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View article: NNMT/1-MNA protects against hepatic ischemia-reperfusion injury through the AKT/FOXO1/ANGPT2/JNK axis
NNMT/1-MNA protects against hepatic ischemia-reperfusion injury through the AKT/FOXO1/ANGPT2/JNK axis Open
Hepatic ischemia‒reperfusion injury (HIRI) occurs during liver surgery, contributing to postoperative complications such as liver failure, prolonged hospital stays, and increased morbidity and mortality rates. Yet, the mechanism underlying…
View article: Arsenic trioxide preconditioning attenuates hepatic ischemia- reperfusion injury in mice: Role of ERK/AKT and autophagy
Arsenic trioxide preconditioning attenuates hepatic ischemia- reperfusion injury in mice: Role of ERK/AKT and autophagy Open
Background: Arsenic trioxide (ATO) is indicated as a broad-spectrum medicine for a variety of diseases, including cancer and cardiac disease. While the role of ATO in hepatic ischemia/reperfusion injury (HIRI) has not been reported. Thus, …
View article: Von Hippel-Lindau deficiency protects the liver against ischemia/reperfusion injury through the regulation of hypoxia-inducible factor 1α and 2α
Von Hippel-Lindau deficiency protects the liver against ischemia/reperfusion injury through the regulation of hypoxia-inducible factor 1α and 2α Open
Background: Ischemia and reperfusion (I/R)-induced liver injury contributes to morbidity and mortality during hepatic surgery or liver transplantation. As a pivotal regulator of cancer and inflammation, the role of Von Hippel-Lindau (VHL) …
View article: Identification and validation of ferroptosis-related hub genes and immune infiltration in liver ischemia-reperfusion injury
Identification and validation of ferroptosis-related hub genes and immune infiltration in liver ischemia-reperfusion injury Open
Ischemia-reperfusion injury (IRI) is a cumulation of pathophysiological processes that involves cell and organelle damage upon blood flow constraint and subsequent restoration. However, studies on overall immune infiltration and ferroptosi…
View article: RGS19 activates the MYH9/β-catenin/c-Myc positive feedback loop in hepatocellular carcinoma
RGS19 activates the MYH9/β-catenin/c-Myc positive feedback loop in hepatocellular carcinoma Open
Hepatocellular carcinoma (HCC) is one of the most common fatal cancers worldwide, and the identification of novel treatment targets and prognostic biomarkers is urgently needed because of its unsatisfactory prognosis. Regulator of G-protei…
View article: <scp>IRG1</scp> restrains <scp>M2</scp> macrophage polarization and suppresses intrahepatic cholangiocarcinoma progression via the <scp>CCL18</scp>/<scp>STAT3</scp> pathway
<span>IRG1</span> restrains <span>M2</span> macrophage polarization and suppresses intrahepatic cholangiocarcinoma progression via the <span>CCL18</span>/<span>STAT3</span> pathway Open
Intrahepatic cholangiocarcinoma (ICC) is a highly malignant and aggressive cancer whose incidence and mortality continue to increase, whereas its prognosis remains dismal. Tumor‐associated macrophages (TAMs) promote malignant progression a…
View article: TMEM147 aggravates the progression of HCC by modulating cholesterol homeostasis, suppressing ferroptosis, and promoting M2 polarization of TAMs
TMEM147 aggravates the progression of HCC by modulating cholesterol homeostasis, suppressing ferroptosis, and promoting M2 polarization of TAMs Open
Background: The endoplasmic reticulum (ER) regulates critical processes, including lipid synthesis, which can be affected by transmembrane proteins localized in the ER membrane. One of them, the transmembrane protein 147 (TMEM147) has been…
View article: Comprehensive analysis of the prognostic value and functions of prefoldins in hepatocellular carcinoma
Comprehensive analysis of the prognostic value and functions of prefoldins in hepatocellular carcinoma Open
Prefoldins (PFDNs), a group of proteins known to be associated with cytoskeletal rearrangement, are involved in tumor progression in various cancer types. However, little is known about the roles of PFDNs in hepatocellular carcinoma (HCC).…
View article: WITHDRAWN: RNF125 attenuates hepatocellular carcinoma progression by downregulating SRSF1-ERK pathway
WITHDRAWN: RNF125 attenuates hepatocellular carcinoma progression by downregulating SRSF1-ERK pathway Open
Hepatocellular carcinoma (HCC) is one of the most deadly malignant cancers worldwide. Research into the crucial genes responsible for maintaining the aggressive behaviour of cancer cells is important for the clinical treatment of HCC. The …
View article: Key molecules associated with thyroid carcinoma prognosis: A study based on transcriptome sequencing and GEO datasets
Key molecules associated with thyroid carcinoma prognosis: A study based on transcriptome sequencing and GEO datasets Open
Background Thyroid carcinoma (THCA) has a low mortality rate, but its incidence has been rising over the years. We need to pay attention to its progression and prognosis. In this study, a transcriptome sequencing analysis and bioinformatic…
View article: Identification of CFHR4 as a Potential Prognosis Biomarker Associated With lmmune Infiltrates in Hepatocellular Carcinoma
Identification of CFHR4 as a Potential Prognosis Biomarker Associated With lmmune Infiltrates in Hepatocellular Carcinoma Open
Background Complement factor H-related 4 (CFHR4) is a protein-coding gene that plays an essential role in multiple diseases. However, the prognostic value of CFHR4 in hepatocellular carcinoma (HCC) is unknown. Methods Using multiple databa…