Birgit Mertens
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View article: Variability and uncertainty of data from genotoxicity Test Guidelines: What we know and why it matters.
Variability and uncertainty of data from genotoxicity Test Guidelines: What we know and why it matters. Open
This review comprehensively examines the variability and uncertainty associated with TG conform genotoxicity data and explores the respective implications for the integration of non-animal methods (NAMs) into regulatory frameworks. Histori…
View article: Genetic and epigenetic biomarkers in human biomonitoring: why needed and how can Oxford Nanopore sequencing contribute?
Genetic and epigenetic biomarkers in human biomonitoring: why needed and how can Oxford Nanopore sequencing contribute? Open
Chemical risk assessment can benefit from integrating informative biomarkers in human biomonitoring (HBM). Beyond exposure biomarkers, effect biomarkers inform on biological reactions in the body, potentially leading to adverse effects, wh…
View article: Hazard characterization of the mycotoxins enniatins and beauvericin to identify data gaps and improve risk assessment for human health
Hazard characterization of the mycotoxins enniatins and beauvericin to identify data gaps and improve risk assessment for human health Open
View article: Validation of an LC-MS Method for Quantification of Mycotoxins and Characterization of Fungal Strains Occurring in Food and Feed
Validation of an LC-MS Method for Quantification of Mycotoxins and Characterization of Fungal Strains Occurring in Food and Feed Open
Mycotoxins are naturally occurring secondary metabolites produced by specific fungal strains. They can cause adverse effects, posing a serious health threat to both humans and livestock. Focusing on several mycotoxins, this study first aim…
View article: A benchmark concentration-based strategy for evaluating the combined effects of genotoxic compounds in TK6 cells
A benchmark concentration-based strategy for evaluating the combined effects of genotoxic compounds in TK6 cells Open
View article: A global AOP network for genotoxicity to drive the integration of NAMs
A global AOP network for genotoxicity to drive the integration of NAMs Open
View article: Review of New Approach Methodologies for Application in Risk Assessment of Nanoparticles in the Food and Feed Sector: Status and Challenges
Review of New Approach Methodologies for Application in Risk Assessment of Nanoparticles in the Food and Feed Sector: Status and Challenges Open
New Approach Methodologies (NAMs), broadly understood to include in silico, in chemico, in vitro and ex vivo methods, show great potential in advancing risk assessment albeit their regulatory implementation is lagging. The EFSA Guidance on…
View article: Proposal for a qualification system for New Approach Methodologies (NAMs) in the food and feed sector: example of implementation for nanomaterial risk assessment
Proposal for a qualification system for New Approach Methodologies (NAMs) in the food and feed sector: example of implementation for nanomaterial risk assessment Open
Plenty of new approach methodologies (NAMs) for risk assessment have been developed but only some are included in OECD Test Guidelines (TGs) for regulatory implementation. Nevertheless, NAMs are increasingly applied, e.g. for nanomaterial …
View article: Author Correction: Hazard characterization of Alternaria toxins to identify data gaps and improve risk assessment for human health
Author Correction: Hazard characterization of Alternaria toxins to identify data gaps and improve risk assessment for human health Open
Publisher Copyright: © The Author(s) 2024.
View article: Sphaeropsidin A C15–C16 Cross‐Metathesis Analogues with Potent Anticancer Activity
Sphaeropsidin A C15–C16 Cross‐Metathesis Analogues with Potent Anticancer Activity Open
We recently discovered that sphaeropsidin A (SphA), a fungal metabolite from Diplodia cupressi , overcomes apoptosis resistance in cancer cells by inducing cellular shrinkage by impairing regulatory volume increase. Previously, we prepared…
View article: Exposure assessment and cytogenetic biomonitoring study of workers occupationally exposed to extremely low‐frequency magnetic fields
Exposure assessment and cytogenetic biomonitoring study of workers occupationally exposed to extremely low‐frequency magnetic fields Open
Human cytogenetic biomonitoring (HCB) has long been used to evaluate the potential effects of work environments on the DNA integrity of workers. However, HCB studies on the genotoxic effects of occupational exposure to extremely low‐freque…
View article: Unlocking the Power of Transcriptomic Biomarkers in Qualitative and Quantitative Genotoxicity Assessment of Chemicals
Unlocking the Power of Transcriptomic Biomarkers in Qualitative and Quantitative Genotoxicity Assessment of Chemicals Open
To modernize genotoxicity assessment and reduce reliance on experimental animals, new approach methodologies (NAMs) that provide human-relevant dose-response data are needed. Two transcriptomic biomarkers, GENOMARK and TGx-DDI, have shown …
View article: A systematic review and meta-analysis of human population studies on the association between exposure to toxic environmental chemicals and left ventricular dysfunction (LVD)
A systematic review and meta-analysis of human population studies on the association between exposure to toxic environmental chemicals and left ventricular dysfunction (LVD) Open
Existing evidence shows that specific early markers of HF may be associated with exposure to chemical pollutants. It is recommended to include such endpoints in new longitudinal and case-control studies to confirm further risk associations…
View article: Hazard characterization of Alternaria toxins to identify data gaps and improve risk assessment for human health
Hazard characterization of Alternaria toxins to identify data gaps and improve risk assessment for human health Open
View article: Cardiotoxicity of Chemicals: Current Regulatory Guidelines, Knowledge Gaps, and Needs
Cardiotoxicity of Chemicals: Current Regulatory Guidelines, Knowledge Gaps, and Needs Open
In a recently published article, Daley et al. (2023) emphasized the need for a new approach to assess cardiotoxicity of environmental compounds, an issue that has been neglected to date. They described how efforts for the evaluation of car…
View article: Final Set of AOPs and/or AOP network for cardiotoxicity
Final Set of AOPs and/or AOP network for cardiotoxicity Open
The aim of this deliverable is to provide a set of putative adverse outcome pathways (AOPs) and/or AOP network(s) (AONs) for cardiotoxicity. The deliverable contains: 1) an AON leading to electrophysiological effects, 2) an AON leading to …
View article: Effects of long-term exposure to 50 Hz magnetic fields on cell viability, genetic damage, and sensitivity to mutagen-induced damage
Effects of long-term exposure to 50 Hz magnetic fields on cell viability, genetic damage, and sensitivity to mutagen-induced damage Open
View article: Pollutant exposure and myocardial injury: Protocol and progress report for a toxicological systematic mapping review
Pollutant exposure and myocardial injury: Protocol and progress report for a toxicological systematic mapping review Open
An increasing body of evidence identifies pollutant exposure as a risk factor for cardiovascular disease (CVD), while CVD incidence is rising steadily with the aging population. Although numerous experimental studies are now available, the…
View article: D8.1 Initial dissemination and communication plan
D8.1 Initial dissemination and communication plan Open
This report presents the plan of the ALTERNATIVE project for its dissemination and communication activities and related results over the whole project period of 36 months, with a special focus on the planning for the first 18 months.
View article: D2.1 Documentation of regulatory needs for cardiotoxicity methods and data
D2.1 Documentation of regulatory needs for cardiotoxicity methods and data Open
This document aims to provide an overview on the regulatory needs for cardiotoxicity methods and data that can be used for consultation of national and European Preliminary Assessment of REgulatory Relevance (PARERE) Networks. We provide a…
View article: RE-Place: A Unique Project Collecting Expertise on New Approach Methodologies
RE-Place: A Unique Project Collecting Expertise on New Approach Methodologies Open
By applying “New Approach Methodologies (NAMs)” based on innovative technologies such as computer modeling, high throughput testing, omics, and sophisticated cell cultures, the use of experimental animals in the life sciences can be reduce…
View article: Occurrence of (suspected) genotoxic flavoring substances in Belgian alcohol-free beers
Occurrence of (suspected) genotoxic flavoring substances in Belgian alcohol-free beers Open
View article: Mineral oil risk assessment: Knowledge gaps and roadmap. Outcome of a multi-stakeholders workshop
Mineral oil risk assessment: Knowledge gaps and roadmap. Outcome of a multi-stakeholders workshop Open
View article: Identification of flavouring substances of genotoxic concern present in e-cigarette refills
Identification of flavouring substances of genotoxic concern present in e-cigarette refills Open
View article: New QSAR models to predict chromosome damaging potential based on the in vivo micronucleus test
New QSAR models to predict chromosome damaging potential based on the in vivo micronucleus test Open
View article: <i>In Vitro</i> and <i>In Vivo</i> Toxicity Studies on<i> Cymbopogon giganteus </i>Chiov. Leaves Essential Oil from Benin
<i>In Vitro</i> and <i>In Vivo</i> Toxicity Studies on<i> Cymbopogon giganteus </i>Chiov. Leaves Essential Oil from Benin Open
Cymbopogon giganteus Chiov. (Poaceae) is a medicinal plant used to treat various diseases in traditional medicine in several African countries. The present study aims to evaluate the oral and inhalation toxicity as well as the mutagenic ef…
View article: RE-Place: A local initiative to pave the road towards international recognition and promotion of new approach methodologies
RE-Place: A local initiative to pave the road towards international recognition and promotion of new approach methodologies Open
View article: In vitro 50 Hz magnetic field long-term exposure: Cytogenetic tests on human lymphoblastoid TK6 cells and validation of the test environment
In vitro 50 Hz magnetic field long-term exposure: Cytogenetic tests on human lymphoblastoid TK6 cells and validation of the test environment Open
View article: RE-Place: Centralizing information on alternative methods to animal testing to promote knowledge sharing
RE-Place: Centralizing information on alternative methods to animal testing to promote knowledge sharing Open
Performance of In Silico Models for Mutagenicity Prediction of Food Contact Materials Open