Mengru Zhang
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View article: Efficacy and safety of flupentixol-melitracen in patients with refractory chronic cough: a randomised, double-blinded, placebo-controlled clinical trial
Efficacy and safety of flupentixol-melitracen in patients with refractory chronic cough: a randomised, double-blinded, placebo-controlled clinical trial Open
The Project of Science and Technology Commission of Shanghai Municipality.
View article: Azithromycin and oesophageal motility in chronic respiratory disease: a feasibility study
Azithromycin and oesophageal motility in chronic respiratory disease: a feasibility study Open
Background: The role of the gut-lung axis in respiratory disease is increasingly recognised. Much emphasis has been placed on gastro-oesophageal reflux disease; however, oesophageal dysmotility may also play a significant role. Azithromyci…
View article: From precision synthesis to cross-industry applications: The future of emerging peptide technologies
From precision synthesis to cross-industry applications: The future of emerging peptide technologies Open
Peptides, derived primarily from natural bioactive sources, play essential roles in human physiological processes such as hormone regulation and nerve signal transmission. Recent advances in phage display technology have revolutionized pep…
View article: Reply to “Interrupting a vicious cycle in order to produce cessation of refractory chronic cough”
Reply to “Interrupting a vicious cycle in order to produce cessation of refractory chronic cough” Open
View article: Expression of PDZ domain-containing proteins is correlated with prognosis and immune infiltration in hepatocellular carcinoma
Expression of PDZ domain-containing proteins is correlated with prognosis and immune infiltration in hepatocellular carcinoma Open
PDZ proteins may serve as prognostic markers and therapeutic targets in HCC. DEP-related risk scores offer insights into immune infiltration patterns and treatment responsiveness, providing a foundation for future HCC research and developm…
View article: Integrated Metabolomics and Network Pharmacology to Reveal the Mechanisms of Forsythia suspensa Extract Against Respiratory Syncytial Virus
Integrated Metabolomics and Network Pharmacology to Reveal the Mechanisms of Forsythia suspensa Extract Against Respiratory Syncytial Virus Open
To investigate the therapeutic impact of Forsythia suspensa extract (FS) on RSV-infected mice and explore its antiviral pharmacodynamic foundations. Methods: An integrated analytical approach, combining UPLC-Q-TOF/MS with network pharmacol…
View article: Atherogenic index of plasma, high sensitivity C-reactive protein and incident diabetes among middle-aged and elderly adults in China: a national cohort study
Atherogenic index of plasma, high sensitivity C-reactive protein and incident diabetes among middle-aged and elderly adults in China: a national cohort study Open
View article: Contradictory Role of Gadd45β in Liver Diseases
Contradictory Role of Gadd45β in Liver Diseases Open
There are three homologous proteins (α, β and γ) in the growth arrest and DNA damage 45 (Gadd45) family. These proteins act as cellular responders to physiological and environmental stimuli. Gadd45β plays a significant role in the pathogen…
View article: Correspondence Regarding Lee et al.: Placebo Control is Vital in Assessing Therapy in Chronic Cough
Correspondence Regarding Lee et al.: Placebo Control is Vital in Assessing Therapy in Chronic Cough Open
View article: Coughing our guts up: how do we diagnose reflux cough?
Coughing our guts up: how do we diagnose reflux cough? Open
Should Peptest be routinely used in a cough clinic? The answer is yes, but only as part of more intricate workup in which discovering the nature of the reflux is as important as identifying its presence. https://bit.ly/3QkbChb.
View article: Decoding the impact of the placebo response in clinical trials for chronic cough
Decoding the impact of the placebo response in clinical trials for chronic cough Open
Chronic cough is a prevalent and challenging condition, with limited treatment options available. The interpretation of clinical trial results for antitussive drugs is complicated by the presence of the placebo response, which can confound…
View article: Role of alveolar nitric oxide in gastroesophageal reflux-associated cough: prospective observational study
Role of alveolar nitric oxide in gastroesophageal reflux-associated cough: prospective observational study Open
Background: Fractional exhaled nitric oxide (FeNO) measured at multiple exhalation flow rates can be used as a biomarker to differentiate central and peripheral airway inflammation. However, the role of alveolar nitric oxide (CaNO) indicat…
View article: Unravelling vagal hypersensitivity in chronic cough: A distinct disease
Unravelling vagal hypersensitivity in chronic cough: A distinct disease Open
Chronic cough (CC) is a common but poorly understood disease that has a negative impact on quality of life. For years, clinicians have been trying to find the underlying diagnosis and using existing disease models to describe the patients’…
View article: The “vicious circle” of chronic cough: the patient experience – qualitative synthesis
The “vicious circle” of chronic cough: the patient experience – qualitative synthesis Open
Aim The aim of this study was to systematically search and synthesise findings from peer-reviewed qualitative studies describing the experiences of those living with chronic cough. Methods A systematic search was conducted to identify all …
View article: Subcutaneous octreotide as a therapeutic option for refractory chronic cough: subjective response pattern and adverse effects from a retrospective single-centre case series
Subcutaneous octreotide as a therapeutic option for refractory chronic cough: subjective response pattern and adverse effects from a retrospective single-centre case series Open
Therapeutic antitussive effect of octreotide on intractable cough https://bit.ly/3mVMEc6.
View article: Pathogenesis and management of gastroesophageal reflux disease-associated cough: a narrative review
Pathogenesis and management of gastroesophageal reflux disease-associated cough: a narrative review Open
Tracheobronchial-esophageal reflex might initiate reflux-induced cough provoked by the upper respiratory tract infection. It is necessary to optimize the current standards and to explore new criteria with higher diagnostic potency. Acid su…
View article: Improved diagnostic yield of symptom association probability involving only cough for gastroesophageal reflux-induced chronic cough
Improved diagnostic yield of symptom association probability involving only cough for gastroesophageal reflux-induced chronic cough Open
C-SAP was superior to T-SAP for the identification of GERC and may improve the diagnostic yield of GERC.
View article: Mean Nocturnal Baseline Impedance (MNBI) Provides Evidence for Standardized Management Algorithms of Nonacid Gastroesophageal Reflux-Induced Chronic Cough
Mean Nocturnal Baseline Impedance (MNBI) Provides Evidence for Standardized Management Algorithms of Nonacid Gastroesophageal Reflux-Induced Chronic Cough Open
Background. The clinical management of nonacid gastroesophageal reflux-induced chronic cough (GERC) is challenging, and patient response to standard antireflux therapy (omeprazole 20 mg twice daily plus mosapride 10 mg thrice daily) is sub…
View article: Antitussive efficacy of the current treatment protocol for refractory chronic cough: our real-world experience in a retrospective cohort study
Antitussive efficacy of the current treatment protocol for refractory chronic cough: our real-world experience in a retrospective cohort study Open
Background: The management of refractory chronic cough (RCC) is a great challenge. Neuromodulators have long been used for RCC with imperfect efficacy. Objectives: We summarized the outcomes of the current treatments used at our specialist…
View article: miR-101-3p improves neuronal morphology and attenuates neuronal apoptosis in ischemic stroke in young mice by downregulating HDAC9
miR-101-3p improves neuronal morphology and attenuates neuronal apoptosis in ischemic stroke in young mice by downregulating HDAC9 Open
Objective MiRNAs play a key role in ischemic stroke (IS). Although miR-101-3p can participate in multiple disease processes, its role and mechanism in IS are not clear. The aim of the present study was to observe the effect of miR-101-3p a…
View article: New Insights Into Refractory Chronic Cough and Unexplained Chronic Cough: A 6-Year Ambispective Cohort Study
New Insights Into Refractory Chronic Cough and Unexplained Chronic Cough: A 6-Year Ambispective Cohort Study Open
The current treatments only improve cough symptoms in two-thirds of patients. Clinical indicators for treatment failure were those coughing for long duration and being sensitive to "talking" or "cold air."
View article: Chronic cough—the limitation and advances in assessment techniques
Chronic cough—the limitation and advances in assessment techniques Open
Accurate and consistent assessments of cough are essential to advance the understanding of the mechanisms of cough and individualised the management of patients. Considerable progress has been made in this work. Here we reviewed the curren…
View article: A Study on Cough Sensitivity and Airway Inflammation in Patients with Sinobronchial Syndrome
A Study on Cough Sensitivity and Airway Inflammation in Patients with Sinobronchial Syndrome Open
Objective. This study aimed to clarify the characteristics of cough-reflex sensitivity and airway inflammation in patients with sinobronchial syndrome (SBS). Methods. 39 patients with SBS, 53 patients with upper airway cough syndrome (UACS…
View article: ATP, an attractive target for the treatment of refractory chronic cough
ATP, an attractive target for the treatment of refractory chronic cough Open
View article: Treatment of chronic cough: P2X3 receptor antagonists and beyond
Treatment of chronic cough: P2X3 receptor antagonists and beyond Open
View article: Chronic cough in cystic fibrosis: the effect of modulator therapy on objective 24-h cough monitoring
Chronic cough in cystic fibrosis: the effect of modulator therapy on objective 24-h cough monitoring Open
This is a prospective observation of the effect of Kaftrio initiation in CF. An early and dramatic improvement in the objective measure of 24-h cough monitoring was observed, providing noninvasive, objective evidence of efficacy and com…
View article: Diagnostic value of reflux episodes in gastroesophageal reflux-induced chronic cough: a novel predictive indicator
Diagnostic value of reflux episodes in gastroesophageal reflux-induced chronic cough: a novel predictive indicator Open
Background: Multichannel intraluminal impedance and pH-monitoring (MII-pH) is an essential testing modality for gastroesophageal reflux-induced chronic cough (GERC), while the existing diagnostic criteria still have some inherent defects. …
View article: Treatment of Chronic Cough: P2X3 Receptor Antagonists and Beyond
Treatment of Chronic Cough: P2X3 Receptor Antagonists and Beyond Open
View article: Pressure and length of the lower esophageal sphincter as predictive indicators of therapeutic efficacy of baclofen for refractory gastroesophageal reflux-induced chronic cough
Pressure and length of the lower esophageal sphincter as predictive indicators of therapeutic efficacy of baclofen for refractory gastroesophageal reflux-induced chronic cough Open
View article: Can acid exposure time replace the DeMeester score in the diagnosis of gastroesophageal reflux-induced cough?
Can acid exposure time replace the DeMeester score in the diagnosis of gastroesophageal reflux-induced cough? Open
Background: The objective of this study was to compare the predictive accuracy of the acid exposure time (AET) with the DeMeester score (DMS) for gastroesophageal reflux–induced cough (GERC). Methods: A total of 277 patients who underwent …