Mi Sun Oh
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View article: Differential Effects of Admission Hemoglobin A <sub>1c</sub> by Estimated Glomerular Filtration Rate Stages on Mortality in Acute Ischemic Stroke and Diabetes
Differential Effects of Admission Hemoglobin A <sub>1c</sub> by Estimated Glomerular Filtration Rate Stages on Mortality in Acute Ischemic Stroke and Diabetes Open
Background The relationship between admission hemoglobin A 1c (HbA 1c ) levels, estimated glomerular filtration rate (eGFR) stages, and early outcomes may provide key insights into the need for individualized glycemic control based on kidn…
View article: Extending Dual Antiplatelet Therapy Beyond 3 Months in Acute Ischemic Stroke Due to Large‐Artery Atherosclerosis
Extending Dual Antiplatelet Therapy Beyond 3 Months in Acute Ischemic Stroke Due to Large‐Artery Atherosclerosis Open
Background The optimal duration of dual antiplatelet therapy (DAPT) with aspirin plus clopidogrel following acute ischemic stroke due to large‐artery atherosclerosis remains uncertain. Methods We retrospectively analyzed data from a prospe…
View article: Distinct spatiotemporal patterns of white matter hyperintensity progression
Distinct spatiotemporal patterns of white matter hyperintensity progression Open
White matter hyperintensity, a key imaging biomarker for brain health, has prognostic implications for stroke. Using a multicenter MRI dataset of 9179 stroke patients plus the UK Biobank (n = 36,210 low/high risk controls), we employ Subty…
View article: Timing of Initiation and Efficacy of Dual Antiplatelet Therapy in Minor Stroke or High-Risk TIA
Timing of Initiation and Efficacy of Dual Antiplatelet Therapy in Minor Stroke or High-Risk TIA Open
Background Dual antiplatelet therapy (DAPT) with aspirin and clopidogrel is recommended within 24 hours for patients with minor ischemic stroke or high-risk transient ischemic attack (TIA). However, the optimal timing for initiating DAPT i…
View article: Long‐Term Outcomes and Predictors in Cancer‐Related Stroke Using the Linked Data Set
Long‐Term Outcomes and Predictors in Cancer‐Related Stroke Using the Linked Data Set Open
Background Data on long‐term prognostic factors in patients with cancer‐related stroke are limited. The purpose of this study was to evaluate long‐term outcomes and investigate prognostic factors of cancer‐related stroke using a linked dat…
View article: Temporal Patterns of Antithrombotic Therapy and Clinical Outcomes After Atrial Fibrillation-Related Stroke
Temporal Patterns of Antithrombotic Therapy and Clinical Outcomes After Atrial Fibrillation-Related Stroke Open
Background There is clinical equipoise in relation to the optimal timing and strategy for antithrombotic therapy in acute ischemic stroke (AIS) patients with atrial fibrillation (AF) who may be eligible for non-vitamin K antagonist oral an…
View article: Oxiracetam and physical activity in preventing cognitive decline after stroke: A multicenter, randomized controlled trial
Oxiracetam and physical activity in preventing cognitive decline after stroke: A multicenter, randomized controlled trial Open
Introduction: This multicenter, double-blind, placebo-controlled trial, commissioned by South Korea’s Ministry of Food and Drug Safety, evaluated the effect of oxiracetam for preventing post-stroke cognitive impairment (PSCI) and explored …
View article: Effectiveness and Safety of Endovascular Treatment in Large Vessel Occlusion Stroke with an NIHSS Score of ≤5 Exhibiting Predominant Cortical Signs
Effectiveness and Safety of Endovascular Treatment in Large Vessel Occlusion Stroke with an NIHSS Score of ≤5 Exhibiting Predominant Cortical Signs Open
Background: Our study aimed to evaluate the impact of EVT on stroke outcomes in patients with LVO with a National Institute of Health Stroke Scale (NIHSS) score of ≤5, exhibiting primarily cortical signs. Methods: We conducted a multicente…
View article: Temporal Trends in Public Stroke Awareness in Korea, 2009 to 2023
Temporal Trends in Public Stroke Awareness in Korea, 2009 to 2023 Open
Background No large‐scale survey on public stroke awareness has been conducted in Korea since 2009. This study assessed temporal trends in awareness of stroke warning signs (WSs) and risk factors (RFs) from 2009 to 2023. We hypothesized th…
View article: Comparing two deep learning algorithms for acute infarct segmentation on diffusion-weighted imaging in routine clinical practice
Comparing two deep learning algorithms for acute infarct segmentation on diffusion-weighted imaging in routine clinical practice Open
Objectives Infarct volumes on diffusion-weighted imaging (DWI) are critical for predicting stroke outcomes and guiding late-window endovascular thrombectomy. Although 3D U-Net-based deep learning achieves high sensitivity, it often yields …
View article: Sex Differences in the Clinical and Imaging Characteristics of Korean CADASIL Patients: A Korean Nationwide Retrospective Study
Sex Differences in the Clinical and Imaging Characteristics of Korean CADASIL Patients: A Korean Nationwide Retrospective Study Open
Background Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a hereditary small vessel disease caused by NOTCH3 mutations. While CADASIL affects both sexes, differences in clinical pres…
View article: Procedure Time of Endovascular Thrombectomy as Performance Measure of Acute Stroke Treatment
Procedure Time of Endovascular Thrombectomy as Performance Measure of Acute Stroke Treatment Open
Purpose: Procedure time (PT), defined as the time between groin access and vessel recanalization, is a recently recognized predictor of outcomes after endovascular thrombectomy (EVT) for acute ischemic stroke (AIS). However, the factors af…
View article: Deep learning-based automatic segmentation of cerebral infarcts on diffusion MRI
Deep learning-based automatic segmentation of cerebral infarcts on diffusion MRI Open
We explored effects of (1) training with various sample sizes of multi-site vs. single-site training data, (2) cross-site domain adaptation, and (3) data sources and features on the performance of algorithms segmenting cerebral infarcts on…
View article: Persistent Beta‐Blocker Therapy Reduces Long‐Term Mortality in Patients With Acute Ischemic Stroke With Elevated Heart Rates
Persistent Beta‐Blocker Therapy Reduces Long‐Term Mortality in Patients With Acute Ischemic Stroke With Elevated Heart Rates Open
Background Elevated heart rate in patients with acute ischemic stroke is associated with increased risk of mortality. Beta‐blocker therapy is well known to reduce heart rate. Methods and Results This study was a post hoc analysis of patien…
View article: Distinct Spatiotemporal Patterns of White Matter Hyperintensity Progression
Distinct Spatiotemporal Patterns of White Matter Hyperintensity Progression Open
White matter hyperintensity (WMH), a key imaging marker for brain health and the most prevalent brain abnormality in the general population, has prognostic implications for stroke. However, as a prognostic factor, WMH is hard to apply beca…
View article: Temporal Trends in Stroke Management and Outcomes Between 2011 and 2020 in South Korea: Results From a Nationwide Multicenter Registry
Temporal Trends in Stroke Management and Outcomes Between 2011 and 2020 in South Korea: Results From a Nationwide Multicenter Registry Open
Background This study aims to evaluate temporal trends of advanced treatments and related clinical outcomes of ischemic stroke through a decade‐long trend analysis, using data from a comprehensive, national, multicenter registry. We also s…
View article: Comparative Effectiveness of Rosuvastatin Versus Atorvastatin in Acute Ischemic Stroke Treatment
Comparative Effectiveness of Rosuvastatin Versus Atorvastatin in Acute Ischemic Stroke Treatment Open
Background Research specifically addressing the efficacy of rosuvastatin versus atorvastatin in patients with ischemic stroke is insufficient. Using a large stroke registry, we investigated whether 2 commonly used statins, rosuvastatin and…
View article: Long-Term Incidence of Gastrointestinal Bleeding Following Ischemic Stroke
Long-Term Incidence of Gastrointestinal Bleeding Following Ischemic Stroke Open
Background and Purpose Previous research on patients with acute ischemic stroke (AIS) has shown a 0.5% incidence of major gastrointestinal bleeding (GIB) requiring blood transfusion during hospitalization. The existing literature has insuf…
View article: Update of the Korean Clinical Practice Guidelines for Stroke: Blood Pressure Management
Update of the Korean Clinical Practice Guidelines for Stroke: Blood Pressure Management Open
Hypertension is a major risk factor for stroke, and appropriate management of blood pressure (BP) is crucial for both prevention and treatment. Since the 2009 publication of the Clinical Practice Guideline (CPG) by the Korean Stroke Societ…
View article: Influence of prestroke glycemic status on outcomes by age in patients with acute ischemic stroke and diabetes mellitus
Influence of prestroke glycemic status on outcomes by age in patients with acute ischemic stroke and diabetes mellitus Open
Background This study aimed to explore the association between admission HbA1c and the risk of 1‐year vascular outcomes stratified by age group in patients with acute ischemic stroke (AIS) and diabetes mellitus (DM). Methods This study ana…
View article: Depression and risk of stroke and mortality after percutaneous coronary intervention: A nationwide population study
Depression and risk of stroke and mortality after percutaneous coronary intervention: A nationwide population study Open
Background Limited evidence exists on the role of depression in the risk of developing stroke and other cardiovascular outcomes in patients who have undergone percutaneous coronary interventions (PCI). We investigated this relationship wit…
View article: Impact of non-traditional lipid profiles on 1-year vascular outcomes in ischemic stroke patients with prior statin therapy and LDL-C < 100 mg/dL
Impact of non-traditional lipid profiles on 1-year vascular outcomes in ischemic stroke patients with prior statin therapy and LDL-C < 100 mg/dL Open
This study aimed to investigate the association between non-traditional lipid profiles and the risk of 1-year vascular events in patients who were already using statins before stroke and had admission LDL-C < 100 mg/dL. This study was an a…
View article: Effects of white matter hyperintensity burden on functional outcome after mild versus moderate-to-severe ischemic stroke
Effects of white matter hyperintensity burden on functional outcome after mild versus moderate-to-severe ischemic stroke Open
It is uncertain whether the prognostic power of white matter hyperintensity (WMH) on post-stroke outcomes is modulated as a function of initial neurological severity, a critical determinant of outcome after stroke. This multi-center MRI st…
View article: Perfusion Imaging‐Based Triage for Acute Ischemic Stroke: Trends in Use and Impact on Clinical Outcomes
Perfusion Imaging‐Based Triage for Acute Ischemic Stroke: Trends in Use and Impact on Clinical Outcomes Open
Background Perfusion imaging (PI) serves as a valuable tool for triaging patients with acute ischemic stroke for endovascular treatment (EVT). This study aims to investigate trends in PI use and its impacts on EVT rates and clinical outcom…
View article: Automated Segmentation of MRI White Matter Hyperintensities in 8421 Patients with Acute Ischemic Stroke
Automated Segmentation of MRI White Matter Hyperintensities in 8421 Patients with Acute Ischemic Stroke Open
We developed and validated deep learning algorithms to segment WMH in patients with acute cerebral infarction using the largest-ever MRI data sets. In addition, we showed that the uncertainty index can be used to identify cases in which au…
View article: Non-Traditional Lipid Profiles and 1-Year Vascular Outcomes in Ischemic Stroke Patients with Prior Statin Therapy and LDL-C &lt;100 mg/dL
Non-Traditional Lipid Profiles and 1-Year Vascular Outcomes in Ischemic Stroke Patients with Prior Statin Therapy and LDL-C <100 mg/dL Open
This study aimed to investigate the association between non-traditional lipid profiles and the risk of 1-year vascular events in patients who were already using statins before stroke and had admission LDL-C < 100 mg/dL. This study was an a…
View article: Optimal use of antithrombotic agents in recent small subcortical strokes accompanied by atrial fibrillation
Optimal use of antithrombotic agents in recent small subcortical strokes accompanied by atrial fibrillation Open
Background: This study aimed to evaluate the efficacy and safety of anticoagulants (AC) and antiplatelets (APT) in patients with recent small subcortical infarctions (RSSI) and atrial fibrillation (AF). Methods: We utilized a prospective m…