster dose of aerosolized or intramuscular adenovirus type 5 vectored COVID-19 vaccine in adults: a multicenter, partially randomized, platform trial in China Open
We conducted a multicenter, partially randomized, platform trial to assess the effectiveness of a booster dose of an aerosolized or intramuscular adenovirus type 5 vectored COVID-19 vaccine (Ad5-nCoV) in Chinese adults (NCT05855408). Betwe…
View article: Identifying Pyroptosis-Hub Genes and Inflammation Cell Type-Related Genes in Ischemic Stroke
Identifying Pyroptosis-Hub Genes and Inflammation Cell Type-Related Genes in Ischemic Stroke Open
View article: Association between Scabies Treatment and Parkinson’s Disease: A Nationwide, Population-Based Study
Association between Scabies Treatment and Parkinson’s Disease: A Nationwide, Population-Based Study Open
Background: Scabies is typically treated with scabicides like lindane, which poses a risk for acute neural toxicity. Lindane’s prolonged use, particularly in agriculture, is linked to neurodegenerative diseases, including Parkinson’s disea…
View article: Stepwise dual‐target <scp>magnetic resonance</scp>‐guided focused ultrasound in tremor‐dominant Parkinson disease: One‐year follow‐up
Stepwise dual‐target <span>magnetic resonance</span>‐guided focused ultrasound in tremor‐dominant Parkinson disease: One‐year follow‐up Open
Background and Purpose Magnetic resonance‐guided focused ultrasound (MRgFUS) is a nonsurgical treatment for Parkinson disease (PD). Some selected anatomical structures can be targeted by MRgFUS in PD. However, there is no uniform target ye…
View article: Automated delineation of acute ischemic stroke lesions on non-contrast CT using 3D deep learning: A promising step towards efficient diagnosis and treatment
Automated delineation of acute ischemic stroke lesions on non-contrast CT using 3D deep learning: A promising step towards efficient diagnosis and treatment Open
We adopt the existing Deep learning architecture to support diagnosing acute ischemic stroke by automatically detecting lesion location on 3D non-contrast CT brain scans. We also investigate the feasibility of the model's applications in t…
View article: The Rehabilitative Effect of Archery Exercise Intervention in Patients with Parkinson’s Disease
The Rehabilitative Effect of Archery Exercise Intervention in Patients with Parkinson’s Disease Open
Background. Archery exercise exerts a rehabilitative effect on patients with paraplegia and might potentially serve as complementary physiotherapy for patients with Parkinson’s disease. Objective. This study aimed to examine the rehabilita…
View article: Electroacupuncture on Modifying Inflammatory Levels of Cytokines and Metabolites in Stroke Patients
Electroacupuncture on Modifying Inflammatory Levels of Cytokines and Metabolites in Stroke Patients Open
Introduction The use of electroacupuncture (EA) in post-ischemic stroke and rehabilitation has been the subject of numerous studies; however, the effect of EA on cholesterol metabolites has not been thoroughly investigated. The inflammator…
View article: Substance Misuse Decreases Heart Rate Variability
Substance Misuse Decreases Heart Rate Variability Open
There are few biomarkers to reflect the physiological conditions for substance misuse. In this study, autonomic nervous and cardiovascular parameters were measured for participants in deferred prosecution programs. The goal of this study i…
View article: The neuromuscular responses in patients with Parkinson’s disease under different conditions during whole-body vibration training
The neuromuscular responses in patients with Parkinson’s disease under different conditions during whole-body vibration training Open
View article: Transient receptor potential V1 modulates neuroinflammation in Parkinson's disease dementia: Molecular implications for electroacupuncture and rivastigmine.
Transient receptor potential V1 modulates neuroinflammation in Parkinson's disease dementia: Molecular implications for electroacupuncture and rivastigmine. Open
Our results showed that TRPV1 played a role in the modulation of neuroinflammation of PDD, and could potentially be a new target for treatment.
View article: Gait-Related Brain Activation During Motor Imagery of Complex and Simple Ambulation in Parkinson's Disease With Freezing of Gait
Gait-Related Brain Activation During Motor Imagery of Complex and Simple Ambulation in Parkinson's Disease With Freezing of Gait Open
Background: Freezing of gait (FOG) in Parkinson's disease (PD) is a devastating clinical phenomenon that has a detrimental impact on patients. It tends to be triggered more often during turning (complex) than during forwarding straight (si…
View article: Low-frequency oscillations in cortical level to help diagnose task-specific dystonia
Low-frequency oscillations in cortical level to help diagnose task-specific dystonia Open
View article: Bereitschaftspotential in Multiple System Atrophy
Bereitschaftspotential in Multiple System Atrophy Open
Objective: Multiple system atrophy (MSA) is a neurodegenerative disorder manifesting as parkinsonism, cerebellar ataxia, and autonomic dysfunction. It is categorized into MSA with predominant parkinsonism (MSA-P) and into MSA with predomin…
View article: Use of a Smartphone Application to Speed Up Interhospital Transfer of Acute Ischemic Stroke Patients for Thrombectomy
Use of a Smartphone Application to Speed Up Interhospital Transfer of Acute Ischemic Stroke Patients for Thrombectomy Open
Background: In most countries, large cerebral artery occlusion is identified as the leading cause of disability. In 2015, five large-scale clinical trials confirmed the benefit of intra-arterial thrombectomy. However, thrombectomy is a hig…
View article: Personalization of Repetitive Transcranial Magnetic Stimulation for the Treatment of Major Depressive Disorder According to the Existing Psychiatric Comorbidity
Personalization of Repetitive Transcranial Magnetic Stimulation for the Treatment of Major Depressive Disorder According to the Existing Psychiatric Comorbidity Open
Repetitive transcranial magnetic stimulation (rTMS) and intermittent theta-burst stimulation (iTBS) are evidenced-based treatments for patients with major depressive disorder (MDD) who fail to respond to standard first-line therapies. Howe…
View article: Changes in Balance, Gait and Electroencephalography Oscillations after Robot-Assisted Gait Training: An Exploratory Study in People with Chronic Stroke
Changes in Balance, Gait and Electroencephalography Oscillations after Robot-Assisted Gait Training: An Exploratory Study in People with Chronic Stroke Open
Robot-assisted gait training (RAGT) systems offer the advantages of standard rehabilitation and provide precise and quantifiable control of therapy. We examined the clinical outcome of RAGT and analyzed the correlations between gait analys…
View article: Convergent Associative Motor Cortical Plasticity Induced by Conditional Somatosensory and Motor Reaction Afferents
Convergent Associative Motor Cortical Plasticity Induced by Conditional Somatosensory and Motor Reaction Afferents Open
Objective: Associative motor cortical plasticity can be non-invasively induced by paired median nerve electric stimulation and transcranial magnetic stimulation (TMS) of the primary motor cortex (M1). This study investigates whether…
View article: The Neurologic Manifestations of Coronavirus Disease 2019 Pandemic: A Systemic Review
The Neurologic Manifestations of Coronavirus Disease 2019 Pandemic: A Systemic Review Open
Objective: Review and integrate the neurologic manifestations of the Coronavirus Disease 2019 (COVID-19) pandemic, to aid medical practitioners who are combating the newly derived infectious disease. Methods: We reviewed the …
View article: Impairments in face discrimination and emotion recognition are related to aging and cognitive dysfunctions in Parkinson’s disease with dementia
Impairments in face discrimination and emotion recognition are related to aging and cognitive dysfunctions in Parkinson’s disease with dementia Open
Patients with Parkinson’s disease (PD) suffer from motor and non-motor symptoms; 40% would develop dementia (PD-D). Impaired face and emotion processing in PD has been reported; however, the deficits of face processing in PD-D remain uncle…
View article: Event-Related Desynchronization/Synchronization in Spinocerebellar Ataxia Type 3
Event-Related Desynchronization/Synchronization in Spinocerebellar Ataxia Type 3 Open
Introduction: Spinocerebellar ataxia type 3 (SCA3) is an autosomal dominant, cerebellar degeneration predominant disease caused by excessive CAG repeats. We examined event-related dysynchronization/synchronization (ERD/ERS) in patie…
View article: Peripheral trauma and risk of dystonia: What are the evidences and potential co-risk factors from a population insurance database?
Peripheral trauma and risk of dystonia: What are the evidences and potential co-risk factors from a population insurance database? Open
These data from a large population dataset support traumatic injury as a risk factor for the development of dystonia.
View article: Paired Associative Electroacupuncture and Transcranial Magnetic Stimulation in Humans
Paired Associative Electroacupuncture and Transcranial Magnetic Stimulation in Humans Open
Pairing transcutaneous electric nerve stimulation (TENS) and transcranial magnetic stimulation (TMS) with specific stimulus-intervals induces associative motor plasticity at the primary motor cortex (M1). Electroacupuncture (EA) is an esta…
View article: Impaired Cerebellum to Primary Motor Cortex Associative Plasticity in Parkinson’s Disease and Spinocerebellar Ataxia Type 3
Impaired Cerebellum to Primary Motor Cortex Associative Plasticity in Parkinson’s Disease and Spinocerebellar Ataxia Type 3 Open
Corticocortical CB → M1 PAS can induce bidirectional motor cortical plasticity in M1 for healthy aged subjects. The modulation may be independent of the inhibitory neurocircuits, such as SICI and CBI, and the facilitatory mechanism like IC…
View article: Investigation of Motor Cortical Plasticity and Corticospinal Tract Diffusion Tensor Imaging in Patients with Parkinsons Disease and Essential Tremor
Investigation of Motor Cortical Plasticity and Corticospinal Tract Diffusion Tensor Imaging in Patients with Parkinsons Disease and Essential Tremor Open
Parkinson's disease (PD) and essential tremor (ET) are characterized with motor dysfunctions. Motor circuit dysfunctions can be complementarily investigated by paired associative stimulation (PAS)-induced long-term potentiation (LTP)-like …
View article: Augmenting LTP-Like Plasticity in Human Motor Cortex by Spaced Paired Associative Stimulation
Augmenting LTP-Like Plasticity in Human Motor Cortex by Spaced Paired Associative Stimulation Open
Paired associative stimulation (PASLTP) of the human primary motor cortex (M1) can induce LTP-like plasticity by increasing corticospinal excitability beyond the stimulation period. Previous studies showed that two consecutive PASLTP proto…
View article: Connectivity of Pedunculopontine and Sub-thalamic nuclei in Parkinson’s disease
Connectivity of Pedunculopontine and Sub-thalamic nuclei in Parkinson’s disease Open