Mengzhu Xue
YOU?
Author Swipe
View article: Integrating non-target analysis and machine learning: a framework for contaminant source identification
Integrating non-target analysis and machine learning: a framework for contaminant source identification Open
Machine learning-based non-target analysis (ML-based NTA) faces the critical challenge of linking complex chemical signals to contamination sources. This review proposes a systematic framework of ML-assisted NTA for contaminant source iden…
View article: SF3B1K700E-driven transcriptional alterations in hematopoietic progenitors underlie blood cancer pathophysiology
SF3B1K700E-driven transcriptional alterations in hematopoietic progenitors underlie blood cancer pathophysiology Open
View article: Inhibiting RhoA Activation via GDP-state Stabilization to Relieve Heart Failure
Inhibiting RhoA Activation via GDP-state Stabilization to Relieve Heart Failure Open
SUMMARY High rates of heart failure (HF) morbidity and mortality have made targeting myocardial remodeling—particularly hypertrophy and fibrosis—a key therapeutic focus. RhoA, which regulates cytoskeletal reorganization and cell migration,…
View article: Probiotic-Derived Extracellular Reactive Oxygen Species for Efficient Oxidative Removal of Extracellular Antibiotic Resistance Genes in Water
Probiotic-Derived Extracellular Reactive Oxygen Species for Efficient Oxidative Removal of Extracellular Antibiotic Resistance Genes in Water Open
View article: Structural insights into sphingosine 1-phosphate receptor 4 activation
Structural insights into sphingosine 1-phosphate receptor 4 activation Open
S1PR4 is one of five subtypes of sphingosine 1-phosphate receptors (S1PRs) that regulate immune cell functioning, with functional distinctions to other subtypes. S1PR1-targeted modulators caused serious cardiac and vascular adverse effects…
View article: Antiviral Drugs (Synthetic Small Molecule Inhibitors and Nature Drugs) Against EV71 in Enteroviruses: Advances and Perspectives
Antiviral Drugs (Synthetic Small Molecule Inhibitors and Nature Drugs) Against EV71 in Enteroviruses: Advances and Perspectives Open
Enterovirus 71 (EV71) is a major virus that causes hand-foot - mouth disease. In cases of infants and young children, EV71 infection has been associated with severe neurological disease and potentially fatal systemic complications. The spo…
View article: Supplementary Figures from Multi-Omics Profiling Reveals Distinct Microenvironment Characterization and Suggests Immune Escape Mechanisms of Triple-Negative Breast Cancer
Supplementary Figures from Multi-Omics Profiling Reveals Distinct Microenvironment Characterization and Suggests Immune Escape Mechanisms of Triple-Negative Breast Cancer Open
Supplementary Figure 1. Workflow of our research. Supplementary Figure 2. Estimation of the optimal clustering numbers of triple-negative breast cancer microenvironment phenotypes. Supplementary Figure 3. Validation of microenvironment phe…
View article: Data from Multi-Omics Profiling Reveals Distinct Microenvironment Characterization and Suggests Immune Escape Mechanisms of Triple-Negative Breast Cancer
Data from Multi-Omics Profiling Reveals Distinct Microenvironment Characterization and Suggests Immune Escape Mechanisms of Triple-Negative Breast Cancer Open
Purpose:The tumor microenvironment has a profound impact on prognosis and immunotherapy. However, the landscape of the triple-negative breast cancer (TNBC) microenvironment has not been fully understood.Experimental Design:Using the larges…
View article: Supplementary Data from PHF5A Epigenetically Inhibits Apoptosis to Promote Breast Cancer Progression
Supplementary Data from PHF5A Epigenetically Inhibits Apoptosis to Promote Breast Cancer Progression Open
Fig. S1. RNA-seq based RBP Library construction and CRISPR screen reveals RBP hits related to tumor growth and metastasis. Fig. S2. PHF5A is frequently up-regulated in breast cancer, associated with poor clinical outcome, and essential for…
View article: Supplementary Data from PHF5A Epigenetically Inhibits Apoptosis to Promote Breast Cancer Progression
Supplementary Data from PHF5A Epigenetically Inhibits Apoptosis to Promote Breast Cancer Progression Open
Fig. S1. RNA-seq based RBP Library construction and CRISPR screen reveals RBP hits related to tumor growth and metastasis. Fig. S2. PHF5A is frequently up-regulated in breast cancer, associated with poor clinical outcome, and essential for…
View article: Data from PHF5A Epigenetically Inhibits Apoptosis to Promote Breast Cancer Progression
Data from PHF5A Epigenetically Inhibits Apoptosis to Promote Breast Cancer Progression Open
Alternative splicing (AS) and its regulation play critical roles in cancer, yet the dysregulation of AS and its molecular bases in breast cancer development have not yet been elucidated. Using an in vivo CRISPR screen targeting RNA-…
View article: Supplementary Tables from Multi-Omics Profiling Reveals Distinct Microenvironment Characterization and Suggests Immune Escape Mechanisms of Triple-Negative Breast Cancer
Supplementary Tables from Multi-Omics Profiling Reveals Distinct Microenvironment Characterization and Suggests Immune Escape Mechanisms of Triple-Negative Breast Cancer Open
Supplementary Table 1. The compendium of microenvironment cell subtypes in triple-negative breast cancer. Supplementary Table 2. Correlation of estimated microenvironment cell numbers between our compendium and CIBERSORT or MCP-counter. Su…
View article: Data from Multi-Omics Profiling Reveals Distinct Microenvironment Characterization and Suggests Immune Escape Mechanisms of Triple-Negative Breast Cancer
Data from Multi-Omics Profiling Reveals Distinct Microenvironment Characterization and Suggests Immune Escape Mechanisms of Triple-Negative Breast Cancer Open
Purpose:The tumor microenvironment has a profound impact on prognosis and immunotherapy. However, the landscape of the triple-negative breast cancer (TNBC) microenvironment has not been fully understood.Experimental Design:Using the larges…
View article: Supplementary Methods from Multi-Omics Profiling Reveals Distinct Microenvironment Characterization and Suggests Immune Escape Mechanisms of Triple-Negative Breast Cancer
Supplementary Methods from Multi-Omics Profiling Reveals Distinct Microenvironment Characterization and Suggests Immune Escape Mechanisms of Triple-Negative Breast Cancer Open
Supplementary Methods
View article: Supplementary Tables from Multi-Omics Profiling Reveals Distinct Microenvironment Characterization and Suggests Immune Escape Mechanisms of Triple-Negative Breast Cancer
Supplementary Tables from Multi-Omics Profiling Reveals Distinct Microenvironment Characterization and Suggests Immune Escape Mechanisms of Triple-Negative Breast Cancer Open
Supplementary Table 1. The compendium of microenvironment cell subtypes in triple-negative breast cancer. Supplementary Table 2. Correlation of estimated microenvironment cell numbers between our compendium and CIBERSORT or MCP-counter. Su…
View article: Supplementary Methods from Multi-Omics Profiling Reveals Distinct Microenvironment Characterization and Suggests Immune Escape Mechanisms of Triple-Negative Breast Cancer
Supplementary Methods from Multi-Omics Profiling Reveals Distinct Microenvironment Characterization and Suggests Immune Escape Mechanisms of Triple-Negative Breast Cancer Open
Supplementary Methods
View article: Data from PHF5A Epigenetically Inhibits Apoptosis to Promote Breast Cancer Progression
Data from PHF5A Epigenetically Inhibits Apoptosis to Promote Breast Cancer Progression Open
Alternative splicing (AS) and its regulation play critical roles in cancer, yet the dysregulation of AS and its molecular bases in breast cancer development have not yet been elucidated. Using an in vivo CRISPR screen targeting RNA-…
View article: Supplementary Figures from Multi-Omics Profiling Reveals Distinct Microenvironment Characterization and Suggests Immune Escape Mechanisms of Triple-Negative Breast Cancer
Supplementary Figures from Multi-Omics Profiling Reveals Distinct Microenvironment Characterization and Suggests Immune Escape Mechanisms of Triple-Negative Breast Cancer Open
Supplementary Figure 1. Workflow of our research. Supplementary Figure 2. Estimation of the optimal clustering numbers of triple-negative breast cancer microenvironment phenotypes. Supplementary Figure 3. Validation of microenvironment phe…
View article: Correction to: Ponatinib efficiently kills imatinib-resistant chronic eosinophilic leukemia cells harboring gatekeeper mutant T674I FIP1L1-PDGFRα: roles of Mcl-1 and β-catenin
Correction to: Ponatinib efficiently kills imatinib-resistant chronic eosinophilic leukemia cells harboring gatekeeper mutant T674I FIP1L1-PDGFRα: roles of Mcl-1 and β-catenin Open
View article: Multi-omics characterization of WNT pathway reactivation to ameliorate BET inhibitor resistance in liver cancer cells
Multi-omics characterization of WNT pathway reactivation to ameliorate BET inhibitor resistance in liver cancer cells Open
The Bromodomain and Extra-terminal domain (BET) proteins are promising targets in treating cancers. Although BET inhibitors have been in clinical trials, they are limited by lacking of suitable biomarkers to indicate drug responses in diff…
View article: Characterization of the genomic landscape and actionable mutations in Chinese breast cancers by clinical sequencing
Characterization of the genomic landscape and actionable mutations in Chinese breast cancers by clinical sequencing Open
View article: Truncated HDAC9 identified by integrated genome-wide screen as the key modulator for paclitaxel resistance in triple-negative breast cancer
Truncated HDAC9 identified by integrated genome-wide screen as the key modulator for paclitaxel resistance in triple-negative breast cancer Open
Rationale: Paclitaxel resistance is a major concern when treating triple-negative breast cancer (TNBC) patients. We aimed to identify candidates causing paclitaxel resistance and explore their significance in TNBC therapeutics. M…
View article: Dissecting the heterogeneity of the alternative polyadenylation profiles in triple-negative breast cancers
Dissecting the heterogeneity of the alternative polyadenylation profiles in triple-negative breast cancers Open
Background: Triple-negative breast cancer (TNBC) is an aggressive malignancy with high heterogeneity. However, the alternative polyadenylation (APA) profiles of TNBC remain unknown. Here, we aimed to define the characteristics of th…
View article: Author Correction: Competitive endogenous RNA is an intrinsic component of EMT regulatory circuits and modulates EMT
Author Correction: Competitive endogenous RNA is an intrinsic component of EMT regulatory circuits and modulates EMT Open
View article: Competitive endogenous RNA is an intrinsic component of EMT regulatory circuits and modulates EMT
Competitive endogenous RNA is an intrinsic component of EMT regulatory circuits and modulates EMT Open
View article: Multi-Omics Profiling Reveals Distinct Microenvironment Characterization and Suggests Immune Escape Mechanisms of Triple-Negative Breast Cancer
Multi-Omics Profiling Reveals Distinct Microenvironment Characterization and Suggests Immune Escape Mechanisms of Triple-Negative Breast Cancer Open
Purpose: The tumor microenvironment has a profound impact on prognosis and immunotherapy. However, the landscape of the triple-negative breast cancer (TNBC) microenvironment has not been fully understood. Experimental Design: Using the lar…
View article: Genomic and Transcriptomic Landscape of Triple-Negative Breast Cancers: Subtypes and Treatment Strategies
Genomic and Transcriptomic Landscape of Triple-Negative Breast Cancers: Subtypes and Treatment Strategies Open
View article: CircRNAFisher: a systematic computational approach for de novo circular RNA identification
CircRNAFisher: a systematic computational approach for de novo circular RNA identification Open
View article: Computational identification of mutually exclusive transcriptional drivers dysregulating metastatic microRNAs in prostate cancer
Computational identification of mutually exclusive transcriptional drivers dysregulating metastatic microRNAs in prostate cancer Open
Androgen-ablation therapies, which are the standard treatment for metastatic prostate cancer, invariably lead to acquired resistance. Hence, a systematic identification of additional drivers may provide useful insights into the development…
View article: Synergistic action of master transcription factors controls epithelial-to-mesenchymal transition
Synergistic action of master transcription factors controls epithelial-to-mesenchymal transition Open
Epithelial-to-mesenchymal transition (EMT) is a complex multistep process in which phenotype switches are mediated by a network of transcription factors (TFs). Systematic characterization of all dynamic TFs controlling EMT state transition…