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View article: Unveiling the Emerging Role of Extracellular Vesicle–Inflammasomes in Hyperoxia-Induced Neonatal Lung and Brain Injury
Unveiling the Emerging Role of Extracellular Vesicle–Inflammasomes in Hyperoxia-Induced Neonatal Lung and Brain Injury Open
Extremely premature infants are at significant risk for developing bronchopulmonary dysplasia (BPD) and neurodevelopmental impairment (NDI). Although BPD is a predictor of poor neurodevelopmental outcomes, it is currently unknown how BPD c…
View article: Unveiling the Emerging Role of Extracellular Vesicle-Inflammasome in Hyperoxia-induced Neonatal Lung and Brain Injury
Unveiling the Emerging Role of Extracellular Vesicle-Inflammasome in Hyperoxia-induced Neonatal Lung and Brain Injury Open
Extremely premature infants are at significant risk for developing bronchopulmonary dysplasia (BPD) and neurodevelopmental impairment (NDI). Although BPD is a predictor of poor neurodevelopmental outcomes, it is currently unknown how BPD c…
View article: Neonatal hyperoxia exposure leads to developmental programming of cardiovascular and renal disease in adult rats
Neonatal hyperoxia exposure leads to developmental programming of cardiovascular and renal disease in adult rats Open
View article: Extracellular Vesicle ASC: A Novel Mediator for Lung–Brain Axis in Preterm Brain Injury
Extracellular Vesicle ASC: A Novel Mediator for Lung–Brain Axis in Preterm Brain Injury Open
Bronchopulmonary dysplasia (BPD) and neurodevelopmental impairment are among the most common morbidities affecting preterm infants. Although BPD is a predictor of poor neurodevelopmental outcomes, it is currently uncertain how BPD contribu…
View article: IC100, a humanized therapeutic monoclonal anti-ASC antibody alleviates oxygen-induced retinopathy in mice
IC100, a humanized therapeutic monoclonal anti-ASC antibody alleviates oxygen-induced retinopathy in mice Open
Background Retinopathy of prematurity (ROP), which often presents with bronchopulmonary dysplasia (BPD), is among the most common morbidities affecting extremely premature infants and is a leading cause of severe vision impairment in child…
View article: WCN24-2143 NEONATAL HYPEROXIA EXPOSURE LEADS TO DEVELOPMENTAL PROGRAMMING OF ADULT CARDIOVASCULAR AND RENAL DISEASE
WCN24-2143 NEONATAL HYPEROXIA EXPOSURE LEADS TO DEVELOPMENTAL PROGRAMMING OF ADULT CARDIOVASCULAR AND RENAL DISEASE Open
Premature infants are often exposed to hyperoxia. However, there is a lack of knowledge of the mechanistic underpinnings linking neonatal hyperoxia exposure and its contribution to cardio-renal dysfunction in adults born preterm. Our objec…
View article: c-Myc Drives inflammation of the maternal-fetal interface, and neonatal lung remodeling induced by intra-amniotic inflammation
c-Myc Drives inflammation of the maternal-fetal interface, and neonatal lung remodeling induced by intra-amniotic inflammation Open
Background: Intra-amniotic inflammation (IAI) is associated with increased risk of preterm birth and bronchopulmonary dysplasia (BPD), but the mechanisms by which IAI leads to preterm birth and BPD are poorly understood, and there are no e…
View article: Chorioamnionitis accelerates granule cell and oligodendrocyte maturation in the cerebellum of preterm nonhuman primates
Chorioamnionitis accelerates granule cell and oligodendrocyte maturation in the cerebellum of preterm nonhuman primates Open
View article: Protective role of CXCR7 activation in neonatal hyperoxia-induced systemic vascular remodeling and cardiovascular dysfunction in juvenile rats
Protective role of CXCR7 activation in neonatal hyperoxia-induced systemic vascular remodeling and cardiovascular dysfunction in juvenile rats Open
View article: GSDMD gene knockout alleviates hyperoxia-induced hippocampal brain injury in neonatal mice
GSDMD gene knockout alleviates hyperoxia-induced hippocampal brain injury in neonatal mice Open
View article: Extracellular vesicles: pathogenic messengers and potential therapy for neonatal lung diseases
Extracellular vesicles: pathogenic messengers and potential therapy for neonatal lung diseases Open
Extracellular vesicles (EVs) are a heterogeneous group of nano-sized membranous structures increasingly recognized as mediators of intercellular and inter-organ communication. EVs contain a cargo of proteins, lipids and nucleic acids, and …
View article: GSDMD gene knockout alleviates hyperoxia-induced hippocampal brain injury in neonatal mice
GSDMD gene knockout alleviates hyperoxia-induced hippocampal brain injury in neonatal mice Open
Background: Neonatal hyperoxia exposure is associated with brain injury and poor neurodevelopment outcomes in preterm infants. Our previous studies in neonatal rodent models have shown that hyperoxia stimulates the brain’s inflammasome pat…
View article: Maternal SARS-CoV-2, Placental Changes and Brain Injury in 2 Neonates
Maternal SARS-CoV-2, Placental Changes and Brain Injury in 2 Neonates Open
Long-term neurodevelopmental sequelae are a potential concern in neonates following in utero exposure to severe acute respiratory syndrome coronavirus disease 2 (SARS-CoV-2). We report 2 neonates born to SARS-CoV-2 positive mothers, who di…
View article: GSDMD deficiency ameliorates hyperoxia-induced BPD and ROP in neonatal mice
GSDMD deficiency ameliorates hyperoxia-induced BPD and ROP in neonatal mice Open
View article: Neonatal intermittent hypoxia persistently impairs lung vascular development and induces long-term lung mitochondrial DNA damage
Neonatal intermittent hypoxia persistently impairs lung vascular development and induces long-term lung mitochondrial DNA damage Open
Our current study demonstrates that neonatal intermittent hypoxia (IH) alters lung endothelial cell function, induces mitochondrial DNA lesions, and impairs lung vascular growth into adulthood. Moreover, when superimposed on hyperoxia, neo…
View article: Single-nucleus RNA-seq reveals disrupted cell maturation by chorioamnionitis in the preterm cerebellum of nonhuman primates
Single-nucleus RNA-seq reveals disrupted cell maturation by chorioamnionitis in the preterm cerebellum of nonhuman primates Open
Preterm birth is often associated with chorioamnionitis and increased risk of neurodevelopmental disorders. Preterm birth also leads to cerebellar underdevelopment but the mechanisms of disrupted cerebellar development in preterm infants a…
View article: Educational Review: The Impact of Perinatal Oxidative Stress on the Developing Kidney
Educational Review: The Impact of Perinatal Oxidative Stress on the Developing Kidney Open
Oxidative stress occurs when there is an imbalance between reactive oxygen species/reactive nitrogen species and antioxidant systems. The interplay between these complex processes is crucial for normal pregnancy and fetal development; howe…
View article: Mesenchymal Stem Cell-derived Extracellular Vesicles Prevent Experimental Bronchopulmonary Dysplasia Complicated By Pulmonary Hypertension
Mesenchymal Stem Cell-derived Extracellular Vesicles Prevent Experimental Bronchopulmonary Dysplasia Complicated By Pulmonary Hypertension Open
Mesenchymal stem cell (MSC) extracellular vesicles (EVs) have beneficial effects in preclinical bronchopulmonary dysplasia and pulmonary hypertension (BPD-PH) models. The optimal source, dosing, route, and duration of effects are however u…
View article: Comparative Effects of Bone Marrow-derived Versus Umbilical Cord Tissue Mesenchymal Stem Cells in an Experimental Model of Bronchopulmonary Dysplasia
Comparative Effects of Bone Marrow-derived Versus Umbilical Cord Tissue Mesenchymal Stem Cells in an Experimental Model of Bronchopulmonary Dysplasia Open
Bronchopulmonary dysplasia (BPD) is a life-threatening condition in preterm infants with few effective therapies. Mesenchymal stem or stromal cells (MSCs) are a promising therapeutic strategy for BPD. The ideal MSC source for BPD preventio…
View article: Circulating extracellular vesicles activate the pyroptosis pathway in the brain following ventilation-induced lung injury
Circulating extracellular vesicles activate the pyroptosis pathway in the brain following ventilation-induced lung injury Open
Background Mechanical ventilation of preterm newborns causes lung injury and is associated with poor neurodevelopmental outcomes. However, the mechanistic links between ventilation-induced lung injury (VILI) and brain injury is not well de…
View article: Author Correction: Hyperoxia-activated circulating extracellular vesicles induce lung and brain injury in neonatal rats
Author Correction: Hyperoxia-activated circulating extracellular vesicles induce lung and brain injury in neonatal rats Open
View article: Hyperoxia-activated circulating extracellular vesicles induce lung and brain injury in neonatal rats
Hyperoxia-activated circulating extracellular vesicles induce lung and brain injury in neonatal rats Open
View article: Long-term consequences of prematurity
Long-term consequences of prematurity Open
Due to a shortened period of in utero organ development, premature infants are at higher risk of chronic respiratory, cardiac, renal, and endocrine system disorders later in life. With more premature babies being born and more of them surv…
View article: Soluble Klotho, a biomarker and therapeutic strategy to reduce bronchopulmonary dysplasia and pulmonary hypertension in preterm infants
Soluble Klotho, a biomarker and therapeutic strategy to reduce bronchopulmonary dysplasia and pulmonary hypertension in preterm infants Open
Preterm infants with bronchopulmonary dysplasia (BPD) and pulmonary hypertension (PH) have accelerated lung aging and poor long-term outcomes. Klotho is an antiaging protein that modulates oxidative stress, angiogenesis and fibrosis. Here …
View article: Effects of Klotho supplementation on hyperoxia-induced renal injury in a rodent model of postnatal nephrogenesis
Effects of Klotho supplementation on hyperoxia-induced renal injury in a rodent model of postnatal nephrogenesis Open
View article: Neonatal hyperoxia exposure induces aortic biomechanical alterations and cardiac dysfunction in juvenile rats
Neonatal hyperoxia exposure induces aortic biomechanical alterations and cardiac dysfunction in juvenile rats Open
Supplemental oxygen (O2 ) therapy in preterm infants impairs lung development, but the impact of O2 on long-term systemic vascular structure and function has not been well-explored. The present study tested the hypoth…
View article: Intra-tracheal administration of a naked plasmid expressing stromal derived factor-1 improves lung structure in rodents with experimental bronchopulmonary dysplasia
Intra-tracheal administration of a naked plasmid expressing stromal derived factor-1 improves lung structure in rodents with experimental bronchopulmonary dysplasia Open
View article: TNFα-stimulated protein 6 (TSG-6) reduces lung inflammation in an experimental model of bronchopulmonary dysplasia
TNFα-stimulated protein 6 (TSG-6) reduces lung inflammation in an experimental model of bronchopulmonary dysplasia Open
View article: Riociguat prevents hyperoxia-induced lung injury and pulmonary hypertension in neonatal rats without effects on long bone growth
Riociguat prevents hyperoxia-induced lung injury and pulmonary hypertension in neonatal rats without effects on long bone growth Open
Bronchopulmonary dysplasia (BPD) remains the most common and serious chronic lung disease of premature infants. Severe BPD complicated with pulmonary hypertension (PH) increases the mortality of these infants. Riociguat is an allosteric so…
View article: 50 Years Ago in The Journal of Pediatrics
50 Years Ago in The Journal of Pediatrics Open