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Electroconvulsive therapy and occupational functioning in individuals with major depression Open
ECT was linked to delayed short-term occupational recovery, but comparable or improved long-term return to work, supporting its continued use in treating major depression.
Protocol for: Association of antipsychotic medication usage and employment outcomes in patients with schizophrenia spectrum disorders: A Danish register-based study Open
Background Schizophrenia spectrum disorders are associated with higher risk of unemployment for the individual. Antipsychotic usage is linked to less risk of relapse, fewer hospitalisations and lower rates of mortality. This study investig…
View article: A life course perspective on predictors of midlife socioeconomic status
A life course perspective on predictors of midlife socioeconomic status Open
Background Previous studies have found paternal occupation, childhood intelligence, and educational attainment to be important predictors of socioeconomic status (SES) later in life. However, these factors only explain part of the variance…
View article: Maternal anxiety or depression and cognitive ability in young male offspring: A population-based cohort study using cognitive test scores from the Danish Conscription Board Examination
Maternal anxiety or depression and cognitive ability in young male offspring: A population-based cohort study using cognitive test scores from the Danish Conscription Board Examination Open
Purpose We aimed to study how the timing of incident maternal emotional disorders is associated with male offspring's cognitive ability in early adulthood using cognitive test data from military conscription in a population-based cohort. M…
Risk of Dementia in Patients Suffering From Psychosis—A Danish Register‐Based Cohort Study Open
Objective To investigate the association of psychosis with subsequent risk of dementia and to explore any impact of age at psychosis onset. Methods Using the Danish National health registries, a total of 39,022 patients with a diagnosis of…
View article: Child characteristics and parents' risk of depression in old age: The impact of number, sex and educational attainment
Child characteristics and parents' risk of depression in old age: The impact of number, sex and educational attainment Open
Availability and characteristics, especially educational attainment, of adult children were identified to be associated with their parent's probability of being with depression in old age.
All‐Cause and Cause‐Specific Mortality Among Individuals With Major Depression: A Nationwide Danish Matched‐Cohort Study Open
Background Mental disorders are associated with excess risk of death from unnatural and natural causes, but few studies have differentiated causes of death among patients with major depression. We examined cumulative and relative risks of …
The impact of family depression history and childhood adversities on the risk of depression in adulthood among 1,461,034 individuals Open
Individuals exposed to family MD history and CAs are at increased risk of MD. However, the associations between family MD and onset of MD in adulthood remain largely unchanged regardless of the presence of any of the ten CAs.
Prescription sequences in bipolar disorder – A nationwide Danish register-based study of 19,927 individuals followed for 10 years Open
Evidence-based use of pharmacological interventions in bipolar disorder is of paramount clinical importance. We aimed to uncover precription sequences in a large cohort of patients from the first diagnosis of bipolar disorder. Using Danish…
The cerebral blood flow response to neuroactivation is reduced in cognitively normal men with β-amyloid accumulation Open
We found a correlation between high PiB SUVr and reduced CBF response to neuronal activation, indicating a link between Aβ accumulation and impaired cerebrovascular function. The impairment was not associated with cortical thinning or hypo…
Diagnostic trajectories and stability of mental disorders in childhood and adolescence – A nation-wide cohort study using sequence analysis Open
Background Little is known about the diagnostic trajectories following a first psychiatric diagnosis in childhood or adolescence. Such knowledge could aid clinicians in treatment, risk prediction, and psychoeducation. This study presents a…
View article: Cognitive aging and reserve factors in the Metropolit 1953 Danish male cohort
Cognitive aging and reserve factors in the Metropolit 1953 Danish male cohort Open
Identifying early predictors of cognitive decline and at-risk individuals is essential for timely intervention and prevention of dementia. This study aimed to detect neurobiological changes and factors related to cognitive performance in t…
View article: Cannabis Use and Age‐Related Changes in Cognitive Function From Early Adulthood to Late Midlife in 5162 Danish Men
Cannabis Use and Age‐Related Changes in Cognitive Function From Early Adulthood to Late Midlife in 5162 Danish Men Open
Introduction Cannabis is by far the most widely used and abused drug listed on the Drug Enforcement Administration's Schedule I, which includes drugs with a high potential for abuse. There is evidence of short‐term negative effects of cann…
Differences in Associations of Three Types of Alcoholic Beverages with Age-Related Cognitive Decline in Men Open
Objectives: To investigate the influence of wine, beer, and spirits consumption, respectively, on non-pathological, age-related cognitive decline from young adulthood to late midlife in a large follow-up study of Danish men. Methods: The s…
View article: Associations of benzodiazepine use with cognitive ability and age-related cognitive decline
Associations of benzodiazepine use with cognitive ability and age-related cognitive decline Open
Background It remains uncertain whether long-term use of benzodiazepines is associated with age-related cognitive decline, and if cognitive ability in early life is the driver of any association. This study examines the association of cogn…
Clinical Outcomes of Continuation and Maintenance Electroconvulsive Therapy Open
Importance Large-scale evidence for the efficacy of continuation and maintenance electroconvulsive therapy (c/mECT) is lacking. Objective To provide an exhaustive and naturalistic insight into the real-world outcomes and the cost-effective…
Association of early- and late-life bipolar disorder with incident dementia. A Danish cohort study Open
Individuals with bipolar disorder have a higher risk of developing dementia compared to a reference population without bipolar disorder, independent of the age at the onset of bipolar disorder.
Risk of Bowel Obstruction After Hysterectomy for Benign Indication According to Surgical Method in Denmark, 1984–2013 Open
Abdominal hysterectomy is associated with a 54% higher risk of BO than minimally invasive (laparoscopic or vaginal) hysterectomy.
Inverse probability weighting for self-selection bias correction in the investigation of social inequality in mortality Open
Background Empirical evaluation of inverse probability weighting (IPW) for self-selection bias correction is inaccessible without the full source population. We aimed to: (i) investigate how self-selection biases frequency and association …
Causal discovery and epidemiology: a potential for synergy Open
Introduction We wish to applaud the insightful commentary provided by Didelez1 on our comparative study of data-driven versus theory-driven approaches for constructing causal life-course models.2 Didelez’ concise and honest description of …
Adverse Pregnancy Outcomes and Subsequent First-Time Use of Psychiatric Treatment Among Fathers in Denmark Open
Importance Becoming a first-time parent is a major life-changing event and can be challenging regardless of the pregnancy outcome. However, little is known how different adverse pregnancy outcomes affect the father’s risk of psychiatric tr…
Cohort Profile Update: The Glostrup Population Studies 1964–2024 Open
Journal Article Cohort Profile Update: The Glostrup Population Studies 1964–2024 Get access Line Tang Møllehave, Line Tang Møllehave Center for Clinical Research and Prevention, Copenhagen University Hospital—Bispebjerg and Frederiksberg, …
Use of antipsychotic medication, benzodiazepines, and psychiatric hospitalization in cannabis-related versus cannabis-unrelated schizophrenia – a nationwide, register-based cohort study Open
Background Evidence suggests that cannabis may be a causal factor for development of schizophrenia. We aimed to investigate whether use of antipsychotic medication, benzodiazepines, and psychiatric service use differs among patients with s…
View article: The cerebral blood flow response to neuroactivation is reduced in cognitively normal men with β-amyloid accumulation
The cerebral blood flow response to neuroactivation is reduced in cognitively normal men with β-amyloid accumulation Open
Background Accumulation of β-amyloid (Aβ) in the brain is a hallmark of Alzheimer’s Disease (AD). Cerebral deposition of Aβ initiates deteriorating pathways which eventually can lead to AD. However, the exact mechanisms are not known. A po…
The Danish Aging and Cognition (DanACo) cohort Open
Background With aging populations worldwide, identification of predictors of age-related cognitive decline is becoming increasingly important. The Danish Aging and Cognition Cohort (DanACo) including more than 5000 Danish men was establish…
Sedative drug prescription patterns in Danish adults from 2002 through 2021. A register-based cohort study Open
Sedative drug prescriptions are distributed on different drug classes, with Z-drugs and anxiolytic benzodiazepines as the most frequent first treatment, and second choice in case of shift.