Miaoling Li
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View article: Impact of percutaneous coronary intervention with different guidance modalities in patients with coronary artery lesions: a network meta-analysis and systematic review
Impact of percutaneous coronary intervention with different guidance modalities in patients with coronary artery lesions: a network meta-analysis and systematic review Open
Background Traditional coronary angiography has inherent limitations in terms of lesion assessment and stenting. New guidance modalities to guide percutaneous coronary intervention (PCI) are now available. Methods We systematically searche…
View article: Intracellular calcium dysregulation in heart and brain diseases: Insights from induced pluripotent stem cell studies
Intracellular calcium dysregulation in heart and brain diseases: Insights from induced pluripotent stem cell studies Open
The central nervous system (CNS) plays a role in regulating heart rate and myocardial contractility through sympathetic and parasympathetic nerves, and the heart can impact the functional equilibrium of the CNS through feedback signals. Al…
View article: Restoration of Mitochondrial Function Is Essential in the Endothelium-Dependent Vasodilation Induced by Acacetin in Hypertensive Rats
Restoration of Mitochondrial Function Is Essential in the Endothelium-Dependent Vasodilation Induced by Acacetin in Hypertensive Rats Open
Mitochondrial dysfunction in the endothelium contributes to the progression of hypertension and plays an obligatory role in modulating vascular tone. Acacetin is a natural flavonoid compound that has been shown to possess multiple benefici…
View article: CircRNA ATF6 promotes ovarian cancer cell progression by activating PTEN/mTOR signaling pathway
CircRNA ATF6 promotes ovarian cancer cell progression by activating PTEN/mTOR signaling pathway Open
Ovarian cancer is a malignant cancer type and affects women’s lives in the world. Circular RNAs (circRNAs) have been involved with the progression of cancers. In our study, we are going to explore the functions of circATF6 in ovarian cance…
View article: [Retracted] Ginsenoside Rg3 Alleviates Antithyroid Cancer Drug Vandetanib‐Induced QT Interval Prolongation
[Retracted] Ginsenoside Rg3 Alleviates Antithyroid Cancer Drug Vandetanib‐Induced QT Interval Prolongation Open
Inhibition of human ether‐a‐go‐go‐related gene (hERG) potassium channel is responsible for acquired long QT syndromes, which leads to life‐threatening cardiac arrhythmia. A multikinase inhibitor, vandetanib, prolongs the progression‐free s…
View article: Stimulation of Sigma‐1 Receptor Protects against Cardiac Fibrosis by Alleviating IRE1 Pathway and Autophagy Impairment
Stimulation of Sigma‐1 Receptor Protects against Cardiac Fibrosis by Alleviating IRE1 Pathway and Autophagy Impairment Open
Sigma‐1 receptor (Sig1R), a chaperone in the endoplasmic reticulum (ER) membrane, has been implicated in cardiac hypertrophy; however, its role in cardiac fibroblast activation has not been established. This study investigated the possible…
View article: Inhibitory Effects of Dronedarone on Small Conductance Calcium Activated Potassium Channels in Patients with Chronic Atrial Fibrillation: Comparison to Amiodarone
Inhibitory Effects of Dronedarone on Small Conductance Calcium Activated Potassium Channels in Patients with Chronic Atrial Fibrillation: Comparison to Amiodarone Open
BACKGROUND Dysfunction of small conductance calcium activated potassium (SK) channels plays a vital role in atrial arrhythmogenesis. Amiodarone and dronedarone are the most effective class III antiarrhythmic drugs. It is unclear whether th…
View article: Inhibition of P2X7 Purinergic Receptor Ameliorates Cardiac Fibrosis by Suppressing NLRP3/IL-1<i>β</i> Pathway
Inhibition of P2X7 Purinergic Receptor Ameliorates Cardiac Fibrosis by Suppressing NLRP3/IL-1<i>β</i> Pathway Open
P2X7 purinergic receptor (P2X7R) has been implicated in several cardiovascular diseases. However, whether it regulates cardiac fibrosis remains elusive. Herein, its involvement in the development of cardiac fibrosis was examined using a tr…
View article: Constant Light Exerted Detrimental Cardiovascular Effects Through Sympathetic Hyperactivity in Normal and Heart Failure Rats
Constant Light Exerted Detrimental Cardiovascular Effects Through Sympathetic Hyperactivity in Normal and Heart Failure Rats Open
It has been documented that constant light exposure exerts complicated cardiovascular effects. However, a mounting collection of conflicting results did not make it any easier for researchers and physicians to consider the role of light on…
View article: Upregulation of Transient Receptor Potential Canonical Type 3 Channel via AT1R/TGF-<i>β</i>1/Smad2/3 Induces Atrial Fibrosis in Aging and Spontaneously Hypertensive Rats
Upregulation of Transient Receptor Potential Canonical Type 3 Channel via AT1R/TGF-<i>β</i>1/Smad2/3 Induces Atrial Fibrosis in Aging and Spontaneously Hypertensive Rats Open
Fibroblast proliferation and migration are central in atrial fibrillation (AF) promoting structure remodeling, which is strongly associated with aging and hypertension. Transient receptor potential canonical-3 channel (TRPC3) is a key medi…
View article: New Insights Into Interactions of Presynaptic Calcium Channel Subtypes and SNARE Proteins in Neurotransmitter Release
New Insights Into Interactions of Presynaptic Calcium Channel Subtypes and SNARE Proteins in Neurotransmitter Release Open
Action potential (AP) induces presynaptic membrane depolarization and subsequent opening of Ca2+ channels, and then triggers neurotransmitter release at the active zone of presynaptic terminal. Presynaptic Ca2+ channels and SNARE proteins …
View article: An Analysis of the Effects of Internal Medicine Training before Clinical Practice Based on the OSCE
An Analysis of the Effects of Internal Medicine Training before Clinical Practice Based on the OSCE Open
Objective: To explore a teaching mode that can improve medical students' clinical competence by internal training before clinical practice and an analysis of its effectiveness. Methods: According to the OSCE, eight-year medical students we…
View article: Sodium Tanshinone IIA Sulfonate Prevents Angiotensin II‐Induced Differentiation of Human Atrial Fibroblasts into Myofibroblasts
Sodium Tanshinone IIA Sulfonate Prevents Angiotensin II‐Induced Differentiation of Human Atrial Fibroblasts into Myofibroblasts Open
Differentiation of atrial fibroblasts into myofibroblasts plays a critical role in atrial fibrosis. Sodium tanshinone IIA sulfonate (DS‐201), a water‐soluble derivative of tanshinone IIA, has been shown to have potent antifibrotic properti…
View article: Ca2+/Calmodulin-Dependent Protein Kinase II (CaMKII) Increases Small-Conductance Ca2+-Activated K+ Current in Patients with Chronic Atrial Fibrillation
Ca2+/Calmodulin-Dependent Protein Kinase II (CaMKII) Increases Small-Conductance Ca2+-Activated K+ Current in Patients with Chronic Atrial Fibrillation Open
BACKGROUND Increased small-conductance Ca2+-activated K+ current (SK), abnormal intracellular Ca2+ handling, and enhanced expression and activity of Ca2+/calmodulin-dependent protein kinase II (CaMKII) have been found in clinical and/or ex…
View article: Numerical Analysis of Solid Materials Transport in a Rotary Dryer
Numerical Analysis of Solid Materials Transport in a Rotary Dryer Open
The throwing motion of materials in the rotary dryer is the key step to dry off.An estimation model of solid material transport was established.The motion rule about the lifted materials was studied.The numerical model was proposed accordi…
View article: Issue Information
Issue Information Open
Cardiovascular Therapeutics (formerly Cardiovascular Drug Reviews) focuses on extensive reviews
View article: Shear stress regulates endothelial cell function through <scp>SRB</scp>1‐<scp>eNOS</scp> signaling pathway
Shear stress regulates endothelial cell function through <span>SRB</span>1‐<span>eNOS</span> signaling pathway Open
Summary Aim The aim of this study was to explore whether transmembrane flow shear stress could regulate eNOS expression and mediate endothelial cell function via SR ‐B1 signaling transduction. Methods Parallel‐plate flow chamber was used t…
View article: Myricetin inhibits Kv1.5 channels in HEK293 cells
Myricetin inhibits Kv1.5 channels in HEK293 cells Open
Myricetin (Myr) is a flavonoid that exerts anti-arrhythmic effects. However, its potential effects on ion channels have remained elusive. The aim of the present study was to investigate the effects of Myr on Kv1.5 channels in HEK293 cells.…