Mercedes Delgado-Valverde
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View article: Visceral adipose tissue and liver fat on 17-beta estradiol-dominant gender-affirming hormone therapy: A US-based cohort
Visceral adipose tissue and liver fat on 17-beta estradiol-dominant gender-affirming hormone therapy: A US-based cohort Open
Context Data on the metabolic effects of contemporaneous gender-affirming hormone therapy (GAHT) are limited. Objective To characterize the metabolic effects of GAHT, i.e. estradiol with anti-androgen therapy. Design Prospective observatio…
View article: Characterization of a <i>bla</i> <sub>KPC-3</sub> -carrying plasmid in a clinical isolate of <i>Klebsiella pneumoniae</i> belonging to the emerging successful clone ST147
Characterization of a <i>bla</i> <sub>KPC-3</sub> -carrying plasmid in a clinical isolate of <i>Klebsiella pneumoniae</i> belonging to the emerging successful clone ST147 Open
Klebsiella pneumoniae ST147 has emerged as a successful clone able to efficiently disseminate a number of carbapenemases, including bla KPC . This study compared a representative bla KPC-3 -carrying plasmid of an ST147 clone with plasmids …
View article: Finiteness and the Emergence of Dualities
Finiteness and the Emergence of Dualities Open
We argue that the finiteness of quantum gravity amplitudes in fully compactified theories (at least in supersymmetric cases) leads to a bottom-up prediction for the existence of non-trivial dualities. In particular, finiteness requires the…
View article: [Translated article] Physicochemical and microbiological stability study of two new preservative-free methylprednisolone eye drops
[Translated article] Physicochemical and microbiological stability study of two new preservative-free methylprednisolone eye drops Open
1 mg/mL MTPSS eye drops show physicochemical and microbiological stability for 21 days under refrigeration, compared to 42 days for 10 mg/mL eye drops stored under the same conditions. However, since they do not include preservatives in th…
View article: Corrigendum: CARB-ES-19 multicenter study of carbapenemase-producing Klebsiella pneumoniae and Escherichia coli from all Spanish provinces reveals interregional spread of high-risk clones such as ST307/OXA-48 and ST512/KPC-3
Corrigendum: CARB-ES-19 multicenter study of carbapenemase-producing Klebsiella pneumoniae and Escherichia coli from all Spanish provinces reveals interregional spread of high-risk clones such as ST307/OXA-48 and ST512/KPC-3 Open
[This corrects the article DOI: 10.3389/fmicb.2022.918362.].
View article: <i>In Vitro</i> Activity of Cefiderocol Compared to Other Antimicrobials against a Collection of Metallo-Beta-Lactamase-Producing Gram-Negative Bacilli from Southern Spain
<i>In Vitro</i> Activity of Cefiderocol Compared to Other Antimicrobials against a Collection of Metallo-Beta-Lactamase-Producing Gram-Negative Bacilli from Southern Spain Open
This article demonstrates the efficacy of cefiderocol against a large collection of well-characterized metallo-beta-lactamase-producing isolates, some of them even producing double carbapenemases. Furthermore, cefiderocol activity is compa…
View article: Imipenem-Relebactam Susceptibility in <i>Enterobacterales</i> Isolates Recovered from ICU Patients from Spain and Portugal (SUPERIOR and STEP Studies)
Imipenem-Relebactam Susceptibility in <i>Enterobacterales</i> Isolates Recovered from ICU Patients from Spain and Portugal (SUPERIOR and STEP Studies) Open
We comparatively evaluate the in vitro activity of a drug combination consisting of a carbapenem (imipenem) and a novel inhibitor of beta-lactamases (relebactam), a mechanism that destroys beta-lactam antibiotics. We assess the activity ag…
View article: Infections in patients colonized with carbapenem-resistant Gram-negative bacteria in a medium Spanish city
Infections in patients colonized with carbapenem-resistant Gram-negative bacteria in a medium Spanish city Open
Objective. Because there are few studies on the clinical implications of colonization by carbapenem-resistant gram-negative bacteria (CRB) this was analyzed in rectal smears (RS) and pharyngeals (PS) and its ability to predict infection/co…
View article: Impact of COVID-19 on Families of Pediatric Solid Organ Transplant Recipients
Impact of COVID-19 on Families of Pediatric Solid Organ Transplant Recipients Open
Objective The COVID-19 pandemic and lockdown measures have had a clear psychological impact on families, and specifically those with children with chronic illnesses have reported greater overloads and exhaustion. The objective of this stud…
View article: End of Life Intervention Program During COVID-19 in Vall d'Hebron University Hospital
End of Life Intervention Program During COVID-19 in Vall d'Hebron University Hospital Open
Introduction: The coronavirus disease 19 (COVID-19) and its consequences have placed our societies and healthcare systems under pressure. Also, a major impact on the individual and societal experience of death, dying, and bereavement has b…
View article: Population Pharmacokinetics of Piperacillin in Non-Critically Ill Patients with Bacteremia Caused by Enterobacteriaceae
Population Pharmacokinetics of Piperacillin in Non-Critically Ill Patients with Bacteremia Caused by Enterobacteriaceae Open
This study analyzes the pharmacokinetic variability of piperacillin in non-critically ill patients with Enterobacteriaceae bloodstream infections (EBSI) and explores predicted clinical outcomes and piperacillin-related neurotoxicity under …
View article: Household acquisition and transmission of extended-spectrum β-lactamase (ESBL) -producing Enterobacteriaceae after hospital discharge of ESBL-positive index patients
Household acquisition and transmission of extended-spectrum β-lactamase (ESBL) -producing Enterobacteriaceae after hospital discharge of ESBL-positive index patients Open
German Clinical Trials Register, DRKS-ID: DRKS00013250.
View article: Formulation, long-term physicochemical and microbiological stability of 15% topical resorcinol for hidradenitis suppurativa
Formulation, long-term physicochemical and microbiological stability of 15% topical resorcinol for hidradenitis suppurativa Open
Only the formulation package in aluminium tubes showed physicochemical and microbiological stability of resorcinol for 12 months at room temperature (25°C±2°C).
View article: Distinct epidemiology and resistance mechanisms affecting ceftolozane/tazobactam in<i>Pseudomonas aeruginosa</i>isolates recovered from ICU patients in Spain and Portugal depicted by WGS
Distinct epidemiology and resistance mechanisms affecting ceftolozane/tazobactam in<i>Pseudomonas aeruginosa</i>isolates recovered from ICU patients in Spain and Portugal depicted by WGS Open
Objectives To analyse the epidemiology, the resistome and the virulome of ceftolozane/tazobactam-susceptible or -resistant Pseudomonas aeruginosa clinical isolates recovered from surveillance studies in Portugal (STEP, 2017–18) and Spain (…
View article: WGS characterization of MDR Enterobacterales with different ceftolozane/tazobactam susceptibility profiles during the SUPERIOR surveillance study in Spain
WGS characterization of MDR Enterobacterales with different ceftolozane/tazobactam susceptibility profiles during the SUPERIOR surveillance study in Spain Open
Objectives To analyse by WGS the ceftolozane/tazobactam (C/T) resistance mechanisms in Escherichia coli and Klebsiella spp. isolates recovered from complicated intra-abdominal and urinary tract infections in patients from Spanish ICUs (SUP…
View article: Mechanisms of Tolerance and Resistance to Chlorhexidine in Clinical Strains of Klebsiella pneumoniae Producers of Carbapenemase: Role of New Type II Toxin-Antitoxin System, PemIK
Mechanisms of Tolerance and Resistance to Chlorhexidine in Clinical Strains of Klebsiella pneumoniae Producers of Carbapenemase: Role of New Type II Toxin-Antitoxin System, PemIK Open
Although the failure of antibiotic treatment is normally attributed to resistance, tolerance and persistence display a significant role in the lack of response to antibiotics. Due to the fact that several nosocomial pathogens show a high l…
View article: Carbapenemase-Producing Gram-Negative Bacteria in Andalusia, Spain, 2014–2018
Carbapenemase-Producing Gram-Negative Bacteria in Andalusia, Spain, 2014–2018 Open
The emergence and spread of carbapenemase-producing gram-negative bacteria is a major public health concern. We used data collected from microbiology laboratories as part of the PIRASOA program during 2014-2018 to study the epidemiology of…
View article: Whole Transcriptomic Analysis of Mechanisms of Tolerance and Resistance to Chlorhexidine in Clinical Strains of Klebsiella Pneumoniae Producers of Carbapenemase
Whole Transcriptomic Analysis of Mechanisms of Tolerance and Resistance to Chlorhexidine in Clinical Strains of Klebsiella Pneumoniae Producers of Carbapenemase Open
Although the failure of antibiotic treatment is normally attributed to resistance, tolerance and persistence display a significant role in the lack of response to antibiotics. Due to the fact that several nosocomial pathogens show a high l…
View article: Sleep in adults with autism spectrum disorder and attention deficit/hyperactivity disorder: A systematic review and meta-analysis
Sleep in adults with autism spectrum disorder and attention deficit/hyperactivity disorder: A systematic review and meta-analysis Open
Sleep-related problems have been frequently reported in neurodevelopmental disorders, with special emphasis in Autism Spectrum Disorder (ASD) and Attention Deficit/Hyperactivity Disorder (ADHD). The aim of the present study is to conduct a…
View article: Activity of cefiderocol against high-risk clones of multidrug-resistant Enterobacterales, Acinetobacter baumannii, Pseudomonas aeruginosa and Stenotrophomonas maltophilia
Activity of cefiderocol against high-risk clones of multidrug-resistant Enterobacterales, Acinetobacter baumannii, Pseudomonas aeruginosa and Stenotrophomonas maltophilia Open
Background Cefiderocol is a novel siderophore cephalosporin, developed for activity against MDR Gram-negative bacilli (MDR-GNB). Objectives To assess the in vitro antibacterial activity of cefiderocol against a collection of MDR-GNB clinic…
View article: 3PC-002 Microbiological stability test of 15% topical resorcinol for quality control
3PC-002 Microbiological stability test of 15% topical resorcinol for quality control Open
Background and importance Hidradenitis suppurativa (HS) is an inflammatory skin disease that causes painful boils and abscess formation, especially localised in intertriginous areas. Resorcinol is a phenol derivate, and in topical self-tre…
View article: Impact of De-escalation on Prognosis of Patients With Bacteremia due to Enterobacteriaceae: A Post Hoc Analysis From a Multicenter Prospective Cohort
Impact of De-escalation on Prognosis of Patients With Bacteremia due to Enterobacteriaceae: A Post Hoc Analysis From a Multicenter Prospective Cohort Open
Background More data are needed about the safety of antibiotic de-escalation in specific clinical situations as a strategy to reduce exposure to broad-spectrum antibiotics. The aims of this study were to investigate predictors of de-escala…