Yun‐Ju Lai
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View article: Advances in Nanoplasmonic Biosensors: Optimizing Performance for Exosome Detection Applications
Advances in Nanoplasmonic Biosensors: Optimizing Performance for Exosome Detection Applications Open
The development of sensitive and specific exosome detection tools is essential because they are believed to provide specific information that is important for early detection, screening, diagnosis, and monitoring of cancer. Among the many …
View article: Label-Free Three-Dimensional Morphological Characterization of Cell Death Using Holographic Tomography
Label-Free Three-Dimensional Morphological Characterization of Cell Death Using Holographic Tomography Open
This study presents a novel label-free approach for characterizing cell death states, eliminating the need for complex molecular labeling that may yield artificial or ambiguous results due to technical limitations in microscope resolution.…
View article: The utility of microbiome (microbiota) and exosomes in dentistry
The utility of microbiome (microbiota) and exosomes in dentistry Open
The concept of the oral-systemic link is important in both basic and clinical dentistry. The microbiome (microbiota) and exosomes are two prevalent issues in the modern medical researches. The common advent of oral and general microbiologi…
View article: Advances in Nanoplasmonic Biosensors: Optimizing Performance for Exosome Detection Applications
Advances in Nanoplasmonic Biosensors: Optimizing Performance for Exosome Detection Applications Open
The development of sensitive and specific exosome detection devices is highly desirable because it is believed to deliver specific important information for cancer screening, diagnosis, and monitoring. Among many detection techniques, nano…
View article: IL-6/JAK1 pathway drives PD-L1 Y112 phosphorylation to promote cancer immune evasion
IL-6/JAK1 pathway drives PD-L1 Y112 phosphorylation to promote cancer immune evasion Open
Glycosylation of immune receptors and ligands, such as T cell receptor and coinhibitory molecules, regulates immune signaling activation and immune surveillance. However, how oncogenic signaling initiates glycosylation of coinhibitory mole…
View article: Posttranslational Modifications of PD-L1 and Their Applications in Cancer Therapy
Posttranslational Modifications of PD-L1 and Their Applications in Cancer Therapy Open
Posttranslational modifications (PTM) of PD-L1 have emerged as important regulatory mechanisms that modulate immunosuppression in patients with cancer. In exposure to inflammatory cytokines, cancer cells and antigen-presenting cells, such …
View article: Activation of phagocytosis by immune checkpoint blockade
Activation of phagocytosis by immune checkpoint blockade Open
Inhibition of macrophage-mediated phagocytosis has emerged as an essential mechanism for tumor immune evasion. One mechanism inhibiting the innate response is the presence of the macrophage inhibitory molecule, signal regulatory protein-α …
View article: Small G protein Rac GTPases regulate the maintenance of glioblastoma stem-like cells<i>in vitro</i>and<i>in vivo</i>
Small G protein Rac GTPases regulate the maintenance of glioblastoma stem-like cells<i>in vitro</i>and<i>in vivo</i> Open
Glioblastoma is the most common and aggressive malignant brain tumor in adults. The existence of glioblastoma stem cells (GSCs) or stem-like cells (stemloids) may account for its invasiveness and high recurrence. Rac proteins belong to the…
View article: AKT1 Inhibits Epithelial-to-Mesenchymal Transition in Breast Cancer through Phosphorylation-Dependent Twist1 Degradation
AKT1 Inhibits Epithelial-to-Mesenchymal Transition in Breast Cancer through Phosphorylation-Dependent Twist1 Degradation Open
Epithelial-to-mesenchymal transition (EMT) is an essential physiologic process that promotes cancer cell migration, invasion, and metastasis. Several lines of evidence from both cellular and genetic studies suggest that AKT1/PKBα, but not …