Meredith S. Carson
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View article: Data from Weight Loss Reverses the Effects of Aging and Obesity on Mammary Tumor Immunosuppression and Progression
Data from Weight Loss Reverses the Effects of Aging and Obesity on Mammary Tumor Immunosuppression and Progression Open
Advanced age and obesity are major risk factors for breast cancer progression, including triple-negative breast cancer (TNBC). In this study, we interrogated (i) whether these factors interact to promote TNBC progression and (ii) whether w…
View article: Figure S5 from Weight Loss Reverses the Effects of Aging and Obesity on Mammary Tumor Immunosuppression and Progression
Figure S5 from Weight Loss Reverses the Effects of Aging and Obesity on Mammary Tumor Immunosuppression and Progression Open
Figure S5 shows GSEA comparing tumors from Young Con AL mice with those of Young DIO ICR, Young DIO CCR, and Young DIO AL-LFD (GSE272329).
View article: Figure S2 from Weight Loss Reverses the Effects of Aging and Obesity on Mammary Tumor Immunosuppression and Progression
Figure S2 from Weight Loss Reverses the Effects of Aging and Obesity on Mammary Tumor Immunosuppression and Progression Open
Figure S2 shows tumor growth over time following various interventions.
View article: Figure S3 from Weight Loss Reverses the Effects of Aging and Obesity on Mammary Tumor Immunosuppression and Progression
Figure S3 from Weight Loss Reverses the Effects of Aging and Obesity on Mammary Tumor Immunosuppression and Progression Open
Figure S3 shows GSEA comparing tumors from Young DIO AL mice with those of all other AL groups.
View article: Figure S4 from Weight Loss Reverses the Effects of Aging and Obesity on Mammary Tumor Immunosuppression and Progression
Figure S4 from Weight Loss Reverses the Effects of Aging and Obesity on Mammary Tumor Immunosuppression and Progression Open
Figure S4 shows GSEA comparing tumors from Young Con ICR mice with those of all other ICR groups.
View article: Figure S1 from Weight Loss Reverses the Effects of Aging and Obesity on Mammary Tumor Immunosuppression and Progression
Figure S1 from Weight Loss Reverses the Effects of Aging and Obesity on Mammary Tumor Immunosuppression and Progression Open
Figure S1 shows markers of metabolic health and inflammation in before and after weight loss.
View article: Development and Characterization of Syngeneic Orthotopic Transplant Models of Obesity-Responsive Triple-Negative Breast Cancer in C57BL/6J Mice
Development and Characterization of Syngeneic Orthotopic Transplant Models of Obesity-Responsive Triple-Negative Breast Cancer in C57BL/6J Mice Open
Obesity is an established risk and progression factor for triple-negative breast cancer (TNBC), but preclinical studies to delineate the mechanisms underlying the obesity-TNBC link as well as strategies to break that link are constrained b…
View article: Modeling human heterogeneity of obesity with diversity outbred mice reveals a fat mass-dependent therapeutic window for resolvin E1
Modeling human heterogeneity of obesity with diversity outbred mice reveals a fat mass-dependent therapeutic window for resolvin E1 Open
Resolvin E1 (RvE1), a specialized pro-resolving mediator (SPM), improves glucose homeostasis in inbred mouse models of obesity. However, an impediment toward translation is that obesity is a highly heterogenous disease in which individuals…
View article: Development and Characterization of Syngeneic Orthotopic Transplant Models of Obesity-Responsive Triple-Negative Breast Cancer in C57BL/6J Mice
Development and Characterization of Syngeneic Orthotopic Transplant Models of Obesity-Responsive Triple-Negative Breast Cancer in C57BL/6J Mice Open
Obesity is an established risk and progression factor for triple-negative breast cancer (TNBC), but preclinical studies to delineate the mechanisms underlying the obesity-TNBC link as well as strategies to break that link are constrained b…
View article: Separate and combined effects of advanced age and obesity on mammary adipose inflammation, immunosuppression and tumor progression in mouse models of triple negative breast cancer
Separate and combined effects of advanced age and obesity on mammary adipose inflammation, immunosuppression and tumor progression in mouse models of triple negative breast cancer Open
Introduction Advanced age and obesity are independent risk and progression factors for triple negative breast cancer (TNBC), which presents significant public health concerns for the aging population and its increasing burden of obesity. D…
View article: The obesity-breast cancer link: a multidisciplinary perspective
The obesity-breast cancer link: a multidisciplinary perspective Open
View article: Modeling human heterogeneity of obesity with diversity outbred mice reveals a fat mass‐dependent therapeutic window for resolvin E1
Modeling human heterogeneity of obesity with diversity outbred mice reveals a fat mass‐dependent therapeutic window for resolvin E1 Open
Resolvin E1 (RvE1), a specialized pro‐resolving mediator (SPM), improves glucose homeostasis in inbred mouse models of obesity. However, an impediment toward translation is that obesity is a highly heterogenous disease in which individuals…
View article: Mechanistic Targets and Nutritionally Relevant Intervention Strategies to Break Obesity–Breast Cancer Links
Mechanistic Targets and Nutritionally Relevant Intervention Strategies to Break Obesity–Breast Cancer Links Open
The worldwide prevalence of overweight and obesity has tripled since 1975. In the United States, the percentage of adults who are obese exceeds 42.5%. Individuals with obesity often display multiple metabolic perturbations, such as insulin…
View article: High-fat diet-fed ovariectomized mice are susceptible to accelerated subcutaneous tumor growth potentially through adipose tissue inflammation, local insulin-like growth factor release, and tumor associated macrophages
High-fat diet-fed ovariectomized mice are susceptible to accelerated subcutaneous tumor growth potentially through adipose tissue inflammation, local insulin-like growth factor release, and tumor associated macrophages Open
This work provides evidences suggesting adiposity, adipose specific IGF-1, macrophage associated adipose inflammation, and TAMs as potential mechanisms driving obesity-enhanced CRC in females lacking ovarian hormones.
View article: Prolonged high-fat-diet feeding promotes non-alcoholic fatty liver disease and alters gut microbiota in mice
Prolonged high-fat-diet feeding promotes non-alcoholic fatty liver disease and alters gut microbiota in mice Open
Overall, these data suggest that chronic HFD consumption in mice can mimic pathophysiological and some microbial events observed in NAFLD patients.
View article: Impact of 5 fluorouracil chemotherapy on gut inflammation, functional parameters, and gut microbiota
Impact of 5 fluorouracil chemotherapy on gut inflammation, functional parameters, and gut microbiota Open
View article: The Contribution of Adipose Tissue from Ovariectomized Mice to Colon Cancer
The Contribution of Adipose Tissue from Ovariectomized Mice to Colon Cancer Open
Obesity is considered a major public health concern worldwide due to the increased incidences of metabolic dysfunction and cancer risk. The obese state is, in part, attributable to the overconsumption of calorie-dense foods commonly seen i…
View article: Repeated clodronate-liposome treatment results in neutrophilia and is not effective in limiting obesity-linked metabolic impairments
Repeated clodronate-liposome treatment results in neutrophilia and is not effective in limiting obesity-linked metabolic impairments Open
Depletion of macrophages is thought to be a therapeutic option for obesity-induced inflammation and metabolic dysfunction. However, whether the therapeutic effect is a direct result of reduced macrophage-derived inflammation or secondary t…
View article: Macrophage depletion using clodronate liposomes decreases tumorigenesis and alters gut microbiota in the AOM/DSS mouse model of colon cancer
Macrophage depletion using clodronate liposomes decreases tumorigenesis and alters gut microbiota in the AOM/DSS mouse model of colon cancer Open
We examined the role of macrophages in inflammation associated with colorectal cancer (CRC). Given the emerging evidence on immune-microbiota interactions in CRC, we also sought to examine the interaction between macrophages and gut microb…
View article: miR155 deficiency aggravates high-fat diet-induced adipose tissue fibrosis in male mice
miR155 deficiency aggravates high-fat diet-induced adipose tissue fibrosis in male mice Open
Noncoding RNAs are emerging as regulators of inflammatory and metabolic processes. There is evidence to suggest that miRNA155 (miR155) may be linked to inflammation and processes associated with adipogenesis. We examined the impact of glob…
View article: Loss of monocyte chemoattractant protein-1 expression delays mammary tumorigenesis and reduces localized inflammation in the C3(1)/SV40Tag triple negative breast cancer model
Loss of monocyte chemoattractant protein-1 expression delays mammary tumorigenesis and reduces localized inflammation in the C3(1)/SV40Tag triple negative breast cancer model Open
Monocyte chemoattractant protein 1 (MCP-1) has been implicated as a major modulator in the progression of mammary tumorigenesis, largely due to its ability to recruit macrophages to the tumor microenvironment. Macrophages are key mediators…
View article: A Low Dose of Dietary Quercetin Fails to Protect against the Development of an Obese Phenotype in Mice
A Low Dose of Dietary Quercetin Fails to Protect against the Development of an Obese Phenotype in Mice Open
The purpose of this study was to examine the effect of a 40% high-fat diet (HFD) supplemented with a dietary attainable level of quercetin (0.02%) on body composition, adipose tissue (AT) inflammation, Non-Alcoholic Fatty-Liver Disease (NA…
View article: Weight loss following diet-induced obesity does not alter colon tumorigenesis in the AOM mouse model
Weight loss following diet-induced obesity does not alter colon tumorigenesis in the AOM mouse model Open
Obesity presents a significant public health concern given its association with increased cancer incidence, unfavorable prognosis, and metastasis. However, there is very little literature on the effects of weight loss, following obesity, o…