Michael G. Fehlings
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View article: Protocol for the development of enhanced recovery after surgery (ERAS) recommendations for individuals undergoing surgery for degenerative cervical myelopathy
Protocol for the development of enhanced recovery after surgery (ERAS) recommendations for individuals undergoing surgery for degenerative cervical myelopathy Open
ERAS recommendations for DCM aim to reduce the incidence and severity of adverse events, optimize patient outcomes, improve the efficiency and quality of care, and patients' experience and satisfaction with care.
View article: Use of an Expert Panel for Symptomatic Patients With Grade I Degenerative Lumbar Spondylolisthesis: A Randomized Clinical Trial
Use of an Expert Panel for Symptomatic Patients With Grade I Degenerative Lumbar Spondylolisthesis: A Randomized Clinical Trial Open
BACKGROUND AND OBJECTIVES: The appropriate utilization of lumbar fusion when performing laminectomy for lumbar spondylolisthesis is uncertain. The objective was to determine whether the use of a surgical expert review panel recommending fu…
View article: Enhanced Recovery After Surgery (ERAS) in Spine Surgery: A Systematic Review and Meta-Analysis of Spinal Surgery Sub – Specialities, Interventions and Efficacy
Enhanced Recovery After Surgery (ERAS) in Spine Surgery: A Systematic Review and Meta-Analysis of Spinal Surgery Sub – Specialities, Interventions and Efficacy Open
Study Design Systematic Review. Objectives Enhanced Recovery After Surgery (ERAS) is a widely acknowledged approach for improving surgical outcomes. This review aims at analyzing the characteristics of study populations, interventions and …
View article: Association Between Nutritional Status and Survival in Patients Requiring Treatment for Spinal Metastases
Association Between Nutritional Status and Survival in Patients Requiring Treatment for Spinal Metastases Open
BACKGROUND AND OBJECTIVES: The Patient-Generated Subjective Global Assessment (PG-SGA) is a standardized tool for assessing malnutrition in patients with cancer. The primary aim of this study was to assess the impact of preoperative nutrit…
View article: Endothelial ephrin-B2 knockdown increases post-traumatic disruption of the blood-spinal cord barrier following spinal cord injury
Endothelial ephrin-B2 knockdown increases post-traumatic disruption of the blood-spinal cord barrier following spinal cord injury Open
View article: Assessing the diagnostic accuracy of symptoms and signs of degenerative cervical myelopathy: A prospective study
Assessing the diagnostic accuracy of symptoms and signs of degenerative cervical myelopathy: A prospective study Open
View article: AAV9-mediated KCC2 upregulation enhances functional recovery following cervical spinal cord injury
AAV9-mediated KCC2 upregulation enhances functional recovery following cervical spinal cord injury Open
Following traumatic cervical spinal cord injury (SCI), injury-induced functional changes within the perilesional forelimb circuits are an important cause of neurological dysfunction. K+/Cl- cotransporter 2 (KCC2) is a…
View article: Comparison of Anterior and Posterior Surgical Approaches for Cervical Ossification of the Posterior Longitudinal Ligament Stratified by Spinal Levels: A Systematic Review and Meta-Analysis
Comparison of Anterior and Posterior Surgical Approaches for Cervical Ossification of the Posterior Longitudinal Ligament Stratified by Spinal Levels: A Systematic Review and Meta-Analysis Open
LAMP significantly preserved cervical range of motion. LAMP and laminectomy with fusion reduced dysphagia but increased C5 palsy. The anterior approach improved alignment and function, but the mJOA score and recovery rate were not clinical…
View article: Disparities in NIH funding for acute traumatic and chronic nontraumatic spinal cord injury: a 10-year national analysis
Disparities in NIH funding for acute traumatic and chronic nontraumatic spinal cord injury: a 10-year national analysis Open
View article: Oligodendrogenic neural progenitors for treatment of chronic compressive cervical spinal cord injury
Oligodendrogenic neural progenitors for treatment of chronic compressive cervical spinal cord injury Open
Chronic compressive cervical spinal cord injury (cCSCI), a debilitating condition, lacks effective treatment options. Addressing this gap, our study introduces a novel rat model of cCSCI developed through spinal cord compression via synthe…
View article: Anterior vs. posterior approaches in the management of multilevel degenerative cervical myelopathy: a systematic review and meta-analysis
Anterior vs. posterior approaches in the management of multilevel degenerative cervical myelopathy: a systematic review and meta-analysis Open
Both surgical approaches yield comparable long-term outcomes, with anterior surgery demonstrating statistically significant early functional advantages, shorter LOS, and lower odds of C5 palsy. However, these advantages diminish over time,…
View article: Standards for Reporting of Diagnostic Accuracy involving Intraoperative Neurophysiological Monitoring
Standards for Reporting of Diagnostic Accuracy involving Intraoperative Neurophysiological Monitoring Open
Title Standards for Reporting of Diagnostic Accuracy using Intraoperative Neurophysiological Monitoring (STARD-IONM) Objective Intraoperative neurophysiological monitoring (IONM) plays a critical role in preserving functional integrity dur…
View article: The sodium-glutamate antagonist riluzole improves outcome after acute spinal cord injury: results from the RISCIS randomised controlled trial analysed using a global statistical analytic technique
The sodium-glutamate antagonist riluzole improves outcome after acute spinal cord injury: results from the RISCIS randomised controlled trial analysed using a global statistical analytic technique Open
No funding was received for the present work. The original clinical trial (NCT01597518) was funded by the AO Foundation, United States Department of Defense (DOD), and the Praxis Spinal Cord Institute.
View article: The role of the iron-chelating agent deferoxamine in spinal cord injury: a systematic review and meta-analysis of preclinical studies
The role of the iron-chelating agent deferoxamine in spinal cord injury: a systematic review and meta-analysis of preclinical studies Open
View article: Laminoplasty compared to laminectomy and fusion for degenerative cervical myelopathy: a cost-utility analysis
Laminoplasty compared to laminectomy and fusion for degenerative cervical myelopathy: a cost-utility analysis Open
Both LP and LF can be cost-effective for DCM. While the base-case favored LF, probabilistic sensitivity analysis revealed no clear cost-utility advantage with comparable NMBs. Economic considerations alone should not drive surgical decisio…
View article: AO Spine Clinical Practice Recommendations for the Surgical Management of Acute Traumatic Spinal Cord Injury: Contemporary Concepts
AO Spine Clinical Practice Recommendations for the Surgical Management of Acute Traumatic Spinal Cord Injury: Contemporary Concepts Open
Study Design Review of the literature with critical appraisal and clinical recommendations. Objective To highlight contemporary concepts relating to surgical care for acute traumatic spinal cord injury (SCI) based on recent evidence that m…
View article: The AO Spine Knowledge Forums: A Decade of Impactful Spine Research
The AO Spine Knowledge Forums: A Decade of Impactful Spine Research Open
The AO Spine Knowledge Forums are independent expert-driven global study groups dedicated to improving patient care by publishing evidence-based recommendations and conducting high-impact clinical studies. Five Knowledge Forums represent 6…
View article: Evaluation of Adverse Events and the Impact on Health-Related Outcomes in Patients Undergoing Surgery for Metastatic Spine Tumors: Analysis of the Metastatic Tumor Research and Outcomes Network (MTRON) Registry Dataset
Evaluation of Adverse Events and the Impact on Health-Related Outcomes in Patients Undergoing Surgery for Metastatic Spine Tumors: Analysis of the Metastatic Tumor Research and Outcomes Network (MTRON) Registry Dataset Open
Study Design This study is part of the AO Spine Metastatic Tumor Research and Outcomes Network [MTRON], an international multicenter prospective observational registry including patients with spinal metastases. Objectives This study aims t…
View article: Spinal cord injury in severely injured patients: results from the Swiss Trauma Registry
Spinal cord injury in severely injured patients: results from the Swiss Trauma Registry Open
View article: P.205 Pain has a significant impact on post-operative quality of life outcomes in patients requiring surgical intervention for degenerative cervical myelopathy
P.205 Pain has a significant impact on post-operative quality of life outcomes in patients requiring surgical intervention for degenerative cervical myelopathy Open
Background: Degenerative Cervical Myelopathy (DCM) is a progressive condition causing cervical spinal cord injury. Disease severity is commonly assessed using the modified Japanese Orthopedic Association (mJOA) score, yet clinical guidelin…
View article: A message from Spinal Cord’s Editor-in-Chief
A message from Spinal Cord’s Editor-in-Chief Open
View article: DLK1-expressing neural progenitor cells promote tissue repair and functional recovery after cervical spinal cord injury
DLK1-expressing neural progenitor cells promote tissue repair and functional recovery after cervical spinal cord injury Open
Spinal cord injury (SCI) elicits a hostile microenvironment characterized by inflammation, gliosis, and disrupted signaling pathways that collectively impede neural repair. Neural progenitor cells (NPCs) represent a promising regenerative …
View article: Role of Neck Pain in Defining Clinical Trajectories of Outcomes in Patients With Degenerative Cervical Myelopathy: Results of a Novel Machine Learning Algorithm
Role of Neck Pain in Defining Clinical Trajectories of Outcomes in Patients With Degenerative Cervical Myelopathy: Results of a Novel Machine Learning Algorithm Open
Study Design Retrospective analysis of prospective data. Objectives Neck pain represents a crucial factor underscoring a patient’s decision to receive surgical intervention for degenerative cervical myelopathy (DCM). However, postoperative…
View article: Monitoring morphometric drift in lifelong learning segmentation of the spinal cord.
Monitoring morphometric drift in lifelong learning segmentation of the spinal cord. Open
Morphometric measures derived from spinal cord segmentations can serve as diagnostic and prognostic biomarkers in neurological diseases and injuries affecting the spinal cord. For instance, the spinal cord cross-sectional area can be used …
View article: Impact of surgery and radiation on radicular pain and myotomic weakness in patients with metastatic spine disease
Impact of surgery and radiation on radicular pain and myotomic weakness in patients with metastatic spine disease Open
OBJECTIVE Surgery is typically indicated for mechanical pain in metastatic spine disease or severe neurological compromise, but how radicular pain responds to oncological treatment is not well described. The primary aim of this study was t…
View article: AO Spine Clinical Practice Recommendations for Diagnosis and Management of Degenerative Cervical Myelopathy: Evidence Based Decision Making - A Review of Cutting Edge Recent Literature Related to Degenerative Cervical Myelopathy
AO Spine Clinical Practice Recommendations for Diagnosis and Management of Degenerative Cervical Myelopathy: Evidence Based Decision Making - A Review of Cutting Edge Recent Literature Related to Degenerative Cervical Myelopathy Open
Study Design Literature review of key topics related to degenerative cervical myelopathy (DCM) with critical appraisal and clinical recommendations. Objective This article summarizes several key current topics related to the management of …
View article: Response to “Proclaim (Best Available) Truth From the Rooftops”: A Community Doc’s Alternate View on Dissemination& Implementation of AO Spine/Praxis’ 2024 Acute Spinal Cord Injury Guidelines
Response to “Proclaim (Best Available) Truth From the Rooftops”: A Community Doc’s Alternate View on Dissemination& Implementation of AO Spine/Praxis’ 2024 Acute Spinal Cord Injury Guidelines Open
View article: Advancing Metastatic Spine Tumor Research: A Review of AO Spine Knowledge Forum Tumor’s Scientific Contributions Derived From the EPOSO Network, 2014-2024
Advancing Metastatic Spine Tumor Research: A Review of AO Spine Knowledge Forum Tumor’s Scientific Contributions Derived From the EPOSO Network, 2014-2024 Open
Study Design Narrative Review. Objectives To summarize the work of the AO Spine Knowledge Forum Tumor, specifically studies from the Epidemiology, Process and Outcomes in Spine Oncology (EPOSO) study. Methods A narrative review of all publ…
View article: Influence of Frailty on Clinical and Radiological Outcomes in Patients Undergoing Transforaminal Lumbar Interbody Fusion—Analysis of a Controlled Cohort of 408 Patients
Influence of Frailty on Clinical and Radiological Outcomes in Patients Undergoing Transforaminal Lumbar Interbody Fusion—Analysis of a Controlled Cohort of 408 Patients Open
Background/Objectives: The concept of frailty has been recognized as an important issue which can influence postoperative outcomes. We aimed to investigate the influence of frailty on clinical and radiological outcomes in patients undergoi…
View article: Traumatic spinal cord injury: a review of the current state of art and future directions – what do we know and where are we going?
Traumatic spinal cord injury: a review of the current state of art and future directions – what do we know and where are we going? Open
While significant strides have been made in understanding the mechanisms underlying SCI and in developing novel therapeutic approaches, the challenge and opportunity will be to tailor treatments to fit the heterogenous clinical presentatio…