Mervin Chávez-Castillo
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View article: Neuroprotective Role of Omega-3 Fatty Acids: Fighting Alzheimer’s Disease
Neuroprotective Role of Omega-3 Fatty Acids: Fighting Alzheimer’s Disease Open
Alzheimer’s disease (AD) is one of the main causes of dementia, with an exponential increment in its incidence as years go by. However, since pathophysiological mechanisms are complex and multifactorial, therapeutic strategies remain incon…
View article: Prevalence and risk factors of posttraumatic stress disorder in COVID-19
Prevalence and risk factors of posttraumatic stress disorder in COVID-19 Open
Posttraumatic stress disorder (PTSD) has a prevalence of 2%–5% in the general population. COVID-19 is regarded as a traumatic agent that can increase the prevalence of this disorder to up to 30%. A documentary review was thus conducted, wh…
View article: Electroconvulsive Therapy in Psychiatric Disorders: A Narrative Review Exploring Neuroendocrine–Immune Therapeutic Mechanisms and Clinical Implications
Electroconvulsive Therapy in Psychiatric Disorders: A Narrative Review Exploring Neuroendocrine–Immune Therapeutic Mechanisms and Clinical Implications Open
Electroconvulsive therapy (ECT) is based on conducting an electrical current through the brain to stimulate it and trigger generalized convulsion activity with therapeutic ends. Due to the efficient use of ECT during the last years, intere…
View article: Psycho-Neuro-Endocrine-Immunological Basis of the Placebo Effect: Potential Applications beyond Pain Therapy
Psycho-Neuro-Endocrine-Immunological Basis of the Placebo Effect: Potential Applications beyond Pain Therapy Open
The placebo effect can be defined as the improvement of symptoms in a patient after the administration of an innocuous substance in a context that induces expectations regarding its effects. During recent years, it has been discovered that…
View article: Psicosis puerperal: una patología olvidada
Psicosis puerperal: una patología olvidada Open
La psicosis puerperal (PP) es el trastorno más grave que se puede presentar durante el puerperio, con consecuencias en ocasiones fatales. Antecedentes de PP en embarazos anteriores o padecer de trastorno afectivo bipolar o esquizofrenia au…
View article: Specialized Pro-Resolving Lipid Mediators: The Future of Chronic Pain Therapy?
Specialized Pro-Resolving Lipid Mediators: The Future of Chronic Pain Therapy? Open
Chronic pain (CP) is a severe clinical entity with devastating physical and emotional consequences for patients, which can occur in a myriad of diseases. Often, conventional treatment approaches appear to be insufficient for its management…
View article: Metabolic Syndrome: Is It Time to Add the Central Nervous System?
Metabolic Syndrome: Is It Time to Add the Central Nervous System? Open
Metabolic syndrome (MS) is a set of cardio-metabolic risk factors that includes central obesity, hyperglycemia, hypertension, and dyslipidemias. The syndrome affects 25% of adults worldwide. The definition of MS has evolved over the last 8…
View article: Alzheimer’s disease and type 2 diabetes mellitus: Pathophysiologic and pharmacotherapeutics links
Alzheimer’s disease and type 2 diabetes mellitus: Pathophysiologic and pharmacotherapeutics links Open
At present, Alzheimer's disease (AD) and type 2 diabetes mellitus (T2DM) are two highly prevalent disorders worldwide, especially among elderly individuals. T2DM appears to be associated with cognitive dysfunction, with a higher risk of de…
View article: Late-onset type 1 diabetes mellitus or latent autoimmune diabetes in adults: a teachable moment
Late-onset type 1 diabetes mellitus or latent autoimmune diabetes in adults: a teachable moment Open
Adult-onset autoimmune diabetes (AOAD) is clinical form of diabetes with a wide spectrum of genotypical and phenotypical manifestations, which has risen in prominence in recent decades, probably due to greater interest in its pathogenic me…
View article: Depression as an Immunometabolic Disorder: Exploring Shared Pharmacotherapeutics with Cardiovascular Disease
Depression as an Immunometabolic Disorder: Exploring Shared Pharmacotherapeutics with Cardiovascular Disease Open
Modern times have seen depression and cardiovascular disease (CVD) become notorious public health concerns, corresponding to alarming proportions of morbidity, mortality, decreased quality of life, and economic costs. Expanding comprehensi…
View article: A Stratified Approach for Cushing’s Syndrome Diagnosis
A Stratified Approach for Cushing’s Syndrome Diagnosis Open
Cushing’s syndrome is an endocrine disorder broadly renowned as a diagnostic challenge. From the initial clinical presentation up to the identification of the underlying etiology, it is necessary to adhere to a logical and stratified…
View article: Depression as a Neuroendocrine Disorder: Emerging Neuropsychopharmacological Approaches beyond Monoamines
Depression as a Neuroendocrine Disorder: Emerging Neuropsychopharmacological Approaches beyond Monoamines Open
Depression is currently recognized as a crucial problem in everyday clinical practice, in light of ever-increasing rates of prevalence, as well as disability, morbidity, and mortality related to this disorder. Currently available antidepre…
View article: Correction: Energetic metabolism in cardiomyocytes: molecular basis of heart ischemia and arrhythmogenesis
Correction: Energetic metabolism in cardiomyocytes: molecular basis of heart ischemia and arrhythmogenesis Open
Vessel Plus is an open acccess journal, which publishes articles related to vascular diseases, including acute respiratory distress syndrome, aneurysm, atherosclerosis, hypertension, stroke, peripheral vascular or pulmonary vascular diseas…
View article: DEPRESIÓN Y OBESIDAD: UNA RELACIÓN BIDIRECCIONAL
DEPRESIÓN Y OBESIDAD: UNA RELACIÓN BIDIRECCIONAL Open
View article: El consumo de fibra dietética está inversamente asociado con el estado nutricional antropométrico y con los componentes del Síndrome Metabólico en niños y adolescentes
El consumo de fibra dietética está inversamente asociado con el estado nutricional antropométrico y con los componentes del Síndrome Metabólico en niños y adolescentes Open
Objetivo. Investigar la posible asociación entre el consumo
\nde fibra y el estado nutricional antropométrico en niños
\ny adolescentes, así como con la presencia de síndrome
\nmetabólico (SM) y sus componentes individuales.
\nMateriales y…
View article: Metabolic risk in depression and treatment with selective serotonin reuptake inhibitors: are the metabolic syndrome and an increase in cardiovascular risk unavoidable?
Metabolic risk in depression and treatment with selective serotonin reuptake inhibitors: are the metabolic syndrome and an increase in cardiovascular risk unavoidable? Open
Vessel Plus is an open acccess journal, which publishes articles related to vascular diseases, including acute respiratory distress syndrome, aneurysm, atherosclerosis, hypertension, stroke, peripheral vascular or pulmonary vascular diseas…
View article: Efecto del consumo de alimentos preparados en el hogar y adquiridos en la escuela sobre el perfil lipídico de escolares en Maracaibo, Venezuela
Efecto del consumo de alimentos preparados en el hogar y adquiridos en la escuela sobre el perfil lipídico de escolares en Maracaibo, Venezuela Open
"Propósito: En décadas recientes, ha aumentado en la población infantil la prevalencia de enfermedades como obesidad y dislipidemias, de manera atribuible a prácticas propias de la sociedad occidentalizada. Esto incluye sobreingesta calóri…
View article: Energetic metabolism in cardiomyocytes: molecular basis of heart ischemia and arrhythmogenesis
Energetic metabolism in cardiomyocytes: molecular basis of heart ischemia and arrhythmogenesis Open
Vessel Plus is an open acccess journal, which publishes articles related to vascular diseases, including acute respiratory distress syndrome, aneurysm, atherosclerosis, hypertension, stroke, peripheral vascular or pulmonary vascular diseas…
View article: Dysglycemic states and hypertension: A relationship dependent on low-grade inflammation
Dysglycemic states and hypertension: A relationship dependent on low-grade inflammation Open
Background: Hypertension (HTN) is a prominent cardiovascular risk factor, affecting over 1 billion people worldwide. Identification of closely associated cardiometabolic conditions may be crucial for its early detection. The objective of t…
View article: Optimal cutoff for visceral adiposity index in a Venezuelan population: Results from the Maracaibo City Metabolic Syndrome Prevalence Study
Optimal cutoff for visceral adiposity index in a Venezuelan population: Results from the Maracaibo City Metabolic Syndrome Prevalence Study Open
Visceral obesity is one of the most intensely researched cardiometabolic risk factors in recent years; nonetheless, its accurate assessment remains a challenge in regions were socioeconomic conditions hinder the widespread use of diagnosti…
View article: Omega-3 polyunsaturated fatty acids and cardiovascular health: a molecular view into structure and function
Omega-3 polyunsaturated fatty acids and cardiovascular health: a molecular view into structure and function Open
Vessel Plus is an open acccess journal, which publishes articles related to vascular diseases, including acute respiratory distress syndrome, aneurysm, atherosclerosis, hypertension, stroke, peripheral vascular or pulmonary vascular diseas…
View article: En busqueda del hipnótico ideal: tratamiento farmacológico del insomnio
En busqueda del hipnótico ideal: tratamiento farmacológico del insomnio Open
El insomnio es un trastorno del sueño caracterizado por dificultad
\npara la conciliación o mantenimiento del sueño, por
\ndisminución del tiempo, fragmentación o mala calidad del
\nsueño, y sensación de cansancio al día siguiente. Se trat…
View article: Management and Education in Patients with Diabetes Mellitus
Management and Education in Patients with Diabetes Mellitus Open
Patients with Diabetes Mellitus (DM) can actively participate in the management of this disease, with therapeutic education playing an essential role in the optimization of knowledge, resources and skills required to achieve targets of met…
View article: Excitotoxicity: An Organized Crime at The Cellular Level
Excitotoxicity: An Organized Crime at The Cellular Level Open
Excitotoxicity is a form of neuronal death induced by increased Glutamate (Glu) signaling which has been implicated in the pathophysiology of a myriad of neuropsychiatric conditions, such as dementia, motor disorders and epilepsy, among ma…
View article: Hormona paratiroidea, aldosterona e hipertensión arterial ¿una amenaza infravalorada?
Hormona paratiroidea, aldosterona e hipertensión arterial ¿una amenaza infravalorada? Open
El Hiperparatiroidismo primario (HPTP) es un
\ntrastorno endocrino frecuente caracterizado
\npor una secreción autónoma de hormona
\nparatiroidea (PTH). Si bien, su variante asintomática es la
\nmás frecuentemente encontrada en la práctica…
View article: Raw data for the 2231 patient sample used in this study.
Raw data for the 2231 patient sample used in this study. Open
View article: Anthropometric Predictors for Multiple Risk Factor Aggregation in Adults from Maracaibo City
Anthropometric Predictors for Multiple Risk Factor Aggregation in Adults from Maracaibo City Open
Anthropometric parameters such as weight, length, skinfolds, perimeters and body diameters, are widely used in the medical field for clinical nutrition assessment, with the aim of assessing the growth, development, and determination of the…
View article: Prevalence and Associated Factors of Insulin Resistance in Adults from Maracaibo City, Venezuela
Prevalence and Associated Factors of Insulin Resistance in Adults from Maracaibo City, Venezuela Open
Background and Aim . Insulin resistance (IR) is a prominent pathophysiologic component in a myriad of metabolic disorders, including obesity, prediabetes, and type 2 diabetes mellitus, which are common in our locality. The objective of thi…
View article: Dysfunctional High-Density Lipoprotein: An Innovative Target for Proteomics and Lipidomics
Dysfunctional High-Density Lipoprotein: An Innovative Target for Proteomics and Lipidomics Open
High-Density Lipoprotein-Cholesterol (HDL-C) is regarded as an important protective factor against cardiovascular disease, with abundant evidence of an inverse relationship between its serum levels and risk of cardiovascular disease, as we…
View article: Glucococorticoid-Induced Death of Pancreatic Beta Cells: An Organized Chaos
Glucococorticoid-Induced Death of Pancreatic Beta Cells: An Organized Chaos Open
Glucocorticoids (GC) are renowned for their pleiotropic effects in all organ systems, their ubiquitous use in numerous clinical settings, and the abundant adverse effects they may exert, particularly in the endocrine-metabolic sphere. Alth…