Miaoran Xia
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View article: A Comparative Analysis of the Immunoglobulin Repertoire in Leukemia Cells and B Cells in Chinese Acute Myeloid Leukemia by High-Throughput Sequencing
A Comparative Analysis of the Immunoglobulin Repertoire in Leukemia Cells and B Cells in Chinese Acute Myeloid Leukemia by High-Throughput Sequencing Open
It is common knowledge that immunoglobulin (Ig) is produced by B lymphocytes and mainly functions as an antibody. However, it has been shown recently that myeloblasts from acute myeloid leukemia (AML) could also express Ig and that AML-Ig …
View article: Lsd1 safeguards T-cell development via suppressing endogenous retroelements and interferon responses
Lsd1 safeguards T-cell development via suppressing endogenous retroelements and interferon responses Open
The histone demethylase Lsd1 has been shown to play multiple essential roles in mammalian biology. However, its physiological functions in thymocyte development remain elusive. We observed that the specific deletion of Lsd1 in thymocytes c…
View article: Ablation of Lsd1 induces viral mimicry in thymocytes and promotes the development of innate-memory T cells
Ablation of Lsd1 induces viral mimicry in thymocytes and promotes the development of innate-memory T cells Open
Histone demethylase Lsd1 has been shown to play a critical role in hematopoietic differentiation. However, its physiological functions in thymocyte development remain elusive. We observed that the specific deletion of Lsd1 in thymocytes at…
View article: Next-Generation Sequencing Revealed a Distinct Immunoglobulin Repertoire with Specific Mutation Hotspots in Acute Myeloid Leukemia
Next-Generation Sequencing Revealed a Distinct Immunoglobulin Repertoire with Specific Mutation Hotspots in Acute Myeloid Leukemia Open
Immunoglobulin (Ig) is known as a hallmark of B-lymphocytes exerting antibody functions. However, our previous studies demonstrated that myeloblasts from acute myeloid leukemia (AML) patients could also express Ig with distinct roles. Here…
View article: Epigenetic Regulation of NK Cell-Mediated Antitumor Immunity
Epigenetic Regulation of NK Cell-Mediated Antitumor Immunity Open
Natural killer (NK) cells are critical innate lymphocytes that can directly kill target cells without prior immunization. NK cell activation is controlled by the balance of multiple germline-encoded activating and inhibitory receptors. NK …
View article: Functional analysis of BRCT missense mutations in BRCA1‑mutated Chinese Han familial breast cancer
Functional analysis of BRCT missense mutations in BRCA1‑mutated Chinese Han familial breast cancer Open
Breast cancer 1 (BRCA1) is one of the most common tumor suppressor genes in breast cancer. The BRCT domain of BRCA1 has been shown to have a critical role in tumor suppression. In a previous study, two de novo BRCT missense mutations of BR…