Meredith Mahnke
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View article: Similar destabilization of neural dynamics under different general anesthetics
Similar destabilization of neural dynamics under different general anesthetics Open
Different classes of anesthetics can induce unconsciousness despite acting through distinct biological mechanisms. This raises the possibility that they produce a convergent effect on the dynamics or temporal evolution of neural population…
View article: Convergent effects of different anesthetics on changes in phase alignment of cortical oscillations
Convergent effects of different anesthetics on changes in phase alignment of cortical oscillations Open
Many anesthetics cause loss of consciousness despite having diverse underlying molecular and circuit actions. To explore the convergent effects of these drugs, we examine how anesthetic doses of ketamine and dexmedetomidine affect bilatera…
View article: Evidence for an active handoff between cerebral hemispheres during target tracking
Evidence for an active handoff between cerebral hemispheres during target tracking Open
The brain has somewhat separate cognitive resources for the left and right sides of our visual field. Despite this lateralization, we have a smooth and unified perception of our environment. This raises the question of how the cerebral hem…
View article: Propofol-mediated loss of consciousness disrupts predictive routing and local field phase modulation of neural activity
Propofol-mediated loss of consciousness disrupts predictive routing and local field phase modulation of neural activity Open
Predictive coding is a fundamental function of the cortex. The predictive routing model proposes a neurophysiological implementation for predictive coding. Predictions are fed back from the deep-layer cortex via alpha/beta (8 to 30 Hz) osc…
View article: Propofol anesthesia destabilizes neural dynamics across cortex
Propofol anesthesia destabilizes neural dynamics across cortex Open
Every day, hundreds of thousands of people undergo general anesthesia. One hypothesis is that anesthesia disrupts dynamic stability-the ability of the brain to balance excitability with the need to be stable and controllable. To test this …
View article: Convergent effects of different anesthetics on changes in phase alignment of cortical oscillations
Convergent effects of different anesthetics on changes in phase alignment of cortical oscillations Open
Many anesthetics cause loss of responsiveness despite having diverse underlying molecular and circuit actions. To explore the convergent effects of these drugs, we examined how anesthetic doses of ketamine and dexmedetomidine affected osci…
View article: Stability from subspace rotations and traveling waves
Stability from subspace rotations and traveling waves Open
Cortical activity shows stability, including the ability to recover from disruptions. We analyzed spiking from the prefrontal cortex (PFC) of monkeys performing working memory tasks with mid-memory-delay distractions. Perturbation of corte…
View article: State-space trajectories and traveling waves following distraction
State-space trajectories and traveling waves following distraction Open
Cortical activity shows the ability to recover from distractions. We analyzed neural activity from the prefrontal cortex (PFC) of monkeys performing working memory tasks with mid-memory-delay distractions (a cued gaze shift or an irrelevan…
View article: Propofol anesthesia destabilizes neural dynamics across cortex
Propofol anesthesia destabilizes neural dynamics across cortex Open
Every day, hundreds of thousands of people undergo general anesthesia. One hypothesis is that anesthesia disrupts dynamic stability, the ability of the brain to balance excitability with the need to be stable and thus controllable. We test…
View article: Multifunctional fibers enable modulation of cortical and deep brain activity during cognitive behavior in macaques
Multifunctional fibers enable modulation of cortical and deep brain activity during cognitive behavior in macaques Open
Recording and modulating neural activity in vivo enables investigations of the neurophysiology underlying behavior and disease. However, there is a dearth of translational tools for simultaneous recording and localized receptor-specific mo…
View article: Closed-loop control of anesthetic state in nonhuman primates
Closed-loop control of anesthetic state in nonhuman primates Open
Research in human volunteers and surgical patients has shown that unconsciousness under general anesthesia can be reliably tracked using real-time electroencephalogram processing. Hence, a closed-loop anesthesia delivery (CLAD) system that…
View article: Propofol-mediated loss of consciousness disrupts predictive routing and local field phase modulation of neural activity
Propofol-mediated loss of consciousness disrupts predictive routing and local field phase modulation of neural activity Open
Predictive coding is a fundamental function of the cortex. The predictive routing model proposes a neurophysiological implementation for predictive coding. Predictions are fed back from deep-layer cortex via alpha/beta (8-30Hz) oscillation…
View article: Multifunctional fibers enable modulation of cortical and deep brain activity during cognitive behavior in macaques
Multifunctional fibers enable modulation of cortical and deep brain activity during cognitive behavior in macaques Open
Recording and modulating neural activity in vivo enables investigations of neural circuits during behavior. However, there is a dearth of tools for simultaneous recording and localized receptor modulation in large animal models. We address…
View article: Propofol anesthesia alters cortical traveling waves
Propofol anesthesia alters cortical traveling waves Open
Oscillatory dynamics in cortex seem to organize into traveling waves that serve a variety of functions. Recent studies show that propofol, a widely used anesthetic, dramatically alters cortical oscillations by increasing slow-delta oscilla…
View article: Propofol Anesthesia Alters Cortical Traveling Waves
Propofol Anesthesia Alters Cortical Traveling Waves Open
Oscillatory dynamics in cortex seem to organize into traveling waves that serve a variety of functions. Recent studies show that propofol, a widely used anesthetic, dramatically alters cortical oscillations by increasing slow-delta oscilla…
View article: Closed-Loop Control of Anesthetic State in Non-Human Primates
Closed-Loop Control of Anesthetic State in Non-Human Primates Open
Continuous monitoring of electroencephalogram (EEG) recordings in humans under general anesthesia (GA) has demonstrated that changes in EEG dynamics induced by an anesthetic drug are reliably associated with the altered arousal states caus…
View article: A hidden Markov model reliably characterizes ketamine-induced spectral dynamics in macaque local field potentials and human electroencephalograms
A hidden Markov model reliably characterizes ketamine-induced spectral dynamics in macaque local field potentials and human electroencephalograms Open
Ketamine is an NMDA receptor antagonist commonly used to maintain general anesthesia. At anesthetic doses, ketamine causes high power gamma (25-50 Hz) oscillations alternating with slow-delta (0.1-4 Hz) oscillations. These dynamics are rea…
View article: Neural effects of propofol-induced unconsciousness and its reversal using thalamic stimulation
Neural effects of propofol-induced unconsciousness and its reversal using thalamic stimulation Open
The specific circuit mechanisms through which anesthetics induce unconsciousness have not been completely characterized. We recorded neural activity from the frontal, parietal, and temporal cortices and thalamus while maintaining unconscio…
View article: Interhemispheric transfer of working memories
Interhemispheric transfer of working memories Open
SUMMARY Visual working memory (WM) storage is largely independent between the left and right visual hemifields/cerebral hemispheres, yet somehow WM feels seamless. We studied how WM is integrated across hemifields by recording neural activ…
View article: Neural effects of propofol-induced unconsciousness and its reversal using thalamic stimulation
Neural effects of propofol-induced unconsciousness and its reversal using thalamic stimulation Open
The specific circuit mechanisms through which anesthetics induce unconsciousness have not been completely characterized. We recorded neural activity from the frontal, parietal, and temporal cortices and thalamus while maintaining unconscio…
View article: Neural signatures of loss of consciousness and its recovery by thalamic stimulation
Neural signatures of loss of consciousness and its recovery by thalamic stimulation Open
We know that general anesthesia produces unconsciousness but not quite how. We recorded neural activity from the frontal, parietal, and temporal cortices and thalamus while maintaining unconsciousness in non-human primates (NHPs) with prop…