Merete Heitmann
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Optimizing Diagnostic Resource Use in Suspected Chronic coronary Syndrome: Pre-Test Probability and Acoustic CAD rule-out in the FILTER-SCAD Trial Open
Background and aim The FILTER-SCAD trial combined pre-test-probability (PTP) and the FDA-cleared CAD-Score System to guide and improve deferred testing in suspected chronic coronary syndrome (CCS). However, adherence to the recommended str…
View article: Acoustic-based rule-out of stable coronary artery disease: the FILTER-SCAD trial
Acoustic-based rule-out of stable coronary artery disease: the FILTER-SCAD trial Open
Background and Aims Overtesting of low-risk patients with suspect chronic coronary syndrome (CCS) is widespread. The acoustic-based coronary artery disease (CAD)-score has superior rule-out capabilities when added to pre-test probability (…
View article: Use of combination therapy is associated with improved LDL cholesterol management: 1-year follow-up results from the European observational SANTORINI study
Use of combination therapy is associated with improved LDL cholesterol management: 1-year follow-up results from the European observational SANTORINI study Open
Aims To assess whether implementation of the 2019 European Society of Cardiology (ESC)/European Atherosclerosis Society (EAS) dyslipidaemia guidelines observed between 2020 and 2021 improved between 2021 and 2022 in the SANTORINI study. Me…
View article: The importance of nonobstructive plaque characteristics in symptomatic and asymptomatic coronary artery disease
The importance of nonobstructive plaque characteristics in symptomatic and asymptomatic coronary artery disease Open
Nonobstructive CAD was the predominant contributor to total atherosclerotic plaque volume in both subclinical and clinically manifested CAD. Nonobstructive fibrous, fibrofatty and necrotic core tissue volumes increased with worsening clini…
Prevalence and management of familial hypercholesterolaemia in patients with chest pain admitted to hospital: a retrospective observational study Open
Objectives Patients with familial hypercholesterolaemia (FH) are genetically burdened by a lifelong elevation of the low-density lipoprotein cholesterol (LDL-C) level, putting them at a very high risk of premature ischaemic heart disease (…
View article: Genetic testing increases the likelihood of a diagnosis of familial hypercholesterolaemia among people referred to lipid clinics: Danish national study
Genetic testing increases the likelihood of a diagnosis of familial hypercholesterolaemia among people referred to lipid clinics: Danish national study Open
In a Danish nationwide study, genetic testing increased a diagnosis of FH from 22% to 37% in patients referred with hypercholesterolaemia suspected of having FH. Importantly, approximately 20% with unlikely or possible FH, who without gene…
Cost-effectiveness of adding a non-invasive acoustic rule-out test in the evaluation of patients with symptoms suggestive of coronary artery disease: rationale and design of the prospective, randomised, controlled, parallel-group multicenter FILTER-SCAD trial Open
Introduction Most patients with symptoms suggestive of chronic coronary syndrome (CCS) have no obstructive coronary artery disease (CAD) and better selection of patients to be referred for diagnostic tests is needed. The CAD-score is a non…
Screening for potential familial hypercholesterolaemia in general practice: an observational study on prevalence and management Open
Background Familial hypercholesterolaemia (FH) is a common genetic disorder causing premature cardiovascular disease (CVD). The estimated prevalence of probable or definite FH is 1:200–250 individuals, according to the Dutch Lipid Clinic N…
Coronary risk of patients with valvular heart disease: prospective validation of CT-Valve Score Open
Objective To prospectively validate the CT-Valve score, a new risk score designed to identify patients with valvular heart disease at a low risk of coronary artery disease (CAD) who could benefit from multislice CT (MSCT) first instead of …
Coronary risk stratification of patients with newly diagnosed heart failure Open
Objective Coronary artery disease (CAD) is frequent in patients with newly diagnosed heart failure (HF). Multislice CT (MSCT) is a non-invasive alternative to coronary angiography (CAG) suggested for patients with a low-to-intermediate ris…
View article: Low diagnostic yield of non-invasive testing in patients with suspected coronary artery disease: results from a large unselected hospital-based sample
Low diagnostic yield of non-invasive testing in patients with suspected coronary artery disease: results from a large unselected hospital-based sample Open
These data confirm the very low diagnostic yield of non-invasive and invasive assessment of CAD in current clinical practice, particularly in women and in patients with atypical symptoms. Data call for a more rational approach to avoid unn…