Mengzhe Zhang
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View article: Cerebellar-mediated imbalance of multiple neural circuits in internet gaming disorder: A multi-voxel pattern and granger causality analysis
Cerebellar-mediated imbalance of multiple neural circuits in internet gaming disorder: A multi-voxel pattern and granger causality analysis Open
View article: Functional Connectivity Disruptions in Grey Matter Volume‐Altered Brain Regions Among Male Smokers: A Neuroimaging Study
Functional Connectivity Disruptions in Grey Matter Volume‐Altered Brain Regions Among Male Smokers: A Neuroimaging Study Open
This study aimed to investigate whether structural brain alterations in smokers are accompanied by synchronized changes in functional connectivity, with a focus on understanding the neural mechanisms underlying smoking addiction. We conduc…
View article: Ursolic acid suppresses gastric cancer by targeting the miR-27a-3p/Wnt/β-catenin signaling axis
Ursolic acid suppresses gastric cancer by targeting the miR-27a-3p/Wnt/β-catenin signaling axis Open
View article: 109 Multicenter exploration of clinical, imaging, and immunological predictors for pCR and MPR in NSCLC neoadjuvant chemoimmunotherapy
109 Multicenter exploration of clinical, imaging, and immunological predictors for pCR and MPR in NSCLC neoadjuvant chemoimmunotherapy Open
View article: 480 Targeting CHCHD3 – cGAS axis: a strategy to remodel the immunosuppressive microenvironment in lung adenocarcinoma with translational implications
480 Targeting CHCHD3 – cGAS axis: a strategy to remodel the immunosuppressive microenvironment in lung adenocarcinoma with translational implications Open
View article: Correlation of N-acetylaspartyl glutamate level in the medial prefrontal cortex with FTND and daily smoking amounts in adult cigarette smokers
Correlation of N-acetylaspartyl glutamate level in the medial prefrontal cortex with FTND and daily smoking amounts in adult cigarette smokers Open
Background The neurotransmitter excitation/inhibition (E/I) balance is critical for maintaining normal brain function, and the contribution of nicotine signaling to homeostasis regulation and maintenance of E/I ratios is only beginning to …
View article: Comparison of respiratory pathogen infections in hospitalized patients before and during the COVID-19 pandemic in Shanghai, China
Comparison of respiratory pathogen infections in hospitalized patients before and during the COVID-19 pandemic in Shanghai, China Open
This study aimed to assess the impact of COVID-19 on the prevalence of respiratory pathogens among hospitalized patients with respiratory tract infections in Shanghai, China. Patients with acute respiratory infections (ARIs) hospitalized a…
View article: Abnormal resting-state effective connectivity of triple network predicts smoking motivations among males
Abnormal resting-state effective connectivity of triple network predicts smoking motivations among males Open
Background The causal or direct connectivity alterations of triple network including salience network (SN), central executive network (CEN), and default mode network (DMN) in tobacco use disorder (TUD) and the neurobiological features asso…
View article: Altered inter-hemispheric and intra-hemispheric functional connectivity dynamics in male cigarette smokers
Altered inter-hemispheric and intra-hemispheric functional connectivity dynamics in male cigarette smokers Open
This study revealed shared inter/intra-hemispheric dFCD variability of visual cortex, and different connection patterns of frontoparietal control network and insula at hemisphere level in smokers. These findings supply novel insights into …
View article: Mitochondrial Pathway Signature (MitoPS) predicts immunotherapy response and reveals NDUFB10 as a key immune regulator in lung adenocarcinoma
Mitochondrial Pathway Signature (MitoPS) predicts immunotherapy response and reveals NDUFB10 as a key immune regulator in lung adenocarcinoma Open
Background Lung adenocarcinoma (LUAD) is the most common subtype of non-small cell lung cancer. Although immune checkpoint inhibitors (ICIs) have brought new treatment options for advanced patients, a considerable proportion still shows li…
View article: Abnormal intrahemispheric and interhemispheric dynamic functional connectivity density in male alcohol use disorder
Abnormal intrahemispheric and interhemispheric dynamic functional connectivity density in male alcohol use disorder Open
Background Previous studies have demonstrated abnormal static intrahemispheric and interhemispheric functional connectivity between different brain regions in patients with alcohol use disorder (AUD). However, brain activity is highly dyna…
View article: The structural and functional brain alternations in tobacco use disorder: a systematic review and meta-analysis
The structural and functional brain alternations in tobacco use disorder: a systematic review and meta-analysis Open
Background While numerous previous studies have indicated that nicotine intake results in gray matter and functional brain abnormalities in tobacco use disorder (TUD), the majority of results could not be replicated or even reversed. Conse…
View article: Multicenter evaluation of predictive clinical and imaging factors for pathological response in non-small cell lung cancer patients treated with neoadjuvant chemotherapy and immune checkpoint inhibitors
Multicenter evaluation of predictive clinical and imaging factors for pathological response in non-small cell lung cancer patients treated with neoadjuvant chemotherapy and immune checkpoint inhibitors Open
View article: Habitat radiomics analysis for progression free survival and immune-related adverse reaction prediction in non-small cell lung cancer treated by immunotherapy
Habitat radiomics analysis for progression free survival and immune-related adverse reaction prediction in non-small cell lung cancer treated by immunotherapy Open
By leveraging machine learning to predict the outcomes of ICIs, we can move closer to achieving tailored ICIs for lung cancer. This advancement will assist physicians in selecting and managing subsequent treatment strategies, thereby facil…
View article: Effective connectivity of default mode network subsystems and automatic smoking behaviour among males
Effective connectivity of default mode network subsystems and automatic smoking behaviour among males Open
Background The default mode network (DMN) is not a single system, but rather is composed of smaller and distinct functional subsystems that interact with each other. The functional relevance of these subsystems in tobacco use disorder (TUD…
View article: Habitat Radiomics Analysis for Progression Free Survival and Immune-related Adverse Reaction Prediction in Non-small Cell Lung Cancer Treated by Immunotherapy
Habitat Radiomics Analysis for Progression Free Survival and Immune-related Adverse Reaction Prediction in Non-small Cell Lung Cancer Treated by Immunotherapy Open
Background Non-small cell lung cancer (NSCLC) is highly heterogeneous, leading to varied treatment responses and immune-related adverse reactions (irAEs) among patients. Habitat radiomics allows non-invasive quantitative assessment of intr…
View article: Static and temporal dynamic changes of intrinsic brain activity in early-onset and adult-onset schizophrenia: a fMRI study of interaction effects
Static and temporal dynamic changes of intrinsic brain activity in early-onset and adult-onset schizophrenia: a fMRI study of interaction effects Open
Background Schizophrenia is characterized by altered static and dynamic spontaneous brain activity. However, the conclusions regarding this are inconsistent. Evidence has revealed that this inconsistency could be due to mixed effects of ag…
View article: IGFBP1 facilitates tumor proliferation, invasion and migration by modulating the MAPK- ERK signaling pathway in lung adenocarcinoma
IGFBP1 facilitates tumor proliferation, invasion and migration by modulating the MAPK- ERK signaling pathway in lung adenocarcinoma Open
Objective Lung adenocarcinoma (LUAD) is the most prevalent histological subtype of lung cancer, and lymph node metastasis serves as a significant prognostic risk factor. The identification of molecular biomarkers associated with lymph node…
View article: Abnormal Granger causal connectivity based on altered gray matter volume and associated neurotransmitters of adolescents with internet gaming disorder revealed by a multimodal neuroimaging study
Abnormal Granger causal connectivity based on altered gray matter volume and associated neurotransmitters of adolescents with internet gaming disorder revealed by a multimodal neuroimaging study Open
Although prior studies have revealed alterations in gray matter volume (GMV) among individuals with internet gaming disorder (IGD). The brain's multifaceted functions hinge crucially on the intricate connections and communication among dis…
View article: Altered functional connectivity within the primary visual networks and neurotransmitter activity in male smokers: A group ICA study
Altered functional connectivity within the primary visual networks and neurotransmitter activity in male smokers: A group ICA study Open
Smoking puts patients at high risk for cognitive and psychiatric disorders. The aim of this study was to explore the effects of nicotine use on primary visual network (PVN) and its association with neurotransmitters. A total of 59 tobacco …
View article: Polymeric nanocarrier via metabolism regulation mediates immunogenic cell death with spatiotemporal orchestration for cancer immunotherapy
Polymeric nanocarrier via metabolism regulation mediates immunogenic cell death with spatiotemporal orchestration for cancer immunotherapy Open
View article: Altered local intrinsic neural activity and molecular architecture in internet use disorders
Altered local intrinsic neural activity and molecular architecture in internet use disorders Open
These results suggest that local functional impairments are shown in the audiovisual and inhibitory control circuits in IGDs. This may be associated with underlying neurotransmitter system alterations. Therefore, this study provides the po…
View article: A Triple‐Responsive Polymeric Prodrug Nanoplatform with Extracellular ROS Consumption and Intracellular H<sub>2</sub>O<sub>2</sub> Self‐Generation for Imaging‐Guided Tumor Chemo‐Ferroptosis‐Immunotherapy (Adv. Healthcare Mater. 16/2024)
A Triple‐Responsive Polymeric Prodrug Nanoplatform with Extracellular ROS Consumption and Intracellular H<sub>2</sub>O<sub>2</sub> Self‐Generation for Imaging‐Guided Tumor Chemo‐Ferroptosis‐Immunotherapy (Adv. Healthcare Mater. 16/2024) Open
View article: Leveraging existing 16S rRNA gene surveys to decipher microbial signatures and dysbiosis in cervical carcinogenesis
Leveraging existing 16S rRNA gene surveys to decipher microbial signatures and dysbiosis in cervical carcinogenesis Open
View article: Purine metabolism in lung adenocarcinoma: A single‐cell analysis revealing prognostic and immunotherapeutic insights
Purine metabolism in lung adenocarcinoma: A single‐cell analysis revealing prognostic and immunotherapeutic insights Open
Lung adenocarcinoma (LUAD) is a prevalent subtype of lung cancer, yet the contribution of purine metabolism (PM) to its pathogenesis remains poorly elucidated. PM, a critical component of intracellular nucleotide synthesis and energy metab…
View article: Integrated analysis highlights the significance role of <scp>ITGAL</scp> in lung adenocarcinoma
Integrated analysis highlights the significance role of <span>ITGAL</span> in lung adenocarcinoma Open
Integrin alpha L (ITGAL), a member of the integrin family, is associated with carcinogenesis and immune regulation. However, the biological functions of ITGAL in lung adenocarcinoma (LUAD) remain poorly understood. In this study, we utiliz…
View article: Evaluation of the diagnostic performance of colposcopy in the detection of cervical high-grade squamous intraepithelial lesions among women with transformation zone type 3
Evaluation of the diagnostic performance of colposcopy in the detection of cervical high-grade squamous intraepithelial lesions among women with transformation zone type 3 Open
Background Inaccurate colposcopy diagnosis may lead to inappropriate management and increase the incidence of cervical cancer. This study aimed to evaluate the diagnostic accuracy of colposcopy in the detection of histologic cervical intra…
View article: Characteristics of lymphocyte subsets and inflammatory factors in patients with COVID-19
Characteristics of lymphocyte subsets and inflammatory factors in patients with COVID-19 Open
View article: Study of miRNA and lymphocyte subsets as potential biomarkers for the diagnosis and prognosis of gastric cancer
Study of miRNA and lymphocyte subsets as potential biomarkers for the diagnosis and prognosis of gastric cancer Open
Objective The aim of this study was to identify the expression of miRNA and lymphocyte subsets in the blood of gastric cancer (GC) patients, elucidate their clinical significance in GC, and establish novel biomarkers for the early diagnosi…
View article: Ursolic acid inhibits the metastasis of colon cancer by downregulating ARL4C expression
Ursolic acid inhibits the metastasis of colon cancer by downregulating ARL4C expression Open
Ursolic acid (UA), a natural pentacyclic triterpenoid, is known to exhibit various biological activities and anticancer effects. However, the underlying anticancer mechanism is not fully understood to date. The present study aimed to inves…