Meredith Corley
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View article: Evaluation of novel computational methods to identify RNA-binding protein footprints from structural data
Evaluation of novel computational methods to identify RNA-binding protein footprints from structural data Open
RNA-binding proteins (RBP) play diverse roles in mRNA processing and function. However, from thousands of RBPs encoded in the human genome, a detailed molecular understanding of their interactions with RNA is available only for a small fra…
View article: Selecting against accidental RNA interactions
Selecting against accidental RNA interactions Open
Random base-pairing interactions between messenger RNAs and noncoding RNAs can reduce translation efficiency.
View article: ATOM-1: A Foundation Model for RNA Structure and Function Built on Chemical Mapping Data
ATOM-1: A Foundation Model for RNA Structure and Function Built on Chemical Mapping Data Open
RNA-based medicines and RNA-targeting drugs are emerging as promising new approaches for treating disease. Optimizing these therapeutics by naive experimental screening is a time-consuming and expensive process, while rational design requi…
View article: fSHAPE, fSHAPE-eCLIP, and SHAPE-eCLIP probe transcript regions that interact with specific proteins
fSHAPE, fSHAPE-eCLIP, and SHAPE-eCLIP probe transcript regions that interact with specific proteins Open
Selective 2'-hydroxyl acylation analyzed by primer extension (SHAPE) structure probing techniques characterize the secondary structure of RNA molecules, which influence their functions and interactions. A variation of SHAPE, footprinting S…
View article: Detecting riboSNitches with RNA folding algorithms: a genome-wide benchmark
Detecting riboSNitches with RNA folding algorithms: a genome-wide benchmark Open
Ribonucleic acid (RNA) secondary structure prediction continues to be a significant challenge, in particular when attempting to model sequences with less rigidly defined structures, such as messenger and non-coding RNAs. Crucial to interpr…
View article: An RNA structure-mediated, posttranscriptional model of human α-1-antitrypsin expression
An RNA structure-mediated, posttranscriptional model of human α-1-antitrypsin expression Open
Protein and mRNA expression are in most cases poorly correlated, which suggests that the posttranscriptional regulatory program of a cell is an important component of gene expression. This regulatory network is still poorly understood, inc…
View article: The functional effects of RNA structure: from riboSNitches to translational control
The functional effects of RNA structure: from riboSNitches to translational control Open
Ribonucleic Acid (RNA) is a nucleotide polymer that, like Deoxyribonuclic acid (DNA), has an essential role in in the cell. RNA molecules are structurally distinct from DNA in the diversity of structures they adopt, due to stable intramole…
View article: Messenger RNA Structure Regulates Translation Initiation: A Mechanism Exploited from Bacteria to Humans
Messenger RNA Structure Regulates Translation Initiation: A Mechanism Exploited from Bacteria to Humans Open
ADVERTISEMENT RETURN TO ISSUEViewpointNEXTMessenger RNA Structure Regulates Translation Initiation: A Mechanism Exploited from Bacteria to HumansAnthony M. Mustoe*Anthony M. MustoeDepartment of Chemistry, University of North Carolina at Ch…
View article: An RNA structure-mediated, posttranscriptional model of human α-1-antitrypsin expression
An RNA structure-mediated, posttranscriptional model of human α-1-antitrypsin expression Open
Significance Protein and mRNA expression are in most cases poorly correlated, which suggests that the posttranscriptional regulatory program of a cell is an important component of gene expression. This regulatory network is still poorly un…
View article: Selecting against accidental RNA interactions
Selecting against accidental RNA interactions Open
Random base-pairing interactions between messenger RNAs and noncoding RNAs can reduce translation efficiency.