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View article: Fiber-like Action of d-Fagomine on the Gut Microbiota and Body Weight of Healthy Rats
Fiber-like Action of d-Fagomine on the Gut Microbiota and Body Weight of Healthy Rats Open
The goal of this work is to explore if the changes induced by d-fagomine in the gut microbiota are compatible with its effect on body weight and inflammation markers in rats. Methods: Sprague Dawley rats were fed a standard diet supplement…
View article: Effects of a Fish Oil Rich in Docosahexaenoic Acid on Cardiometabolic Risk Factors and Oxidative Stress in Healthy Rats
Effects of a Fish Oil Rich in Docosahexaenoic Acid on Cardiometabolic Risk Factors and Oxidative Stress in Healthy Rats Open
Omega-3 polyunsaturated fatty acids are associated with a lower risk of cardiometabolic diseases. However, docosahexaenoic acid (DHA) is easily oxidized, leading to cellular damage. The present study examined the effects of an increased co…
View article: Inter‐Individual Variability in Insulin Response after Grape Pomace Supplementation in Subjects at High Cardiometabolic Risk: Role of Microbiota and miRNA
Inter‐Individual Variability in Insulin Response after Grape Pomace Supplementation in Subjects at High Cardiometabolic Risk: Role of Microbiota and miRNA Open
Scope Dietary polyphenols have shown promising effects in mechanistic and preclinical studies on the regulation of cardiometabolic alterations. Nevertheless, clinical trials have provided contradictory results, with high inter‐individual v…
View article: Implication of gut microbiota in the physiology of rats intermittently exposed to cold and hypobaric hypoxia
Implication of gut microbiota in the physiology of rats intermittently exposed to cold and hypobaric hypoxia Open
This study examines the influence of intermittent exposure to cold, hypobaric hypoxia, and their combination, in gut microbiota and their metabolites in vivo, and explores their effects on the physiology of the host. Sprague-Dawley rats we…
View article: Modifications of Gut Microbiota after Grape Pomace Supplementation in Subjects at Cardiometabolic Risk: A Randomized Cross-Over Controlled Clinical Trial
Modifications of Gut Microbiota after Grape Pomace Supplementation in Subjects at Cardiometabolic Risk: A Randomized Cross-Over Controlled Clinical Trial Open
Polyphenols are dietary bioactive compounds able to induce modifications in the gut microbiota profile, although more clinical studies are needed. With this aim, a randomized cross-over clinical trial was conducted, where 49 subjects at ca…
View article: The buckwheat iminosugar D-fagomine attenuates sucrose-induced steatosis and hypertension in rats
The buckwheat iminosugar D-fagomine attenuates sucrose-induced steatosis and hypertension in rats Open
D-Fagomine (1,2 dideoxynojirimycin) is an iminosugar, a carbohydrate analogue that includes an endocyclic nitrogen instead of oxygen, that is naturally present in buckwheat and buckwheat-based foodstuffs. This study examines the long-term …
View article: Effects of combined d-fagomine and omega-3 PUFAs on gut microbiota subpopulations and diabetes risk factors in rats fed a high-fat diet
Effects of combined d-fagomine and omega-3 PUFAs on gut microbiota subpopulations and diabetes risk factors in rats fed a high-fat diet Open
Food contains bioactive compounds that may prevent changes in gut microbiota associated with Westernized diets. The aim of this study is to explore the possible additive effects of d -fagomine and ω-3 PUFAs (EPA/DHA 1:1) on gut microbiota …
View article: Combined Buckwheat d-Fagomine and Fish Omega-3 PUFAs Stabilize the Populations of Gut Prevotella and Bacteroides While Reducing Weight Gain in Rats
Combined Buckwheat d-Fagomine and Fish Omega-3 PUFAs Stabilize the Populations of Gut Prevotella and Bacteroides While Reducing Weight Gain in Rats Open
Some functional food components may help maintain homeostasis by promoting balanced gut microbiota. Here, we explore the possible complementary effects of d-fagomine and ω-3 polyunsaturated fatty acids (ω-3 PUFAs) eicosapentaenoic acid/doc…
View article: The Buckwheat Iminosugar <scp>d</scp>‐Fagomine Attenuates Sucrose‐Induced Steatosis and Hypertension in Rats
The Buckwheat Iminosugar <span>d</span>‐Fagomine Attenuates Sucrose‐Induced Steatosis and Hypertension in Rats Open
Scope This study examines the long‐term functional effects of d ‐fagomine on sucrose‐induced factors of metabolic dysfunctions and explores possible molecular mechanisms behind its action. Methods and results Wistar Kyoto rats are fed a 35…
View article: The influence of combined buckwheat D-fagomine and fish omega-3 PUFAs on beneficial gut bacteria in rats
The influence of combined buckwheat D-fagomine and fish omega-3 PUFAs on beneficial gut bacteria in rats Open
Poster.-- 13th European Nutrition Conference - Malnutrition in an Obese World: European Perspectives, Dublin, 15-18 October 2019
View article: Front cover: Functional Effects of the Buckwheat Iminosugar <scp>d</scp>‐Fagomine on Rats with Diet‐Induced Prediabetes
Front cover: Functional Effects of the Buckwheat Iminosugar <span>d</span>‐Fagomine on Rats with Diet‐Induced Prediabetes Open
Mol. Nutr. Food Res. 2018, 62, 1800373 DOI: 10.1002/mnfr.201800373 d-Fagomine, an iminosugar found in buckwheat, counteracts the weight gain and elevated blood glucose levels induced by an excessive intake of fat. In article number 1800373…
View article: Functional Effects of the Buckwheat Iminosugar <scp>d</scp>‐Fagomine on Rats with Diet‐Induced Prediabetes
Functional Effects of the Buckwheat Iminosugar <span>d</span>‐Fagomine on Rats with Diet‐Induced Prediabetes Open
Scope The goals of this work are to test if d ‐fagomine, an iminosugar that reduces body weight gain, can delay the appearance of a fat‐induced prediabetic state in a rat model and to explore possible mechanisms behind its functional actio…
View article: Mechanistically different effects of fat and sugar on insulin resistance, hypertension, and gut microbiota in rats
Mechanistically different effects of fat and sugar on insulin resistance, hypertension, and gut microbiota in rats Open
Insulin resistance (IR) and impaired glucose tolerance (IGT) are the first manifestations of diet-induced metabolic alterations leading to Type 2 diabetes, while hypertension is the deadliest risk factor of cardiovascular disease. The role…