Miaoying Shi
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View article: Phthalates exposure as a risk factor for gestational diabetes mellitus: Integrated evidence from epidemiological and human liver organoids studies
Phthalates exposure as a risk factor for gestational diabetes mellitus: Integrated evidence from epidemiological and human liver organoids studies Open
View article: Predicting the developmental toxicity of 8-methyl-benzo[a]pyrene (BaP) by physiologically based kinetic (PBK) modeling-facilitated reverse dosimetry and read-across from BaP
Predicting the developmental toxicity of 8-methyl-benzo[a]pyrene (BaP) by physiologically based kinetic (PBK) modeling-facilitated reverse dosimetry and read-across from BaP Open
The present study predicts an in vivo dose-response curve for developmental toxicity of 8-methyl-benzo[a]pyrene (8-MBaP) in rats using PBK model-facilitated reverse dosimetry and read-across from a previously developed model for BaP. As fo…
View article: Deriving a Health-Based Guidance Value for 9,10-Anthraquinone via integrating PBTK modeling-based reverse dosimetry and In Vitro bioassays
Deriving a Health-Based Guidance Value for 9,10-Anthraquinone via integrating PBTK modeling-based reverse dosimetry and In Vitro bioassays Open
View article: Macrophage polarization as a novel endpoint for assessing combined risk of phthalate esters
Macrophage polarization as a novel endpoint for assessing combined risk of phthalate esters Open
Combined exposure to phthalate esters (PAEs) has garnered increasing attention due to potential synergistic effects on human health. This study aimed to develop an in vitro model using human macrophages to evaluate the combined toxicity of…
View article: Macrophage Polarization as a Novel Endpoint for Assessing Combined Risk of Phthalate Esters
Macrophage Polarization as a Novel Endpoint for Assessing Combined Risk of Phthalate Esters Open
View article: Advancing food safety risk assessment in China: development of new approach methodologies (NAMs)
Advancing food safety risk assessment in China: development of new approach methodologies (NAMs) Open
Novel techniques and methodologies are being developed to advance food safety risk assessment into the next-generation. Considering the shortcomings of traditional animal testing, new approach methodologies (NAMs) will be the main tools fo…
View article: In vitro–in silico-based prediction of inter-individual and inter-ethnic variations in the dose-dependent cardiotoxicity of R- and S-methadone in humans
In vitro–in silico-based prediction of inter-individual and inter-ethnic variations in the dose-dependent cardiotoxicity of R- and S-methadone in humans Open
View article: A novel method for predicting human cardiotoxicity without animal testing
A novel method for predicting human cardiotoxicity without animal testing Open
Propositions 1. Human induced pluripotent stem-cell derived cardiomyocytes in combination with the multi-electrode array technique provide adequate input for predicting human cardiotoxicity without animal testing.(this thesis) 2. Quantifyi…
View article: A new approach methodology (NAM) for the prediction of (nor)ibogaine-induced cardiotoxicity in humans
A new approach methodology (NAM) for the prediction of (nor)ibogaine-induced cardiotoxicity in humans Open
The development of non-animal-based new approach methodologies (NAMs) for chemical risk assessment and safety evaluation is urgently needed. The aim of the present study was to investigate the applicability of an in vitro-in silico approac…
View article: Evaluation of in vitro models of stem cell-derived cardiomyocytes to screen for potential cardiotoxicity of chemicals
Evaluation of in vitro models of stem cell-derived cardiomyocytes to screen for potential cardiotoxicity of chemicals Open
View article: Integrating in vitro data and physiologically based kinetic modeling-facilitated reverse dosimetry to predict human cardiotoxicity of methadone
Integrating in vitro data and physiologically based kinetic modeling-facilitated reverse dosimetry to predict human cardiotoxicity of methadone Open