Moustafa Sarhan
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View article: N-Alkyl-2-(2-undecyl-1H-benzimidazol-1-yl)acetamides as An-tiproliferative Agents for Invasive Breast Cancer. Design, Syn-thesis, In Vitro Activity, and Computational Studies
N-Alkyl-2-(2-undecyl-1H-benzimidazol-1-yl)acetamides as An-tiproliferative Agents for Invasive Breast Cancer. Design, Syn-thesis, In Vitro Activity, and Computational Studies Open
One of the most dangerous types of breast cancer that can spread from its original location to neighboring tissues is invasive breast cancer. Cathepsins, a group of proteolytic enzymes, has been thoroughly investigated in relation to cance…
View article: <b>Exploring the SARS-CoV-2 spike protein destabilizer toxin from the scorpion, spider, and wasp group of toxins as a promising candidate for the identification of pharmacophores against viral infections</b>
<b>Exploring the SARS-CoV-2 spike protein destabilizer toxin from the scorpion, spider, and wasp group of toxins as a promising candidate for the identification of pharmacophores against viral infections</b> Open
Background: The SARS-CoV-2 virus is the infectious agent that causes coronavirus illness (COVID-19). The majority of virus-infected individuals will recover without the need for special care after experiencing mild to moderate respiratory …
View article: <b><i>In silico</i> evaluation of snake venom proteins against multidrug-resistant <i>Mycobacterium tuberculosis</i>: A molecular dynamics study and simulation dynamic</b>
<b><i>In silico</i> evaluation of snake venom proteins against multidrug-resistant <i>Mycobacterium tuberculosis</i>: A molecular dynamics study and simulation dynamic</b> Open
Background: Mycobacterium tuberculosis (Mtb), a pathogen that belongs to the M. tuberculosis complex (MTBC), causes tuberculosis (TB), an infectious bacterial disease. Although it usually affects the lungs and results in pulmonary tubercul…
View article: Proteomic analysis of the venom of Conus flavidus from Red Sea reveals potential pharmacological applications
Proteomic analysis of the venom of Conus flavidus from Red Sea reveals potential pharmacological applications Open
Our research displayed that the structure of the C. flavidus-derived proteome is similar to other Conus species and includes toxins, ionic channel inhibitors, insulin-like peptides, and hyaluronidase. This study provides a foundation for d…
View article: <b>Molecular docking of eleven snake venom peptides targeting human immunodeficiency virus capsid glycoprotein as inhibitors</b>
<b>Molecular docking of eleven snake venom peptides targeting human immunodeficiency virus capsid glycoprotein as inhibitors</b> Open
Background: Snake venoms are mainly composed of a mixture of proteins and peptides with antiviral activity against several viruses including HIV. Therefore, snake venoms represent promising source for new antiviral drugs. Aim: The study …
View article: Domain analysis of <i>Drosophila</i> Blimp‐1 reveals the importance of its repression function and instability in determining pupation timing
Domain analysis of <i>Drosophila</i> Blimp‐1 reveals the importance of its repression function and instability in determining pupation timing Open
The PRDM family transcription repressor Blimp‐1 is present in almost all multicellular organisms and plays important roles in various developmental processes. This factor has several conserved motifs among different species, but the functi…
View article: Paraphyly of the widespread generalist red fox (<i>Vulpes vulpes</i>): introgression rather than recent divergence of the arid-adapted Rüppell’s fox (<i>Vulpes rueppellii</i>)?
Paraphyly of the widespread generalist red fox (<i>Vulpes vulpes</i>): introgression rather than recent divergence of the arid-adapted Rüppell’s fox (<i>Vulpes rueppellii</i>)? Open
Understanding of the evolutionary history of two closely related canid sister taxa, the geographically restricted, arid-adapted Rüppell’s fox (Vulpes rueppellii) and the widespread generalist red fox (Vulpes vulpes), has been hampered by l…
View article: A new species of Leiurus Ehrenberg (Scorpiones: Buthidae) from Sinai, Egypt and comments on its relationships with L. quinquestriatus and L. hebraeus using morphological and molecular evidence.
A new species of Leiurus Ehrenberg (Scorpiones: Buthidae) from Sinai, Egypt and comments on its relationships with L. quinquestriatus and L. hebraeus using morphological and molecular evidence. Open
The genus Leiurus was first described by Ehrenberg in 1828 as Androctonus (Leiurus) quinquestriatus. For almost two centuries, it was considered monotypic, with only two valid subspecies: Leiurus quinquestriatus quinquestriatus (Ehrenberg,…
View article: A Modified ICSI Technique: Using Zona Pellucida as A Natural Bait
A Modified ICSI Technique: Using Zona Pellucida as A Natural Bait Open
Background: In vivo, the zona pellucida (ZP) of the oocyte can bind to normally functional sperm.The ZP-sperm interaction is one of the final steps of natural selection during their journey in the female reproductive tract.Aim: In the curr…
View article: Total And Mitochondrial Cell Free DNA Quantification in Day 5 Embryos Culture Media Reflect Embryos Quality
Total And Mitochondrial Cell Free DNA Quantification in Day 5 Embryos Culture Media Reflect Embryos Quality Open
Background: In vitro fertilization (IVF) technology still uses the morphological criteria as the main approach for selecting embryos of a certain quality, embryo fragmentation, blastomere size and cleavage rate.This group of tools is routi…
View article: PB2163: SCREENING FOR SUSPECTED AUTOIMMUNE LYMPHOPROLIFERATIVE SYNDROME (ALPS) PATIENTS IN CHILDREN WITH CHRONIC CYTOPENIAS AND NON-MALIGNANT LYMPHADENOPATHY: A STEP FOR BETTER STRATIFICATION.
PB2163: SCREENING FOR SUSPECTED AUTOIMMUNE LYMPHOPROLIFERATIVE SYNDROME (ALPS) PATIENTS IN CHILDREN WITH CHRONIC CYTOPENIAS AND NON-MALIGNANT LYMPHADENOPATHY: A STEP FOR BETTER STRATIFICATION. Open
Background: Autoimmune lymphoproliferative syndrome (ALPS) is a primary immune disorder characterized by chronic, benign lymphoproliferation, autoimmunity, mainly cytopenis, and an increased risk of lymphoma due to a genetic defect in the …
View article: <i>De Novo</i> Sequencing Analysis of a Linear Peptide in the Venom of the Scorpion <i>Buthacus leptochelys</i>
<i>De Novo</i> Sequencing Analysis of a Linear Peptide in the Venom of the Scorpion <i>Buthacus leptochelys</i> Open
Scorpions utilize venom to capture prey and protect themselves from predators by showing neurotoxicity against insects and mammals. The scorpion venom also contains various components such as inorganic salts, nucleic acids, lipids, peptide…
View article: The Femoral Head Epiphysis of Ovariectomized Rats as A Site for Studies on Osteoporosis: Microstructural Changes Evaluations
The Femoral Head Epiphysis of Ovariectomized Rats as A Site for Studies on Osteoporosis: Microstructural Changes Evaluations Open
Background:Osteoporosis is a systemic skeletal disease characterized by decreased bone mass, destruction of the microarchitectonics of bone structure and a high risk for fracture Objective:To explore in detail the structural characteristic…
View article: Virucidal activity of oriental hornet Vespa orientalis venom against hepatitis C virus
Virucidal activity of oriental hornet Vespa orientalis venom against hepatitis C virus Open
WV can inhibit the entry stage of HCV infection at non-cytotoxic concentrations. Therefore, it could be considered a potential candidate for characterization of natural anti-HCV agents targeting the entry step.
View article: Occurrence of Penaeus aztecus, Ives, 1891 (Crustacea: Decapoda: Penaeidae) in the coastal water of Alexandria, Egypt
Occurrence of Penaeus aztecus, Ives, 1891 (Crustacea: Decapoda: Penaeidae) in the coastal water of Alexandria, Egypt Open
A sample of 347 specimens of the northern brown shrimp Penaeus aztecus, a western Atlantic species, was collected from July 2019 to June 2020 by local bottom trawlers off two fishing areas, Abu-Qir Bay and Ma’deya, east of Alexandria Coast…
View article: Inhibitory Activity of a Scorpion Defensin BmKDfsin3 against Hepatitis C Virus
Inhibitory Activity of a Scorpion Defensin BmKDfsin3 against Hepatitis C Virus Open
Hepatitis C virus (HCV) infection is a major worldwide health problem which can cause chronic hepatitis, liver fibrosis and hepatocellular carcinoma (HCC). There is still no vaccine to prevent HCV infection. Currently, the clinical treatme…
View article: A Multiplex PCR-Based Assay for Detection of Plasma Cell Free DNA Integrity as a Marker of Bladder Cancer
A Multiplex PCR-Based Assay for Detection of Plasma Cell Free DNA Integrity as a Marker of Bladder Cancer Open
Background: Cell free DNA (cfDNA) analysis in patient plasma has been suggested for screening of different cancers.Healthy cells may shed more degraded DNA than non-apoptotic tumor cells.Objectives: Our goal was to check whether DNA fragme…
View article: Ecological studies on families Veneridae and Mactridae (Mollusca: Bivalvia) inhabiting the western coasts of the Suez Gulf, Egypt
Ecological studies on families Veneridae and Mactridae (Mollusca: Bivalvia) inhabiting the western coasts of the Suez Gulf, Egypt Open
The faunal composition, abundance, distribution, population density and diversity of bivalve species of families Mactridae and Veneridae were investigated from 11 sites along the western coasts of the Gulf of Suez during the period from su…
View article: Morphological aspects of dorsal fin for eight shark species with special reference to the first records in Egyptian Mediterranean waters, Alexandria, Egypt
Morphological aspects of dorsal fin for eight shark species with special reference to the first records in Egyptian Mediterranean waters, Alexandria, Egypt Open
The present study aimed to describe the dorsal fin measurements used to differentiate between some shark species in Egyptian Mediterranean waters.A total of 43 specimens of sharks were seasonally collected from the commercial catch of the …
View article: Carcharhinid shark species (Family Carcharhinidae), with special reference to the first records in the Egyptian Mediterranean Waters, Alexandria, Egypt.
Carcharhinid shark species (Family Carcharhinidae), with special reference to the first records in the Egyptian Mediterranean Waters, Alexandria, Egypt. Open
First record Mediterranean Sea Egypt morphometric charactersThe present study aimed to provide an update on carcharhinid sharks (Family: Carcharhinidae) in the Egyptian Mediterranean waters, based on the differences in morphological featur…
View article: MOLECULAR PHYLOGENETIC RELATIONS OF MAMMALS OF THE GENUS CANIS IN EGYPT
MOLECULAR PHYLOGENETIC RELATIONS OF MAMMALS OF THE GENUS CANIS IN EGYPT Open
The taxonomic identity of canids of the genus Canis in North Africa has been investigated using molecular phylogenetic analysis based on Cytochrome b mitochondrial DNA sequence analysis.Tissue samples from 18 Canis specimens collected from…
View article: Molecular Differentiation of Haemonchus longistipes Railliet & Henry, 1909 (Nematoda: Trichostrongyloidea) of Female Morphotypes and Male Worms Infecting the Dromedary Camelus dromedarius Using RAPD Technique
Molecular Differentiation of Haemonchus longistipes Railliet & Henry, 1909 (Nematoda: Trichostrongyloidea) of Female Morphotypes and Male Worms Infecting the Dromedary Camelus dromedarius Using RAPD Technique Open
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View article: Isolation and Characterization of Insecticidal Toxins from the Venom of the North African Scorpion, Buthacus leptochelys
Isolation and Characterization of Insecticidal Toxins from the Venom of the North African Scorpion, Buthacus leptochelys Open
Various bioactive peptides have been identified in scorpion venom, but there are many scorpion species whose venom has not been investigated. In this study, we characterized venom components of the North African scorpion, Buthacus leptoche…