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View article: Effect of Intravenous Immunoglobulin (IVIG) Supplementation on infection-free survival in recipients of BCMA-directed bispecific antibody therapy for multiple myeloma
Effect of Intravenous Immunoglobulin (IVIG) Supplementation on infection-free survival in recipients of BCMA-directed bispecific antibody therapy for multiple myeloma Open
The main objective of this multi-institutional study is to understand the effect of primary intravenous immunoglobulin (IVIG) replacement on clinical outcomes in recipients of BCMA-directed bispecific antibody (bsAb), where infection remai…
View article: Proteinuria with Preserved Renal Function: A Retrospective Cohort Study of Myeloma Patients with Significant Proteinuria without Acute Kidney Injury
Proteinuria with Preserved Renal Function: A Retrospective Cohort Study of Myeloma Patients with Significant Proteinuria without Acute Kidney Injury Open
INTRODUCTION Myeloma cast nephropathy (MCN), in which patients present with renal dysfunction and Bence-Jones proteinuria, is a well-described negative prognostic marker in newly diagnosed multiple myeloma (NDMM). Some patients with NDMM p…
View article: Efficacy and Safety of Teclistamab in Relapsed Refractory Multiple Myeloma: Long-Term Follow-up from a Real World Multi-Institutional Cohort
Efficacy and Safety of Teclistamab in Relapsed Refractory Multiple Myeloma: Long-Term Follow-up from a Real World Multi-Institutional Cohort Open
Introduction: Teclistamab is a B cell maturation antigen (BCMA)-targeting bispecific antibody (bsAb) that is approved in patients with relapsed/refractory multiple myeloma (RRMM) who have received at least four prior lines of therapy. In t…
View article: Effects of Intravenous Immunoglobulin Supplementation (IVIG) on Infections in Recipients of Teclistamab Therapy for Multiple Myeloma (MM): A Multi-Institutional Study
Effects of Intravenous Immunoglobulin Supplementation (IVIG) on Infections in Recipients of Teclistamab Therapy for Multiple Myeloma (MM): A Multi-Institutional Study Open
Introduction: While IVIG supplementation has been shown to prevent high-grade infectious complications, there is lack of clear consensus on the optimal timing of initiation of IVIG in the context of teclistamab for MM. In this multi-instit…
View article: Disrupting the DREAM complex enables proliferation of adult human pancreatic β cells
Disrupting the DREAM complex enables proliferation of adult human pancreatic β cells Open
Resistance to regeneration of insulin-producing pancreatic β cells is a fundamental challenge for type 1 and type 2 diabetes. Recently, small molecule inhibitors of the kinase DYRK1A have proven effective in inducing adult human β cells to…
View article: Conservation of cell-intrinsic immune responses in diverse nonhuman primate species
Conservation of cell-intrinsic immune responses in diverse nonhuman primate species Open
Differences in immune responses across species can contribute to the varying permissivity of species to the same viral pathogen. Understanding how our closest evolutionary relatives, nonhuman primates (NHPs), confront pathogens and how the…
View article: Differences across cyclophilin A orthologs contribute to the host range restriction of hepatitis C virus
Differences across cyclophilin A orthologs contribute to the host range restriction of hepatitis C virus Open
The restricted host tropism of hepatitis C virus (HCV) remains incompletely understood, especially post-entry, and has hindered developing an immunocompetent, small animal model. HCV replication in non-permissive species may be limited by …
View article: Author response: Differences across cyclophilin A orthologs contribute to the host range restriction of hepatitis C virus
Author response: Differences across cyclophilin A orthologs contribute to the host range restriction of hepatitis C virus Open
Article Figures and data Abstract eLife digest Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract The restricted host tropism o…
View article: Species-specific disruption of STING-dependent antiviral cellular defenses by the Zika virus NS2B3 protease
Species-specific disruption of STING-dependent antiviral cellular defenses by the Zika virus NS2B3 protease Open
Significance To shed light on the host range of Zika virus (ZIKV), we surveyed the virus’ ability to infect cells of evolutionarily diverse species. ZIKV replicates efficiently in human, great ape, Old and New World monkey, but not rodent …