Mercedes Martínez
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View article: Impact of Digital Nutrition Education in Enhancing Diet Quality Among Older Adults in Congregate Meal Program
Impact of Digital Nutrition Education in Enhancing Diet Quality Among Older Adults in Congregate Meal Program Open
View article: Posttransplant rituximab exposure and risk of PTLD in solid organ transplant recipients with EBV DNAemia
Posttransplant rituximab exposure and risk of PTLD in solid organ transplant recipients with EBV DNAemia Open
The association between Epstein-Barr virus (EBV) DNAemia after solid organ transplantation (SOT) and posttransplant lymphoproliferative disorder (PTLD) is well described. Published data support preemptive rituximab for EBV DNAemia after bo…
View article: Novel treatment of Yttrium-90 radioembolization-induced liver disease (REILD) with defibrotide in a pediatric liver transplant recipient
Novel treatment of Yttrium-90 radioembolization-induced liver disease (REILD) with defibrotide in a pediatric liver transplant recipient Open
View article: Risk scores for choledocholithiasis perform poorly in patients with hemolytic diseases: a PEDI database report
Risk scores for choledocholithiasis perform poorly in patients with hemolytic diseases: a PEDI database report Open
Patients with hemolytic diseases are at increased risk for gallstone-related complications. Modified scoring systems have been developed to assess which pediatric patients would benefit from endoscopic retrograde cholangiopancreatography (…
View article: Recipient γδ T cells contribute to graft rejection after human intestinal transplantation
Recipient γδ T cells contribute to graft rejection after human intestinal transplantation Open
View article: Trending Microbiome Dysbiosis Over Time as an Early Assessment of Intestinal Transplant Rejection Risk
Trending Microbiome Dysbiosis Over Time as an Early Assessment of Intestinal Transplant Rejection Risk Open
View article: Three-way T-cell chimerism and alloreactivity using single cell profiling in a patient receiving a second intestinal transplant
Three-way T-cell chimerism and alloreactivity using single cell profiling in a patient receiving a second intestinal transplant Open
View article: Reconsidering the immune pathway of intestinal transplant rejection: Novel insights from comparison with Crohn’s disease
Reconsidering the immune pathway of intestinal transplant rejection: Novel insights from comparison with Crohn’s disease Open
View article: Impact of pre-transplant immune checkpoint inhibitor use on post-transplant outcomes in HCC: A systematic review and individual patient data meta-analysis
Impact of pre-transplant immune checkpoint inhibitor use on post-transplant outcomes in HCC: A systematic review and individual patient data meta-analysis Open
View article: Dynamic establishment and maintenance of the human intestinal B cell population and repertoire following transplantation in a pediatric-dominated cohort
Dynamic establishment and maintenance of the human intestinal B cell population and repertoire following transplantation in a pediatric-dominated cohort Open
Introduction It is unknown how intestinal B cell populations and B cell receptor (BCR) repertoires are established and maintained over time in humans. Following intestinal transplantation (ITx), surveillance ileal mucosal biopsies provide …
View article: Development of a large animal orthotopic intestinal transplantation model with long-term survival for study of immunologic outcomes
Development of a large animal orthotopic intestinal transplantation model with long-term survival for study of immunologic outcomes Open
Introduction Intestinal transplantation (ITx) is the last remaining therapy for patients with intestinal failure once parenteral nutrition is no longer an option, however its use is limited by immunological complications, including high ra…
View article: Cell immunity to SARS-CoV-2 after natural infection and/or different vaccination regimens
Cell immunity to SARS-CoV-2 after natural infection and/or different vaccination regimens Open
Background The aim of the study was to evaluate the humoral and cellular immunity after SARS-CoV-2 infection and/or vaccination according to the type of vaccine, number of doses and combination of vaccines. Methods Volunteer subjects were …
View article: Dynamic establishment of recipient resident memory T cell repertoire after human intestinal transplantation
Dynamic establishment of recipient resident memory T cell repertoire after human intestinal transplantation Open
View article: Plasticity of intragraft alloreactive T cell clones in human gut correlates with transplant outcomes
Plasticity of intragraft alloreactive T cell clones in human gut correlates with transplant outcomes Open
The site of transition between tissue-resident memory (TRM) and circulating phenotypes of T cells is unknown. We integrated clonotype, alloreactivity, and gene expression profiles of graft-repopulating recipient T cells in the intestinal m…
View article: The diagnostic yield of exome sequencing in liver diseases from a curated gene panel
The diagnostic yield of exome sequencing in liver diseases from a curated gene panel Open
View article: Dynamic establishment and maintenance of the human intestinal B cell population and repertoire following transplantation
Dynamic establishment and maintenance of the human intestinal B cell population and repertoire following transplantation Open
It is unknown how intestinal B cell populations and B cell receptor (BCR) repertoires are established and maintained over time in humans. Following intestinal transplantation (ITx), surveillance ileal mucosal biopsies provide a unique oppo…
View article: Vascular thrombosis after pediatric liver transplantation: Is prevention achievable?
Vascular thrombosis after pediatric liver transplantation: Is prevention achievable? Open
Prophylactic anticoagulation did not increase bleeding complications in this cohort. The only independent factor associated with VT was open fascia, likely a graft/recipient size mismatch surrogate, supporting the need to improve surgical …
View article: Differences in the inflammatory response among hospitalized patients with distinct variants of SARS-CoV-2
Differences in the inflammatory response among hospitalized patients with distinct variants of SARS-CoV-2 Open
The SARS-CoV-2 variants demonstrate diverse transmission patterns, modifications in infectivity, and immune response. Changes in disease manifestation may be attributed to vaccination and the virus’s reduced capacity to induce inflammation…
View article: Pediatric ERCP in the Setting of Acute Pancreatitis
Pediatric ERCP in the Setting of Acute Pancreatitis Open
Previous studies have demonstrated the safety of performing endoscopic retrograde cholangiopancreatography (ERCP) in the pediatric population; however, few have addressed the outcomes of children undergoing ERCP during acute pancreatitis (…
View article: HERV1-env Induces Unfolded Protein Response Activation in Autoimmune Liver Disease: A Potential Mechanism for Regulatory T Cell Dysfunction
HERV1-env Induces Unfolded Protein Response Activation in Autoimmune Liver Disease: A Potential Mechanism for Regulatory T Cell Dysfunction Open
Regulatory T cells (Tregs) are not terminally differentiated but can acquire effector properties. Here we report an increased expression of human endogenous retrovirus 1 (HERV1-env) proteins in Tregs of patients with de novo autoimmune hep…
View article: Low-Dose TMP-SMX for Pneumocystis jirovecii Pneumonia Prophylaxis in Pediatric Solid Organ Transplant Recipients
Low-Dose TMP-SMX for Pneumocystis jirovecii Pneumonia Prophylaxis in Pediatric Solid Organ Transplant Recipients Open
OBJECTIVE Pneumocystis jirovecii pneumonia (PJP) is an opportunistic infection that adversely affects solid organ transplant (SOT) recipients. Published guidelines endorse 5 to 10 mg/kg/day (trimethoprim component) trimethoprim-sulfamethox…
View article: Analysis of Adverse Effects of COVID-19 Vaccines in Spain following Booster Dose
Analysis of Adverse Effects of COVID-19 Vaccines in Spain following Booster Dose Open
The present study evaluates the adverse effects of three vaccines: AstraZeneca (Vaxzevria), Pfizer/BioNTech (Comirnaty) and Moderna (Spikevax) according to the dose. From 733 participants collected, the vaccine schedule was as follows: 330…
View article: Challenges associated with diagnostic exome sequencing in liver diseases
Challenges associated with diagnostic exome sequencing in liver diseases Open
Exome sequencing (ES) has been used in a variety of clinical settings but there are limited data on its utility for diagnosis and/or prediction of monogenic liver diseases. We analyzed ES data in 758 patients with liver diseases., We devel…
View article: Stable liver graft post anti‐PD1 therapy as a bridge to transplantation in an adolescent with hepatocellular carcinoma
Stable liver graft post anti‐PD1 therapy as a bridge to transplantation in an adolescent with hepatocellular carcinoma Open
Background Immunotherapy, specifically immune checkpoint inhibitors (ICIs), including anti‐programmed cell death 1 (anti‐PD1), has recently received clinical approval for the treatment of adult hepatocellular carcinoma (HCC). However, the …
View article: Risk scores to predict mortality 2 and 5 years after surgery for colorectal cancer in elderly patients
Risk scores to predict mortality 2 and 5 years after surgery for colorectal cancer in elderly patients Open
View article: Acute Liver Injury Among Pediatric Liver Transplantation Recipients With Coronavirus Disease 2019
Acute Liver Injury Among Pediatric Liver Transplantation Recipients With Coronavirus Disease 2019 Open
Coronavirus disease 2019 (COVID‐19) is an ongoing pandemic. The occurrence of acute liver injury (ALI) has been reported in liver transplant (LT) recipients; however, the findings on children remain controversial. This is the first extensi…
View article: Recurrence of Primary Sclerosing Cholangitis After Liver Transplant in Children: An International Observational Study
Recurrence of Primary Sclerosing Cholangitis After Liver Transplant in Children: An International Observational Study Open
Background and Aims Recurrent primary sclerosing cholangitis (rPSC) following liver transplant (LT) has a negative impact on graft and patient survival; little is known about risk factors for rPSC or disease course in children. Approach an…
View article: Liver involvement in children with SARS‐COV‐2 infection: Two distinct clinical phenotypes caused by the same virus
Liver involvement in children with SARS‐COV‐2 infection: Two distinct clinical phenotypes caused by the same virus Open
Background and Aims Severe Acute Respiratory Syndrome Coronavirus‐2 (SARS‐CoV‐2) associated acute liver injury (ALI) has been linked to poor outcomes in adults. Here we compare characteristics in children with elevated ALT (E‐ALT) in two d…
View article: Lymphohematopoietic graft-versus-host responses promote mixed chimerism in patients receiving intestinal transplantation
Lymphohematopoietic graft-versus-host responses promote mixed chimerism in patients receiving intestinal transplantation Open
In humans receiving intestinal transplantation (ITx), long-term multilineage blood chimerism often develops. Donor T cell macrochimerism (≥4%) frequently occurs without graft-versus-host disease (GVHD) and is associated with reduced reject…
View article: Severe Acute Respiratory Syndrome Coronavirus‐2 Infection in Children With Liver Transplant and Native Liver Disease
Severe Acute Respiratory Syndrome Coronavirus‐2 Infection in Children With Liver Transplant and Native Liver Disease Open
Objective: Increased mortality risk because of severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV2) infection in adults with native liver disease (LD) and liver transplant (LT) is associated with advanced age and comorbid conditions…