Merlin D. Larson
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View article: The Pupillary Light-Off Reflex in Acute Disorders of Consciousness
The Pupillary Light-Off Reflex in Acute Disorders of Consciousness Open
Background In intensive care patients with disorders of consciousness, the pupillary light reflex is a measure of pupillary parasympathetic function. By contrast, the pupillary light-off reflex leads to pupil dilation in response to an abr…
View article: The pupillary dark reflex in acute disorders of consciousness
The pupillary dark reflex in acute disorders of consciousness Open
Background. In intensive care patients with disorders of consciousness (DoC), the pupillary light reflex is a measure of pupillary parasympathetic function. By contrast, the pupillary dark reflex leads to pupil dilation in response to dark…
View article: Overcoming Obstacles: The Legacy of Fidel Pagés, Founder of the Epidural, 100 Years After His Passing
Overcoming Obstacles: The Legacy of Fidel Pagés, Founder of the Epidural, 100 Years After His Passing Open
Fidel Pagés, a Spanish surgeon, tragically died in 1923 at the age of 37, just 2 years after his publication “Anestesia Metamérica,” the first description of human thoracolumbar epidural anesthesia. In the intervening 100 years, epidural a…
View article: Brimonidine eye drops reveal diminished sympathetic pupillary tone in comatose patients with brain injury
Brimonidine eye drops reveal diminished sympathetic pupillary tone in comatose patients with brain injury Open
Background There is an urgent need for easy-to-perform bedside measures to detect residual consciousness in clinically unresponsive patients with acute brain injury. Interestingly, the sympathetic control of pupil size is thought to be los…
Evaluation of two portable pupillometers to assess clinical utility Open
Background: Pupillometers have been proposed as clinical assessment tools. We compared two pupillometers to assess measurement agreement. Materials & methods: We enrolled 30 subjects and simultaneously measured the pupil diameter and light…
Peer Review #1 of "Automated pupillometry to detect command following in neurological patients: a proof-of-concept study (v0.1)" Open
Background: Levels of consciousness in patients with acute and chronic brain injury are notoriously underestimated.Paradigms based on electroencephalography (EEG) and functional magnetic resonance imaging (fMRI) may detect covert conscious…
Peer Review #1 of "Automated pupillometry to detect command following in neurological patients: a proof-of-concept study (v0.4)" Open
Background: Levels of consciousness in patients with acute and chronic brain injury are notoriously underestimated.Paradigms based on electroencephalography (EEG) and functional magnetic resonance imaging (fMRI) may detect covert conscious…
Peer Review #1 of "Automated pupillometry to detect command following in neurological patients: a proof-of-concept study (v0.2)" Open
Background: Levels of consciousness in patients with acute and chronic brain injury are notoriously underestimated.Paradigms based on electroencephalography (EEG) and functional magnetic resonance imaging (fMRI) may detect covert conscious…
Peer Review #1 of "Automated pupillometry to detect command following in neurological patients: a proof-of-concept study (v0.3)" Open
Background: Levels of consciousness in patients with acute and chronic brain injury are notoriously underestimated.Paradigms based on electroencephalography (EEG) and functional magnetic resonance imaging (fMRI) may detect covert conscious…