Mette Vestergård Pedersen
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View article: Lipopolysaccharide induced systemic inflammation and heart rate variability in a term newborn piglet model
Lipopolysaccharide induced systemic inflammation and heart rate variability in a term newborn piglet model Open
Background Early biomarkers are needed to improve diagnosis and support antibiotic stewardship in neonatal sepsis. Heart rate variability (HRV) is proposed as such a biomarker. However, there is a lack of studies in term newborns. Infusion…
View article: Hyperpolarized <sup>13</sup>C magnetic resonance imaging in neonatal hypoxic–ischemic encephalopathy: First investigations in a large animal model
Hyperpolarized <sup>13</sup>C magnetic resonance imaging in neonatal hypoxic–ischemic encephalopathy: First investigations in a large animal model Open
Early biomarkers of cerebral damage are essential for accurate prognosis, timely intervention, and evaluation of new treatment modalities in newborn infants with hypoxia and ischemia at birth. Hyperpolarized 13 C magnetic resonance imaging…
View article: Early changes in cerebral metabolism after perinatal hypoxia-ischemia: a study in normothermic and hypothermic piglets
Early changes in cerebral metabolism after perinatal hypoxia-ischemia: a study in normothermic and hypothermic piglets Open
Introduction Hypoxic ischemic encephalopathy (HIE) after a perinatal insult is a dynamic process that evolves over time. Therapeutic hypothermia (TH) is standard treatment for severe to moderate HIE. There is a lack of evidence on the temp…
View article: 9th Congress of the European Academy of Paediatric Societies
9th Congress of the European Academy of Paediatric Societies Open
SO008 / #1063Short Oral SessionShort Oral Session 02: ESPNIC - Outcomefollowing intensive careBACKGROUND AND AIMSA review of the literature revealed the need to explore the experiences and perceptions of parents and health care providers (…
View article: Alpha-adrenergic receptor activation after fetal hypoxia-ischaemia suppresses transient epileptiform activity and limits loss of oligodendrocytes and hippocampal neurons
Alpha-adrenergic receptor activation after fetal hypoxia-ischaemia suppresses transient epileptiform activity and limits loss of oligodendrocytes and hippocampal neurons Open
Exposure to hypoxic-ischaemia (HI) is consistently followed by a delayed fall in cerebral perfusion. In preterm fetal sheep this is associated with impaired cerebral oxygenation, consistent with mismatch between perfusion and metabolism. I…
View article: Neurological Outcome Following Newborn Encephalopathy With and Without Perinatal Infection: A Systematic Review
Neurological Outcome Following Newborn Encephalopathy With and Without Perinatal Infection: A Systematic Review Open
Background: Studies have suggested that neurological outcome may differ in newborns with encephalopathy with and without perinatal infection. We aimed to systematically review this association. Methods: We conducted this systematic review …
View article: Epinephrine Versus Placebo During Resuscitation After Neonatal Hypoxic Cardiac Arrest: The Effect on ROSC and Markers of CNS Outcome Investigated in a Piglet Model
Epinephrine Versus Placebo During Resuscitation After Neonatal Hypoxic Cardiac Arrest: The Effect on ROSC and Markers of CNS Outcome Investigated in a Piglet Model Open
Background: Epinephrine is an integral component of neonatal resuscitation guidelines, despite sparse evidence. The association between advanced cardiopulmonary resuscitation (CPR) and poor neurodevelopment is well known, and epinephrine m…
View article: No Added Neuroprotective Effect of Remote Ischemic Postconditioning and Therapeutic Hypothermia After Mild Hypoxia-Ischemia in a Piglet Model
No Added Neuroprotective Effect of Remote Ischemic Postconditioning and Therapeutic Hypothermia After Mild Hypoxia-Ischemia in a Piglet Model Open
Introduction: Hypoxic ischemic encephalopathy (HIE) is a major cause of death and disability in children worldwide. Apart from supportive care, the only established treatment for HIE is therapeutic hypothermia (TH). As TH is only partly ne…
View article: Consequence of insertion trauma – effect on early measurements when using intracerebral devices
Consequence of insertion trauma – effect on early measurements when using intracerebral devices Open
There are a variety of devices that quantify biological properties of cerebral tissue. Installing such device will cause a local insertion trauma, which will affect early measurements. Current literature proposes minimum one hour of observ…
View article: Long‐term cognition and behavior in children born at early term gestation: A systematic review
Long‐term cognition and behavior in children born at early term gestation: A systematic review Open
Introduction Recent recommendations characterize deliveries at 37 +0 weeks through 38 +6 weeks as early term. We aimed to review the literature systematically on long‐term cognition, school performance and behavior in children born early t…