Mette Reilev
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View article: Time Windows Used when Identifying Current Drug Use and Polypharmacy
Time Windows Used when Identifying Current Drug Use and Polypharmacy Open
Background There is no consensus on the definition of the prevalence of drug use, including polypharmacy, regarding the length of the time window and the number of required concomitant medications. Objectives We aim to explore how the esti…
View article: Incidence of suicide and suicide attempts following a diagnosis of cancer: A nationwide study using Danish registry data
Incidence of suicide and suicide attempts following a diagnosis of cancer: A nationwide study using Danish registry data Open
Suicidal behavior significantly increased around the time of cancer diagnosis, highlighting critical periods for intervention. These findings emphasize the importance of integrated mental health support for cancer patients, particularly in…
View article: Homeless shelter contacts and suicide risk: a critical window for intervention
Homeless shelter contacts and suicide risk: a critical window for intervention Open
View article: Characteristics and care trajectories of older patients in temporary stays in Denmark
Characteristics and care trajectories of older patients in temporary stays in Denmark Open
View article: Medication use patterns among older patients in temporary stays in Denmark
Medication use patterns among older patients in temporary stays in Denmark Open
Purpose Patients in temporary stays are typically older individuals with frailty and multimorbidity. However, limited knowledge exists about their medication use. This study aimed to describe prescription drug use among patients in tempora…
View article: Initiation and Discontinuation of Psychotropic Drugs Relative to Suicidal Behavior: A Danish Registry‐Based Study
Initiation and Discontinuation of Psychotropic Drugs Relative to Suicidal Behavior: A Danish Registry‐Based Study Open
Introduction Changes in psychotropic drug use relative to suicidal behavior could potentially inform the timing of preventive efforts. We aimed to describe the initiation and discontinuation of psychotropic drugs relative to suicide and su…
View article: Contact patterns in health care before and after first registered suicide attempt or self-harm: A nationwide register study
Contact patterns in health care before and after first registered suicide attempt or self-harm: A nationwide register study Open
This study aimed to identify possible missed opportunities for suicide prevention by investigating health care utilization two years before and after the first recorded suicide attempt or self-harm (SA/SH). The SA/SH group was identified i…
View article: Burden of psychiatric and somatic comorbidities in individuals with suicidal behavior: a nationwide Danish registry-based, observational study
Burden of psychiatric and somatic comorbidities in individuals with suicidal behavior: a nationwide Danish registry-based, observational study Open
Background Many psychiatric and somatic comorbidities increase the risk of suicidal behavior, but the effect of co-existing comorbidities is sparsely elucidated. We described co-existence of psychiatric and somatic comorbidities and the in…
View article: Biologics Used for Psoriasis: A Drug Utilization Study Based on Two Nationwide Danish Data Sources
Biologics Used for Psoriasis: A Drug Utilization Study Based on Two Nationwide Danish Data Sources Open
Purpose Biological treatment has been a game changer in the management of moderate‐to‐severe psoriasis. In Denmark, biological treatment for psoriasis is registered in two data sources. We aimed to describe the utilization of biologics for…
View article: Characteristics and care trajectories of older patients in temporary stays in Denmark
Characteristics and care trajectories of older patients in temporary stays in Denmark Open
Background Temporary stays for patients requiring short-term care outside the home, often following hospital discharge, has gained increasing importance. This study aimed to describe the characteristics and care trajectories of older patie…
View article: Medication use patterns among older patients in temporary stays in Denmark
Medication use patterns among older patients in temporary stays in Denmark Open
Background Patients in temporary stays are typically older individuals with frailty and multimorbidity. However, limited knowledge exists about their medication use. This study aimed to describe prescription drug use among patients in temp…
View article: The joint effect of mental illness and parental suicide attempt on offspring suicide attempt and death: A Danish nationwide, registry-based study using multistate modeling
The joint effect of mental illness and parental suicide attempt on offspring suicide attempt and death: A Danish nationwide, registry-based study using multistate modeling Open
Exposure to both parental suicide attempt and own mental illness increases the relative and absolute risks of suicide attempt and premature death with considerable differences across sex. These findings are important in the clinical assess…
View article: Comparative Analysis of Outpatient Antibiotic Prescribing in Early Life: A Population-Based Study Across Birth Cohorts in Denmark and Germany
Comparative Analysis of Outpatient Antibiotic Prescribing in Early Life: A Population-Based Study Across Birth Cohorts in Denmark and Germany Open
Infants in Denmark received antibiotics markedly earlier and more frequently than in Germany, while quality indicators of antibiotic prescribing were more favorable in Denmark. Although both countries experienced positive changes towards m…
View article: Use of molnupiravir: A Danish nationwide drug utilization study
Use of molnupiravir: A Danish nationwide drug utilization study Open
Purpose To describe utilization patterns, characteristics of users and prescribers of the new oral antiviral medication, molnupiravir, indicated for mild‐to‐moderate COVID‐19. Methods Using nationwide registries, we identified all Danish a…
View article: Use of molnupiravir: a Danish nationwide drug utilization study
Use of molnupiravir: a Danish nationwide drug utilization study Open
Purpose To describe utilization patterns, characteristics of users and prescriber responsibility of the new oral antiviral medication, molnupiravir, indicated for mild-to-moderate COVID-19. Methods Using nationwide registries, we identifie…
View article: Methodology of the brodalumab assessment of hazards: a multicentre observational safety (BRAHMS) study
Methodology of the brodalumab assessment of hazards: a multicentre observational safety (BRAHMS) study Open
Introduction Safe and effective pharmacological treatment is of paramount importance for treating severe psoriasis. Brodalumab, a monoclonal antibody against interleukin (IL) 17 receptor A, was granted marketing authorisation in the EU in …
View article: Development and Validation of a Nordic Multimorbidity Index Based on Hospital Diagnoses and Filled Prescriptions
Development and Validation of a Nordic Multimorbidity Index Based on Hospital Diagnoses and Filled Prescriptions Open
The NMI predicted 5-year mortality in a general Danish population and six cohorts of new users of selected drugs and was superior to the CCI and ECI. The NMI could be preferred over these indices to quantify the level of multimorbidity for…
View article: Changing characteristics over time of individuals receiving COVID-19 vaccines in Denmark: A population-based descriptive study of vaccine uptake
Changing characteristics over time of individuals receiving COVID-19 vaccines in Denmark: A population-based descriptive study of vaccine uptake Open
Aims The Danish authorities implemented a differential rollout of the COVID-19 vaccines where individuals at high risk of COVID-19 were prioritized. We describe the temporal uptake of COVID-19 vaccines and changing characteristics of vacci…
View article: High‐dose non‐sedating antihistamines are used insufficiently in chronic urticaria patients treated with omalizumab
High‐dose non‐sedating antihistamines are used insufficiently in chronic urticaria patients treated with omalizumab Open
Background The lifetime prevalence of chronic urticaria (CU) is 0.5%–1%. In some patients with CU, symptomatic control is not achieved with non‐sedating second‐generation H1 antihistamines (nsAH1) alone, even with quadrupled standard doses…
View article: SARS-CoV-2 infection and adverse outcomes in users of ACE inhibitors and angiotensin-receptor blockers: a nationwide case-control and cohort analysis
SARS-CoV-2 infection and adverse outcomes in users of ACE inhibitors and angiotensin-receptor blockers: a nationwide case-control and cohort analysis Open
Objective To examine the impact of ACE inhibitor (ACE-I)/angiotensin receptor blocker (ARB) use on rate of SARS-CoV-2 infection and adverse outcomes. Methods This nationwide case-control and cohort study included all individuals in Denmark…
View article: Development of a Nordic frailty index based on hospital contacts and prescribed medications
Development of a Nordic frailty index based on hospital contacts and prescribed medications Open
View article: Renin–Angiotensin System Blockers and Adverse Outcomes of Influenza and Pneumonia: A Danish Cohort Study
Renin–Angiotensin System Blockers and Adverse Outcomes of Influenza and Pneumonia: A Danish Cohort Study Open
Background Angiotensin‐converting enzyme inhibitors (ACE‐Is) and angiotensin receptor blockers (ARBs) may worsen the prognosis of coronavirus disease 2019, but any association could be confounded by the cardiometabolic conditions indicatin…
View article: Adverse outcomes and mortality in users of non-steroidal anti-inflammatory drugs who tested positive for SARS-CoV-2: A Danish nationwide cohort study
Adverse outcomes and mortality in users of non-steroidal anti-inflammatory drugs who tested positive for SARS-CoV-2: A Danish nationwide cohort study Open
The European Union electronic Register of Post-Authorisation Studies EUPAS34734.
View article: Existing Data Sources in Clinical Epidemiology: The Danish COVID-19 Cohort
Existing Data Sources in Clinical Epidemiology: The Danish COVID-19 Cohort Open
Anton Pottegård,1 Kasper Bruun Kristensen,1 Mette Reilev,1 Lars Christian Lund,1 Martin Thomsen Ernst,1 Jesper Hallas,1,2 Reimar Wernich Thomsen,3 Christian Fynbo Christiansen,3 Henrik Toft Sørensen,3,4 Nanna Borup Johansen,5 Henrik Støvri…
View article: <p>Existing Data Sources in Clinical Epidemiology: The Danish COVID-19 Cohort</p>
Existing Data Sources in Clinical Epidemiology: The Danish COVID-19 Cohort Open
The Danish COVID-19 cohort includes all Danish residents with an RT-PCR test for SARS-CoV-2. Through individual-level linkage with existing Danish health and administrative registries, this is a valuable data source for epidemiological res…
View article: Characteristics and predictors of hospitalization and death in the first 11 122 cases with a positive RT-PCR test for SARS-CoV-2 in Denmark: a nationwide cohort
Characteristics and predictors of hospitalization and death in the first 11 122 cases with a positive RT-PCR test for SARS-CoV-2 in Denmark: a nationwide cohort Open
Background Population-level knowledge on individuals at high risk of severe and fatal coronavirus disease 2019 (COVID-19) is urgently needed to inform targeted protection strategies in the general population. Methods We examined characteri…
View article: Association of Nonsteroidal Anti-inflammatory Drug Use and Adverse Outcomes Among Patients Hospitalized With Influenza
Association of Nonsteroidal Anti-inflammatory Drug Use and Adverse Outcomes Among Patients Hospitalized With Influenza Open
In this cohort study of adult patients hospitalized with influenza, the use of NSAIDs was not associated with 30-day intensive care unit admission or death in adjusted analyses. There was an association between long-term use of NSAIDs and …
View article: Adverse Outcomes and Mortality in Users of Non-Steroidal Anti-Inflammatory Drugs tested positive for SARS-CoV-2: A Danish Nationwide Cohort Study
Adverse Outcomes and Mortality in Users of Non-Steroidal Anti-Inflammatory Drugs tested positive for SARS-CoV-2: A Danish Nationwide Cohort Study Open
Background Concerns over the safety of non-steroidal anti-inflammatory drug (NSAID) use during SARS-CoV-2 infection have been raised. Objectives To study whether use of NSAIDs is associated with adverse outcomes and mortality during SARS-C…
View article: Characteristics and predictors of hospitalization and death in the first 9,519 cases with a positive RT-PCR test for SARS-CoV-2 in Denmark: A nationwide cohort
Characteristics and predictors of hospitalization and death in the first 9,519 cases with a positive RT-PCR test for SARS-CoV-2 in Denmark: A nationwide cohort Open
Objective To provide population-level knowledge on individuals at high risk of severe and fatal coronavirus disease 2019 (COVID-19) in order to inform targeted protection strategies in the general population and appropriate triage of hospi…
View article: Long‐term oral budesonide treatment and risk of osteoporotic fractures in patients with microscopic colitis
Long‐term oral budesonide treatment and risk of osteoporotic fractures in patients with microscopic colitis Open
Summary Background Due to a substantial first‐pass metabolism of oral budesonide, systemic bioavailability is low compared to other oral corticosteroids, thereby possibly avoiding adverse effects of systemic corticosteroid use. Aim To dete…