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View article: Diagnostic accuracy of swab-based molecular tests for tuberculosis using near-point-of-care platforms: a multi-country evaluation
Diagnostic accuracy of swab-based molecular tests for tuberculosis using near-point-of-care platforms: a multi-country evaluation Open
National Institutes of Health (U01AI152087), Gates Foundation, and Global Health Labs.
View article: Preferences for tongue swab-based versus sputum-based testing in the context of TB care: a best-worst scaling exercise in Vietnam and Zambia
Preferences for tongue swab-based versus sputum-based testing in the context of TB care: a best-worst scaling exercise in Vietnam and Zambia Open
Background The development of non-sputum-based tests is an urgent priority to increase access to tuberculosis (TB) diagnostic testing. Understanding preferences of people undergoing testing is critical for designing tests and strategies al…
View article: Cost and cost-effectiveness of swab-based molecular testing for tuberculosis in the Philippines, Uganda, Vietnam, and Zambia
Cost and cost-effectiveness of swab-based molecular testing for tuberculosis in the Philippines, Uganda, Vietnam, and Zambia Open
Background Tongue swabs (TS) offer a promising alternative to sputum-based molecular testing for tuberculosis. As part of the Tongue Swab Yield (TSwaY) study, we assessed the cost and cost-effectiveness of integrating TS-based testing usin…
View article: Informing People-Centered Target Product Profiles for TB Diagnostics: A Multi-Country Qualitative Study
Informing People-Centered Target Product Profiles for TB Diagnostics: A Multi-Country Qualitative Study Open
Background Timely and accurate tuberculosis (TB) diagnosis remains a key challenge in high-burden settings. The World Health Organization (WHO) has developed Target Product Profiles (TPPs) to guide diagnostic development, which have largel…
View article: Diagnostic yield of tongue swab- compared to sputum-based molecular testing for tuberculosis in four high-burden countries
Diagnostic yield of tongue swab- compared to sputum-based molecular testing for tuberculosis in four high-burden countries Open
Background Tongue swabs are a promising alternative specimen for tuberculosis (TB) diagnosis, with high specificity (>98%) but lower sensitivity than sputum-based molecular tests. We investigated whether increased sample availability could…
View article: Diagnostic accuracy of swab-based molecular tests for tuberculosis using novel near point-of-care platforms: A multi-country evaluation
Diagnostic accuracy of swab-based molecular tests for tuberculosis using novel near point-of-care platforms: A multi-country evaluation Open
Summary Background Swab-based molecular platforms that enable testing of both sputum (via swabs swirled in sputum) and tongue swabs are emerging as a promising option for more accessible and lower cost molecular testing for tuberculosis (T…
View article: Air Embolism after Percutaneous Lung Biopsy or Ablation: A Report of Six Cases
Air Embolism after Percutaneous Lung Biopsy or Ablation: A Report of Six Cases Open
Systemic air embolism following CT-guided percutaneous lung biopsy or ablation is a rare complication associated with asymptomatic to life-threatening clinical presentation. Early detection and prompt, location-specific management are cruc…
View article: Primary renal well‐differentiated neuroendocrine tumors with lymph node metastasis: A case report and literature review
Primary renal well‐differentiated neuroendocrine tumors with lymph node metastasis: A case report and literature review Open
Introduction Well‐differentiated neuroendocrine tumors of the kidney are rare and generally less aggressive than renal cell carcinoma, although metastasis is still present at the time of diagnosis. Surgical resection remains the preferred …
View article: Preferences for tongue swab-versus sputum-based testing in the context of TB care: a Best-Worst Scaling exercise in Vietnam and Zambia
Preferences for tongue swab-versus sputum-based testing in the context of TB care: a Best-Worst Scaling exercise in Vietnam and Zambia Open
Background The development of non-sputum-based tests is an urgent priority to increase access to tuberculosis (TB) diagnostic testing. Understanding preferences of people undergoing testing is critical for designing tests and strategies al…
View article: Diagnosis of paediatric tuberculosis by optically detecting two virulence factors on extracellular vesicles in blood samples
Diagnosis of paediatric tuberculosis by optically detecting two virulence factors on extracellular vesicles in blood samples Open
Sensitive and specific blood-based assays for the detection of pulmonary and extrapulmonary tuberculosis would reduce mortality associated with missed diagnoses, particularly in children. Here we report a nanoparticle-enhanced immunoassay …
View article: Overseas Treatment of Latent Tuberculosis Infection in US–Bound Immigrants
Overseas Treatment of Latent Tuberculosis Infection in US–Bound Immigrants Open
Seventy percent of tuberculosis (TB) cases in the United States occur among non-US-born persons; cases usually result from reactivation of latent TB infection (LTBI) likely acquired before the person's US arrival. We conducted a prospectiv…
View article: Mycobacterium tuberculosis precursor rRNA as a measure of treatment-shortening activity of drugs and regimens
Mycobacterium tuberculosis precursor rRNA as a measure of treatment-shortening activity of drugs and regimens Open
There is urgent need for new drug regimens that more rapidly cure tuberculosis (TB). Existing TB drugs and regimens vary in treatment-shortening activity, but the molecular basis of these differences is unclear, and no existing assay direc…
View article: Four-Month Rifapentine Regimens with or without Moxifloxacin for Tuberculosis
Four-Month Rifapentine Regimens with or without Moxifloxacin for Tuberculosis Open
The efficacy of a 4-month rifapentine-based regimen containing moxifloxacin was noninferior to the standard 6-month regimen in the treatment of tuberculosis. (Funded by the Centers for Disease Control and Prevention and others; Study 31/A5…
View article: Graphical Abstract: Angew. Chem. Int. Ed. 41/2019
Graphical Abstract: Angew. Chem. Int. Ed. 41/2019 Open
GrapheneIn their Communication on page 14446 ff., Z. Liu and co-workers describe the large-scale synthesis of superclean graphene by chemical vapor deposition and the selective etching of amorphous carbon contaminants with CO 2 .
View article: Feasibility of Direct Sputum Molecular Testing for Drug Resistance as Part of Tuberculosis Clinical Trials Eligibility Screening
Feasibility of Direct Sputum Molecular Testing for Drug Resistance as Part of Tuberculosis Clinical Trials Eligibility Screening Open
A rapid diagnosis of drug-resistant tuberculosis (TB) is critical for early initiation of effective therapy. Molecular testing with line probe assays (MTBDRplus and MTBDRsl) on culture isolates has been available for some time and signific…
View article: Sensitivity and characteristics associated with positive QuantiFERON-TB Gold-Plus assay in children with confirmed tuberculosis
Sensitivity and characteristics associated with positive QuantiFERON-TB Gold-Plus assay in children with confirmed tuberculosis Open
Although QFT-Plus had a good sensitivity in children having exclusive PTB, it had poor sensitivity in EPTB.