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View article: A unique inhibitor conformation selectively targets the DNA polymerase PolC of Gram-positive priority pathogens
A unique inhibitor conformation selectively targets the DNA polymerase PolC of Gram-positive priority pathogens Open
View article: DNA polymerase actively and sequentially displaces single-stranded DNA-binding proteins
DNA polymerase actively and sequentially displaces single-stranded DNA-binding proteins Open
Single-stranded DNA-binding proteins (SSBs) protect transiently exposed ssDNA, yet how DNA polymerase (DNAp) displaces them during replication remains unclear. Using single-molecule force spectroscopy, dual-color imaging, and molecular dyn…
View article: A unique inhibitor conformation selectively targets the DNA polymerase PolC of Gram-positive priority pathogens
A unique inhibitor conformation selectively targets the DNA polymerase PolC of Gram-positive priority pathogens Open
To combat antibiotic-resistant priority pathogens such as methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus faecium, novel antibiotics are urgently needed1-3. DNA polymerases, essential for DNA replication b…
View article: A new pathway in central metabolism mediates nutrient control of development and antibiotic production by<i>Streptomyces</i>
A new pathway in central metabolism mediates nutrient control of development and antibiotic production by<i>Streptomyces</i> Open
The amino sugar N- acetylglucosamine (GlcNAc) plays a central role in primary metabolism and is a key signaling molecule for the onset of morphological and chemical differentiation of Streptomyces . The global nutrient-sensory regulator Da…
View article: Taxonomic and metabolic diversity of <scp>Actinomycetota</scp> isolated from faeces of a 28,000‐year‐old mammoth
Taxonomic and metabolic diversity of <span>Actinomycetota</span> isolated from faeces of a 28,000‐year‐old mammoth Open
Ancient environmental samples, including permafrost soils and frozen animal remains, represent an archive with microbial communities that have barely been explored. This yet unexplored microbial world is a genetic resource that may provide…
View article: Systems-wide analysis of the ROK-family regulatory gene <i>rokL6</i> and its role in the control of glucosamine toxicity in <i>Streptomyces coelicolor</i>
Systems-wide analysis of the ROK-family regulatory gene <i>rokL6</i> and its role in the control of glucosamine toxicity in <i>Streptomyces coelicolor</i> Open
Streptomycetes are saprophytic bacteria that grow on complex polysaccharides, such as cellulose, starch, chitin, and chitosan. For the monomeric building blocks glucose, maltose, and N -acetylglucosamine, the metabolic pathways are well-do…
View article: Systems-wide analysis of the ROK-family regulatory gene<i>rokL6</i>and its role in the control of glucosamine toxicity in<i>Streptomyces coelicolor</i>
Systems-wide analysis of the ROK-family regulatory gene<i>rokL6</i>and its role in the control of glucosamine toxicity in<i>Streptomyces coelicolor</i> Open
Streptomycetes are saprophytic bacteria that grow on complex polysaccharides, such as cellulose, starch, chitin and chitosan. For the monomeric building blocks glucose, maltose and N -acetylglucosamine (GlcNAc), the metabolic pathways are …
View article: Taxonomic and metabolic diversity of Actinobacteria isolated from faeces of a 28,000-year-old mammoth
Taxonomic and metabolic diversity of Actinobacteria isolated from faeces of a 28,000-year-old mammoth Open
Ancient microbial communities of permafrost soils and frozen animal remains represent an archive that has barely been explored. This yet unexplored microbial world is a vast resource that can provide us with new evolutionary insights, meta…
View article: Intertwining nutrient‐sensory networks and the control of antibiotic production in<i>Streptomyces</i>
Intertwining nutrient‐sensory networks and the control of antibiotic production in<i>Streptomyces</i> Open
Summary Actinobacteria are producers of a plethora of natural products of agricultural, biotechnological and clinical importance. In an era where mankind has to deal with rapidly spreading antimicrobial resistance, streptomycetes are of pa…
View article: OsdR of Streptomyces coelicolor and the Dormancy Regulator DevR of Mycobacterium tuberculosis Control Overlapping Regulons
OsdR of Streptomyces coelicolor and the Dormancy Regulator DevR of Mycobacterium tuberculosis Control Overlapping Regulons Open
Dormancy is a state of growth cessation that allows bacteria to escape the host defense system and antibiotic challenge. Understanding the mechanisms that control dormancy is of key importance for the treatment of latent infections, such a…
View article: Multiple allosteric effectors control the affinity of DasR for its target sites
Multiple allosteric effectors control the affinity of DasR for its target sites Open