Michał Arabski
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View article: DNA damage response of U2OS cells to low doses of gamma radiation delivered at very low dose rate
DNA damage response of U2OS cells to low doses of gamma radiation delivered at very low dose rate Open
The DNA damage response (DDR) of cells to low dose and low dose rate ionizing radiation is weak and remains a matter of controversy. The response can be studied by exposing cells to a low adapting dose (AD) and, subsequently to a high chal…
View article: Exploiting gasdermin-mediated pyroptosis for enhanced antimicrobial activity of phage endolysin against <i>Pseudomonas aeruginosa</i>
Exploiting gasdermin-mediated pyroptosis for enhanced antimicrobial activity of phage endolysin against <i>Pseudomonas aeruginosa</i> Open
Pyroptosis is an inflammatory immune response of eukaryotic cells to bacterial lipopolysaccharide (LPS) and other pathological stimuli, leading to the activation of the gasdermin D (GSDMD) and secretion of pore-forming domain GSDMD Nterm ,…
View article: Syntheses, structures and biological activities of new pyridinyl lactones
Syntheses, structures and biological activities of new pyridinyl lactones Open
View article: Chitosan-based matrix as a carrier for bacteriophages
Chitosan-based matrix as a carrier for bacteriophages Open
View article: The impact of agarose immobilization on the activity of lytic Pseudomonas aeruginosa phages combined with chemicals
The impact of agarose immobilization on the activity of lytic Pseudomonas aeruginosa phages combined with chemicals Open
View article: The effect of surface modification of dendronized gold nanoparticles on activation and release of pyroptosis-inducing pro-inflammatory cytokines in presence of bacterial lipopolysaccharide in monocytes
The effect of surface modification of dendronized gold nanoparticles on activation and release of pyroptosis-inducing pro-inflammatory cytokines in presence of bacterial lipopolysaccharide in monocytes Open
Biomedical applications of gold nanoparticles (AuNPs) may be limited by their toxicological effects. Although surface-modified AuNPs can induce apoptosis, less is known about whether they can induce other types of cell death. Pyroptosis, a…
View article: The Antibacterial Effect of PEGylated Carbosilane Dendrimers on P. aeruginosa Alone and in Combination with Phage-Derived Endolysin
The Antibacterial Effect of PEGylated Carbosilane Dendrimers on P. aeruginosa Alone and in Combination with Phage-Derived Endolysin Open
The search for new microbicide compounds is of an urgent need, especially against difficult-to-eradicate biofilm-forming bacteria. One attractive option is the application of cationic multivalent dendrimers as antibacterials and also as ca…
View article: Biomedyczne właściwości chitozanu – zastosowanie w inżynierii tkankowej Biomedical properties of chitosan: Application in tissue engineering
Biomedyczne właściwości chitozanu – zastosowanie w inżynierii tkankowej Biomedical properties of chitosan: Application in tissue engineering Open
Abstrakt Inżynieria tkankowa to interdyscyplinarna dziedzina badań, która stosuje zasady inżynierii i nauk przyrodniczych do opracowywania substytutów biologicznych, przywracania, utrzymywania lub poprawy funkcji tkanek. Łączy medycy-nę kl…
View article: Emerging Phage Resistance in Pseudomonas aeruginosa PAO1 Is Accompanied by an Enhanced Heterogeneity and Reduced Virulence
Emerging Phage Resistance in Pseudomonas aeruginosa PAO1 Is Accompanied by an Enhanced Heterogeneity and Reduced Virulence Open
Bacterial surface structures of a proteinic nature and glycoconjugates contribute to biofilm formation and provide shields to host defense mechanisms (e.g., the complement system and phagocytosis). A loss or alteration of these molecules, …
View article: Subdiffusion equation with Caputo fractional derivative with respect to\n another function in modelling diffusion in a complex system consisting of\n matrix and channels
Subdiffusion equation with Caputo fractional derivative with respect to\n another function in modelling diffusion in a complex system consisting of\n matrix and channels Open
Diffusion equation with a fractional Caputo time derivative with respect to\nanother function $g$, which defines new time scale of the process, is applied\nto describe anomalous diffusion of antibiotic (colistin) in a system consisting\nof…
View article: Subdiffusion equation with Caputo fractional derivative with respect to another function in modelling diffusion in a complex system consisting of matrix and channels
Subdiffusion equation with Caputo fractional derivative with respect to another function in modelling diffusion in a complex system consisting of matrix and channels Open
Diffusion equation with a fractional Caputo time derivative with respect to another function $g$, which defines new time scale of the process, is applied to describe anomalous diffusion of antibiotic (colistin) in a system consisting of pa…
View article: Coralyne Radiosensitizes A549 Cells by Upregulation of CDKN1A Expression to Attenuate Radiation Induced G2/M Block of the Cell Cycle
Coralyne Radiosensitizes A549 Cells by Upregulation of CDKN1A Expression to Attenuate Radiation Induced G2/M Block of the Cell Cycle Open
Coralyne is a synthetic analog of berberine related to protoberberine-isoquinoline alkaloids. Isoquinoline derivatives and analogs are renowned as potent radiosensitizers with potential medical application. In the present study, we investi…
View article: New Approach to Antifungal Activity of Fluconazole Incorporated into the Porous 6-Anhydro-α-l-Galacto-β-d-Galactan Structures Modified with Nanohydroxyapatite for Chronic-Wound Treatments—In Vitro Evaluation
New Approach to Antifungal Activity of Fluconazole Incorporated into the Porous 6-Anhydro-α-l-Galacto-β-d-Galactan Structures Modified with Nanohydroxyapatite for Chronic-Wound Treatments—In Vitro Evaluation Open
New fluconazole-loaded, 6-Anhydro-α-l-Galacto-β-d-Galactan hydrogels incorporated with nanohydroxyapatite were prepared and their physicochemical features (XRD, X-ray Diffraction; SEM-EDS, Scanning Electron Microscopy-Energy Dispersive X-r…
View article: Experimental and Theoretical Analysis of Metal Complex Diffusion through Cell Monolayer
Experimental and Theoretical Analysis of Metal Complex Diffusion through Cell Monolayer Open
The study of drugs diffusion through different biological membranes constitutes an essential step in the development of new pharmaceuticals. In this study, the method based on the monolayer cell culture of CHO-K1 cells has been developed i…
View article: Rodzina białek gazdermin jako czynnik permeabilizujący błonę komórkową w procesie pyroptozy<sup>*</sup>
Rodzina białek gazdermin jako czynnik permeabilizujący błonę komórkową w procesie pyroptozy<sup>*</sup> Open
Streszczenie Rodzaj śmierci komórkowej, tj. apoptoza, autofagia, nekroza czy pyroptoza zależy od czynnika indukującego oraz fazy cyklu komórkowego. Główną rolę w odpowiedzi immunologicznej organizmu na mikroorganizmy odgrywa proces zwany p…
View article: Fatty Acid Methyl Esters of the Aerophytic Cave Alga Coccomyxa subglobosa as a Source for Biodiesel Production
Fatty Acid Methyl Esters of the Aerophytic Cave Alga Coccomyxa subglobosa as a Source for Biodiesel Production Open
The microscopic alga Coccomyxa subglobosa, collected from the Głowoniowa Nyża Cave (Tatra Mountains, Poland), is a source of fatty acids (FAs) that could be used for biodiesel production. FAs from subaerial algae have unlimited availabilit…
View article: Modelling experimentally measured of ciprofloxacin antibiotic diffusion in Pseudomonas aeruginosa biofilm formed in artificial sputum medium
Modelling experimentally measured of ciprofloxacin antibiotic diffusion in Pseudomonas aeruginosa biofilm formed in artificial sputum medium Open
We study the experimentally measured ciprofloxacin antibiotic diffusion through a gel-like artificial sputum medium (ASM) mimicking physiological conditions typical for a cystic fibrosis layer, in which regions occupied by Pseudomonas aeru…
View article: Antitumor Activity of Pt(II), Ru(III) and Cu(II) Complexes
Antitumor Activity of Pt(II), Ru(III) and Cu(II) Complexes Open
Metal complexes are currently potential therapeutic compounds. The acquisition of resistance by cancer cells or the effective elimination of cancer-affected cells necessitates a constant search for chemical compounds with specific biologic…
View article: Model of ciprofloxacin subdiffusion in<i>Pseudomonas aeruginosa</i>biofilm formed in artificial sputum medium
Model of ciprofloxacin subdiffusion in<i>Pseudomonas aeruginosa</i>biofilm formed in artificial sputum medium Open
We study theoretically and empirically ciprofioxacin antibiotic diffusion through a gel-like artificial sputum medium (ASM) mimicking physiological conditions typical for a cystic fibrosis layer, in which regions occupied by Pseudomonas ae…
View article: Dendronized Silver Nanoparticles as Bacterial Membrane Permeabilizers and Their Interactions With P. aeruginosa Lipopolysaccharides, Lysozymes, and Phage-Derived Endolysins
Dendronized Silver Nanoparticles as Bacterial Membrane Permeabilizers and Their Interactions With P. aeruginosa Lipopolysaccharides, Lysozymes, and Phage-Derived Endolysins Open
Antimicrobial proteins, like lysozymes produced by animals or bacteriophage lysins, enable the degradation of bacterial peptidoglycan (PG) and, consequently, lead to bacterial cell lysis. However, the activity of those enzymes is not satis…
View article: Plenary lectures
Plenary lectures Open
Experimental approaches to study electrostatic effects in biomolecular processes include investigation of their dependence on the ionic strength of the medium in which they occur.One interesting class of biomolecular processes subject to s…
View article: Pseudomonas aeruginosa PA5oct Jumbo Phage Impacts Planktonic and Biofilm Population and Reduces Its Host Virulence
Pseudomonas aeruginosa PA5oct Jumbo Phage Impacts Planktonic and Biofilm Population and Reduces Its Host Virulence Open
The emergence of phage-resistant mutants is a key aspect of lytic phages-bacteria interaction and the main driver for the co-evolution between both organisms. Here, we analyze the impact of PA5oct jumbo phage treatment on planktonic/cell l…
View article: Selective cytotoxicity and antifungal properties of copper(II) and cobalt(II) complexes with imidazole-4-acetate anion or 1-allylimidazole
Selective cytotoxicity and antifungal properties of copper(II) and cobalt(II) complexes with imidazole-4-acetate anion or 1-allylimidazole Open
View article: Ciprofloxacin, amoxicillin, and aminoglycosides stimulate genetic and phenotypic changes in uropathogenic <i>Escherichia coli</i> strains
Ciprofloxacin, amoxicillin, and aminoglycosides stimulate genetic and phenotypic changes in uropathogenic <i>Escherichia coli</i> strains Open
Antibiotic therapy and its consequences in bacterial and human aspects are widely investigated. Despite this, the emergence of new multidrug resistant bacteria is still a current problem. The scope of our work included the observation of c…
View article: The correlation of crystalline and elemental composition of urinary stones with a history of bacterial infections: TXRF, XRPD and PCR-DGGE studies
The correlation of crystalline and elemental composition of urinary stones with a history of bacterial infections: TXRF, XRPD and PCR-DGGE studies Open
The aim of this study was to analyze the correlation between past bacterial infections and the type and chemical composition of urinary stones experienced by human patients. Bacteria have been recognized to contribute to urinary stones; ho…
View article: <i>Pseudomonas aeruginosa</i> PA5oct jumbo phage impacts planktonic and biofilm population and reduces its host virulence
<i>Pseudomonas aeruginosa</i> PA5oct jumbo phage impacts planktonic and biofilm population and reduces its host virulence Open
Summary In this work we analyzed the impact of jumbo phage PA5oct on the planktonic, cell line adhered, and biofilm population of P. aeruginosa . PA5oct has a broad host-range, able to infect up to 40% of our clinical P. aeruginosa Cystic …
View article: The O-specific polysaccharide lyase from the phage LKA1 tailspike reduces Pseudomonas virulence
The O-specific polysaccharide lyase from the phage LKA1 tailspike reduces Pseudomonas virulence Open
View article: A proposed integrated approach for the preclinical evaluation of phage therapy in Pseudomonas infections
A proposed integrated approach for the preclinical evaluation of phage therapy in Pseudomonas infections Open
View article: Searching for in vitro biomarkers of susceptibility to prostate and cervical cancers by analysis of chromosomal instability, γ-H2AX foci, polymorphisms in DNA repair genes and apoptosis
Searching for in vitro biomarkers of susceptibility to prostate and cervical cancers by analysis of chromosomal instability, γ-H2AX foci, polymorphisms in DNA repair genes and apoptosis Open
1. Hagmar L, Bonassi S, Strömberg U, Mikoczy Z, Lando C, Hansteen I-L, Montagud AH, Knudsen L, Norppa H, Reuterwall Ch, Tinnerberg H, Brøgger A, Forni A, Högstedt B, Lambert B, Mitelman F, Nordenson I, Salomaa S, Skerfving S. Canser predic…
View article: Correction: Characterization of the Newly Isolated Lytic Bacteriophages KTN6 and KT28 and Their Efficacy against Pseudomonas aeruginosa Biofilm
Correction: Characterization of the Newly Isolated Lytic Bacteriophages KTN6 and KT28 and Their Efficacy against Pseudomonas aeruginosa Biofilm Open