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View article: Integrative immune subtyping of HNSCC reveals clinically relevant phenotypes and treatment-associated transitions
Integrative immune subtyping of HNSCC reveals clinically relevant phenotypes and treatment-associated transitions Open
Head and neck squamous cell carcinoma (HNSCC) exhibits profound heterogeneity in clinical presentation, treatment response, and immune landscape. While prior classification systems have identified molecular and immune subtypes in this dise…
View article: Dose Selection for <scp>DuoBody</scp>®‐<scp>CD40x4</scp>‐<scp>1BB</scp> (<scp>GEN1042</scp>/<scp>BNT312</scp>) Using a <scp>mPBPK</scp>/<scp>RO</scp> Model Leveraging Preclinical and Clinical Data
Dose Selection for <span>DuoBody</span>®‐<span>CD40x4</span>‐<span>1BB</span> (<span>GEN1042</span>/<span>BNT312</span>) Using a <span>mPBPK</span>/<span>RO</span> Model Leveraging Preclinical and Clinical Data Open
Optimizing target engagement for bispecific antibodies (bsAbs) is challenging, as bsAbs bind to two different targets in vivo to form a trimolecular complex (trimer), and likely display a bell‐shaped concentration–response curve. bsAbs tri…
View article: 655 Acasunlimab in combination with pembrolizumab reinvigorates anti-tumor immunity in patients with previously treated metastatic non-small cell lung cancer (NSCLC)
655 Acasunlimab in combination with pembrolizumab reinvigorates anti-tumor immunity in patients with previously treated metastatic non-small cell lung cancer (NSCLC) Open
View article: 153 High expression of tertiary lymphoid structure gene signatures is associated with improved survival in head and neck squamous cell carcinoma patients treated with immune checkpoint blockade
153 High expression of tertiary lymphoid structure gene signatures is associated with improved survival in head and neck squamous cell carcinoma patients treated with immune checkpoint blockade Open
Background The presence of tertiary lymphoid structures (TLS) has been associated with improved response to immune checkpoint blockade (ICB) treatment in several indications including non-small cell lung and bladder cancers, sarcomas, and …
View article: 1288 Characterization of tertiary lymphoid structure in pancreatic ductal adenocarcinoma tumors: insights from gene expression and pathology images, and identification using a deep learning approach
1288 Characterization of tertiary lymphoid structure in pancreatic ductal adenocarcinoma tumors: insights from gene expression and pathology images, and identification using a deep learning approach Open
Background Tertiary lymphoid structure (TLS) is an organized cluster of immune cells in nonlymphoid tissues that have prognostic potential in patients treated with immunotherapies. Manual TLS annotation is error-prone and labor-intensive d…
View article: Deep computational image analysis of immune cell niches reveals treatment-specific outcome associations in lung cancer
Deep computational image analysis of immune cell niches reveals treatment-specific outcome associations in lung cancer Open
View article: Image analysis reveals molecularly distinct patterns of TILs in NSCLC associated with treatment outcome
Image analysis reveals molecularly distinct patterns of TILs in NSCLC associated with treatment outcome Open