Explanipedia

Prevalence of thrombocytopenia in children with dengue fever in a tertiary care hospital Open

Sushma Kunwar, Askal Devkota, Prapti Shrestha, Amuda Regmi, Merina Shrestha , et al. · 2025

Background Dengue fever is an arthropod borne viral disease transmitted by bite of infected mosquito Aedes aegypti. Almost half of the world population is in risk of dengue and in Nepal dengue fever is endemic and infection occurs each yea…

Morbidity and Mortality Pattern in NICU of Tertiary Care Hospital: A Retrospective Study Open

Sushma Kunwar, Askal Devkota, Manisha Ghimire, Prapti Shrestha, Amuda Regmi , et al. · 2025

Introduction: Neonatal period is a very vulnerable period of life as it accounts for high morbidity and mortality and most diseases common in neonatal period are preventable. Objective of this study was to analyze the pattern of morbidity …

Leveraging Genetic Correlations to Prioritize Drug Groups for Repurposing in Type 2 Diabetes Open

Astrid Johannesson Hjelholt, Tahereh Gholipourshahraki, Zhonghao Bai, Merina Shrestha, Mads Kjoelby , et al. · 2025

Type 2 diabetes (T2D) is a complex, polygenic disease with substantial health impact. Despite extensive genome-wide association studies (GWAS) identifying risk loci, therapeutic translation remains limited. We applied a Bayesian Linear Reg…

The Association Between Prenatal Maternal Selenium Concentration and Neurodevelopment in Early Childhood, Results from a Mother–Child Cohort Study Open

Suman Ranjitkar, Ingrid Kvestad, Ram K. Chandyo, Tor A. Strand, Kjersti Bakken , et al. · 2025

Social withdrawal behaviour in Nepalese infants and the relationship with future neurodevelopment; a longitudinal cohort study Open

Ingrid Kvestad, Manjeswori Ulak, Suman Ranjitkar, Merina Shrestha, Ram K. Chandyo , et al. · 2024

Background Social withdrawal in infants may be a signal of distress and a precursor for non-optimal development. Objective To examine the relationship between infant social withdrawal and neurodevelopment up to 4 years in Nepalese children…

Sleep characteristics and changes in sleep patterns among infants in Bhaktapur, Nepal Open

Ram K. Chandyo, Suman Ranjitkar, Jaya S. Silpakar, Manjeswori Ulak, Ingrid Kvestad , et al. · 2024

Cosleeping was almost universal among Nepalese infants, and very few of the mothers reported sleep problems in their infants. Infants at 6 and 12months had similar patterns for both sleep duration and nocturnal awakenings. For infants, the…

Evaluation of Bayesian Linear Regression Derived Gene Set Test Methods Open

Zhonghao Bai, Tahereh Gholipourshahraki, Merina Shrestha, Astrid Johannesson Hjelholt, Mads Kjølby , et al. · 2024

Gene set tests can pinpoint genes and biological pathways that exert small to moderate effects on complex diseases like Type 2 Diabetes (T2D). By aggregating genetic markers based on biological information, these tests can enhance the stat…

Feasibility of Telemedicine for Follow up of Children with Established Seizure Disorder- A Tertiary Care Center Prospective Study Open

Luna Bajracharya, Merina Shrestha · 2023

Introduction: Medical information exchanged via electronic communications to improve a patient’s clinical health status by a physician without in-patient visit is telemedicine. Control of seizures with antiepileptic drugs, reassurance for …

Abdominal pseudocyst complicating ventriculoperitoneal shunt: A rare indication for ventriculopleural shunt conversion Open

Nishan Shrestha, Naveen Gautam, Merina Shrestha · 2023

Key Clinical Message Abdominal pseudocyst is a rare complication of ventriculoperitoneal (VP) shunt placement. Ventriculopleural shunt (VPL) can be an effective treatment option for the recurrent complications of VP shunt failure. Abstract…

Abdominal pseudocyst complicating ventriculoperitoneal shunt: a rare indication for ventriculopleural shunt conversion Open

Nishan Shrestha, Naveen Gautam, Merina Shrestha · 2023

Abdominal pseudocyst complicating ventriculoperitoneal shunt.docx

P17-060-23 The Effect of Daily B12 Supplementation on the Incidence of Common Childhood Infections in Nepal: Secondary Outcomes From a Double Blind Randomized Controlled Trial Open

Tor A. Strand, Ram K. Chandyo, Adrian McCann, Manjeswswori Ulak, Mari Hysing , et al. · 2023

The reliability and predictive ability of the Test of Infant Motor Performance (TIMP) in a community-based study in Bhaktapur, Nepal Open

Ingrid Kvestad, Jaya S. Silpakar, Mari Hysing, Suman Ranjitkar, Tor A. Strand , et al. · 2023

The reliability of the TIMP was acceptable, and the TIMP could be a feasible tool to monitor infant motor development in low-resource settings. Properties of the TIMP differed according to gestational age.

The Relationship between the Ages and Stages Questionnaire, 3rd Edition Scores in Early Childhood and Future Cognitive Abilities in Young Nepalese Children Open

Merina Shrestha, Suman Ranjitkar, Mari Hysing, Tor A. Strand, Manjeswori Ulak , et al. · 2023

Vitamin B12 Supplementation In Pregnancy and Infant Growth and Development - A Community-Based Double-Blind Randomised Trial Open

Ram K. Chandyo, Ingrid Kvestad, M Ulak, Suman Ranjitkar, Mari Hysing , et al. · 2023

Associations between biomass fuel use and child health: a community-based study in Bhaktapur, Nepal Open

Catherine Schwinger, Ingrid Kvestad, RK Chandyo, Mari Hysing, M Ulak , et al. · 2022

Background Biomass fuel use for cooking is widespread in low- and middle-income countries. Previous studies have mainly focused on adverse health outcomes in adults or specific diseases. In a cohort among young children living in Bhaktapur…

The association between household biomass fuel use and leukocyte telomere length among toddlers in Bhaktapur, Nepal Open

Ram K. Chandyo, Catherine Schwinger, Ingrid Kvestad, Manjeswori Ulak, Suman Ranjitkar , et al. · 2022

The stability of the Bayley scales in early childhood and its relationship with future intellectual abilities in a low to middle income country Open

Ingrid Kvestad, Mari Hysing, Suman Ranjitkar, Merina Shrestha, Manjeswori Ulak , et al. · 2022

The stability of the Bayley scales is poor in early childhood, and its relationship with future intellectual abilities is poor in infancy but improves slightly with age in early childhood. Findings from this large community-based cohort of…

Biomass fuel use for cooking in Nepalese families and child cognitive abilities, results from a community-based study Open

Ingrid Kvestad, Ram K. Chandyo, Catherine Schwinger, Suman Ranjitkar, Mari Hysing , et al. · 2022

Biomass fuel use for cooking in Nepalese families was associated with lower overall cognitive abilities at 4 years. Uncertainties include exposure misclassification and unmeasured confounding. The associations between biomass fuel use and …

Impact of the COVID-19 pandemic on daily life and worry among mothers in Bhaktapur, Nepal Open

Suman Ranjitkar, Tor A. Strand, Manjeswori Ulak, Ingrid Kvestad, Merina Shrestha , et al. · 2022

The COVID-19 pandemic has affected many aspects of daily life worldwide, but the impact may be higher for impoverished populations. The main aim of this study is to describe the impact of the COVID-19 pandemic on different aspects of daily…

The association between biomass fuel use for cooking and linear growth in young children in Bhaktapur, Nepal Open

Catherine Schwinger, Ingrid Kvestad, Ram K. Chandyo, Manjeswori Ulak, Merina Shrestha , et al. · 2022

Children from households in poor, urban neighborhoods in Nepal which used biomass fuel for cooking were on average slightly shorter than other children, although the association only approached statistical significance. As this was an obse…

The effect of vitamin B12-supplementation on actigraphy measured sleep pattern; a randomized control trial Open

Mari Hysing, Tor A. Strand, Ram K. Chandyo, Manjeswori Ulak, Suman Ranjitkar , et al. · 2021

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Maternal depression is associated with less dietary diversity among rural Nepali children Open

Laurie C. Miller, Sumanta Neupane, Thalia Sparling, Merina Shrestha, Neena Joshi , et al. · 2021

Maternal depression has been associated with adverse child growth and development; less is known about its relation to children's diet. In a cross‐sectional study embedded at endline of a longitudinal community development intervention, mo…

Cobalamin and folate status in women during early pregnancy in Bhaktapur, Nepal Open

Catherine Schwinger, Shakun Sharma, Ram K. Chandyo, Mari Hysing, Ingrid Kvestad , et al. · 2021

The demand for cobalamin (vitamin B12) and folate is increased during pregnancy, and deficiency during pregnancy may lead to complications and adverse outcomes. Yet, the status of these micronutrients is unknown in many populations. We ass…

Effects of vitamin B12 supplementation on neurodevelopment and growth in Nepalese Infants: A randomized controlled trial Open

Tor A. Strand, Manjeswori Ulak, Mari Hysing, Suman Ranjitkar, Ingrid Kvestad , et al. · 2020

Background Vitamin B 12 deficiency is common and affects cell division and differentiation, erythropoiesis, and the central nervous system. Several observational studies have demonstrated associations between biomarkers of vitamin B 12 sta…

One-Carbon Metabolism in Nepalese Infant–Mother Pairs and Child Cognition at 5 Years Old Open

Ingrid Kvestad, Adrian McCann, Ram K. Chandyo, Lasse M. Giil, Merina Shrestha , et al. · 2020

Agreement Between Mothers and Fieldworkers While Assessing Child Development Using Ages and Stages Questionnaires, Third Edition in Nepal Open

Merina Shrestha, Catherine Schwinger, Mari Hysing, Ram K. Chandyo, Manjeswori Ulak , et al. · 2020

Background: The Ages and Stages Questionnaires, Third Edition (ASQ-3) is becoming a widely used developmental assessment tool. The ASQ-3 can be completed by the caregivers (referred to as "mail out"), or by trained personnel under d…

Prevalence of Underweight, Overweight, and Obesity in Adults in Bhaktapur, Nepal in 2015–2017 Open

Catherine Schwinger, Ram K. Chandyo, Manjeswori Ulak, Mari Hysing, Merina Shrestha , et al. · 2020

Introduction: There is an increase in the double burden of malnutrition globally, with a particular rise documented in Asia. In Nepal, undernutrition has been prevalent for decades. Today, however, the incidence of overweight and ob…

Leigh Syndrome in an Adolescent Girl: A Case Report Open

Merina Shrestha, Luna Bajracharya, Sudha Basnet · 2020

Leigh syndrome (LS) is a disorder of infancy and rarely late childhood. It presents with regression of mental and motor skills. Here, we present LS in an adolescent girl who presented with generalized dystonia and cognitive decline. Her in…

The Feasibility of the Full and Modified Versions of the Alarm Distress Baby Scale (ADBB) and the Prevalence of Social Withdrawal in Infants in Nepal Open

Manjeswori Ulak, Suman Ranjitkar, Merina Shrestha, Hanne Cecilie Braarud, Ram K. Chandyo , et al. · 2020

Our findings suggest that the m-ADBB is an acceptable approach to achieve adequate interrater agreement in a large community-based study in Nepal. Results indicate high prevalence of social withdrawal in this population. There are, however…

Breastfeeding Pattern and its Associated Factors Among Mothers Working at Two Hospitals in Kathmandu Open

Srijana Basnet, Merina Shrestha, Tulashi Adhikari, Aarati Shakya · 2020

Introduction: Breastfeeding practices of women working at the hospital are likely to be modified by the facilities and support that they receive at the hospital. This study was done to evaluate the breast feeding practices and to analyse i…

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