Yoon Jin
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View article: Preoperative Predictors of Subsequent Breast Cancer Events Detected on Abbreviated MRI in Patients with Early-Stage Breast Cancer
Preoperative Predictors of Subsequent Breast Cancer Events Detected on Abbreviated MRI in Patients with Early-Stage Breast Cancer Open
Background/Objectives: This study aimed to investigate the preoperative clinicopathologic and imaging features associated with subsequent breast cancer events detected on postoperative abbreviated MRI in early-stage breast cancer patients …
View article: Spatial analysis of tumor immune microenvironment of TNBC with different neoadjuvant chemotherapy outcomes using multiplex Immunofluorescence
Spatial analysis of tumor immune microenvironment of TNBC with different neoadjuvant chemotherapy outcomes using multiplex Immunofluorescence Open
In conclusion, our findings suggest that tumoral CD8 + and CD20 + ICs are pivotal determinants of NAC response in TNBC. The enrichment of CD20 + IC under high-TIL conditions underscores the potential role of B-T cell interactions in shapin…
View article: Characterization of pleural metastasis in non-small cell carcinomas undergoing intraoperative frozen section examination
Characterization of pleural metastasis in non-small cell carcinomas undergoing intraoperative frozen section examination Open
Pleural nodularity in operative field strongly indicated pleural metastasis in NSCLC. Additionally, ADC and SqCC exhibited distinct microscopic characteristics, with sclerotic fibrosis frequently accompanying pleural metastasis in ADC.
View article: Anticancer Treatment Influences <i>TREM2</i> in Tumor-Associated Macrophages in Lung Cancer
Anticancer Treatment Influences <i>TREM2</i> in Tumor-Associated Macrophages in Lung Cancer Open
Given TREM2's central inhibitory role in the tumor immune environment, effects of chemotherapeutic agents should be considered in developing TREM2-targeting therapies.
View article: Deep Gaussian process with uncertainty estimation for microsatellite instability and immunotherapy response prediction from histology
Deep Gaussian process with uncertainty estimation for microsatellite instability and immunotherapy response prediction from histology Open
Determining tumor microsatellite status has significant clinical value because tumors that are microsatellite instability-high (MSI-H) or mismatch repair deficient (dMMR) respond well to immune checkpoint inhibitors (ICIs) and oftentimes n…
View article: Multimodal AI model for preoperative prediction of axillary lymph node metastasis in breast cancer using whole slide images
Multimodal AI model for preoperative prediction of axillary lymph node metastasis in breast cancer using whole slide images Open
In breast cancer management, predicting axillary lymph node (ALN) metastasis using whole-slide images (WSIs) of primary tumor biopsies is a challenging and underexplored task for pathologists. We developed METACANS, an multimodal artificia…
View article: Spatial Transcriptomic Landscape of Brain Metastases from Triple-Negative Breast Cancer: Comparison of Primary Tumor and Brain Metastases Using Spatial Analysis
Spatial Transcriptomic Landscape of Brain Metastases from Triple-Negative Breast Cancer: Comparison of Primary Tumor and Brain Metastases Using Spatial Analysis Open
This study provides novel insights into the transcriptional landscapes in TNBC BM using spRNA-seq, emphasizing the role of neuron-tumor interactions and immune dynamics. These findings suggest new therapeutic strategies and underscore the …
View article: Inherent <scp>PD</scp>‐<scp>L1 22C3</scp> Expression in Alveolar Macrophages Impacts the Combined Positive Score Status in Breast Cancer With Pulmonary Metastasis
Inherent <span>PD</span>‐<span>L1 22C3</span> Expression in Alveolar Macrophages Impacts the Combined Positive Score Status in Breast Cancer With Pulmonary Metastasis Open
Purpose This study aimed to determine the impact of inherent programmed death‐ligand 1 (PD‐L1)‐expressing alveolar macrophages (AMs) on the combined positive score (CPS) of PD‐L1 (22C3) in metastatic breast cancer in the lungs. Methods A t…
View article: Genomic Characteristics Related to Histology-Based Immune Features in Breast Cancer
Genomic Characteristics Related to Histology-Based Immune Features in Breast Cancer Open
The immune cell component of the tumor microenvironment is an important modulator of tumor progression. In patients with breast cancer, tumor-infiltrating lymphocytes (TILs) and tertiary lymphoid structures (TLS) represent core aspects of …
View article: Pharmacokinetics and bioequivalence of a molnupiravir tablet formulation compared with the molnupiravir capsule formulation in healthy adult participants—a randomized, open-label, three-period, crossover study
Pharmacokinetics and bioequivalence of a molnupiravir tablet formulation compared with the molnupiravir capsule formulation in healthy adult participants—a randomized, open-label, three-period, crossover study Open
Molnupiravir, a prodrug of β-D-N 4 -hydroxycytidine (NHC), is administered orally as four 200 mg capsules twice daily for 5 days to treat COVID-19. This randomized, open-label, four-treatment sequence, three-period crossover study (NCT0661…
View article: Assessment of pharmacokinetics and tolerability following single‐dose administration of molnupiravir in participants with hepatic or renal impairment
Assessment of pharmacokinetics and tolerability following single‐dose administration of molnupiravir in participants with hepatic or renal impairment Open
Individuals with chronic liver or kidney disease are at increased risk of severe COVID‐19. Molnupiravir is an orally administered antiviral authorized for the treatment of mild‐to‐moderate COVID‐19 in adults at risk of progression to sever…
View article: Deep Gaussian Process with Uncertainty Estimation for Microsatellite Instability and Immunotherapy Response Prediction Based on Histology
Deep Gaussian Process with Uncertainty Estimation for Microsatellite Instability and Immunotherapy Response Prediction Based on Histology Open
Determining tumor microsatellite status has significant clinical value because tumors that are microsatellite instability-high (MSI-H) or mismatch repair deficient (dMMR) respond well to immune check-point inhibitors (ICIs) and oftentimes …
View article: TERT mutations and aggressive histopathologic characteristics of radioiodine-refractory papillary thyroid cancer
TERT mutations and aggressive histopathologic characteristics of radioiodine-refractory papillary thyroid cancer Open
Background: Radioiodine (RI) ablation following thyroid-stimulating hormone suppression is an effective treatment for papillary thyroid cancer (PTC), typically leading to favorable outcomes. However, RI-refractory tumors exhibit aggressive…
View article: UCHL1 Overexpression Is Related to the Aggressive Phenotype of Non-small Cell Lung Cancer
UCHL1 Overexpression Is Related to the Aggressive Phenotype of Non-small Cell Lung Cancer Open
Background: Ubiquitin C-terminal hydrolase L1 (UCHL1), which encodes thiol protease that hydrolyzes a peptide bond at the C-terminal glycine residue of ubiquitin, regulates cell differentiation, proliferation, transcriptional regulation, a…
View article: Histopathologic image–based deep learning classifier for predicting platinum-based treatment responses in high-grade serous ovarian cancer
Histopathologic image–based deep learning classifier for predicting platinum-based treatment responses in high-grade serous ovarian cancer Open
Platinum-based chemotherapy is the cornerstone treatment for female high-grade serous ovarian carcinoma (HGSOC), but choosing an appropriate treatment for patients hinges on their responsiveness to it. Currently, no available biomarkers ca…
View article: Stromal tumor-infiltrating lymphocytes and pathologic response to neoadjuvant chemotherapy with the addition of platinum and pembrolizumab in TNBC: A single-center real-world study
Stromal tumor-infiltrating lymphocytes and pathologic response to neoadjuvant chemotherapy with the addition of platinum and pembrolizumab in TNBC: A single-center real-world study Open
Background Immunochemotherapy with pembrolizumab has been integrated into clinical practice as part of the standard-of-care for non-metastatic triple-negative breast cancer (TNBC) with high risk. We conducted a real-world study in TNBC pat…
View article: Tumor-Infiltrating Lymphocyte Level Consistently Correlates with Lower Stiffness Measured by Shear-Wave Elastography: Subtype-Specific Analysis of Its Implication in Breast Cancer
Tumor-Infiltrating Lymphocyte Level Consistently Correlates with Lower Stiffness Measured by Shear-Wave Elastography: Subtype-Specific Analysis of Its Implication in Breast Cancer Open
Background: We aimed to elucidate the clinical significance of tumor stiffness across breast cancer subtypes and establish its correlation with the tumor-infiltrating lymphocyte (TIL) levels using shear-wave elastography (SWE). Methods: SW…
View article: Predictive Markers of Treatment Response to Neoadjuvant Systemic Therapy with Dual HER2-Blockade
Predictive Markers of Treatment Response to Neoadjuvant Systemic Therapy with Dual HER2-Blockade Open
In patients with human epidermal growth factor receptor 2 (HER2)-positive breast cancer, achievement of pathologic complete response (pCR) is a known prognostic indicator after neoadjuvant systemic therapy (NAST). We investigated the clini…
View article: Development and validation of cardiac diffusion weighted magnetic resonance imaging for the diagnosis of myocardial injury in small animal models
Development and validation of cardiac diffusion weighted magnetic resonance imaging for the diagnosis of myocardial injury in small animal models Open
Cardiac diffusion weighted-magnetic resonance imaging (DWI) has slowly developed due to its technical difficulties. However, this limitation could be overcome by advanced techniques, including a stimulated echo technique and a gradient mom…