Micha T. Maeder
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View article: Reply to letter to the editor
Reply to letter to the editor Open
View article: Sleep apnea is associated with reduced in-hospital mortality in patients admitted for acute heart disease
Sleep apnea is associated with reduced in-hospital mortality in patients admitted for acute heart disease Open
Background: Sleep apnea (SA) is an independent risk factor for many cardiovascular diseases. The impact of SA on the outcome of patients hospitalized due to cardiovascular diseases is controversial. Recent studies indicated fewer fatal car…
View article: Impact of left ventricular ejection fraction on the effect of beta-blocker therapy on 1-year mortality in acute coronary syndrome patients
Impact of left ventricular ejection fraction on the effect of beta-blocker therapy on 1-year mortality in acute coronary syndrome patients Open
Aims While the beneficial effect of beta-blocker (BB) therapy for acute coronary syndrome (ACS) patients with a left ventricular ejection fraction (LVEF) of 40% is established, its role in those with LVEF > 40% is controversial. We asse…
View article: The pulmonary artery pulsatility index in patients with severe aortic stenosis undergoing valve replacement
The pulmonary artery pulsatility index in patients with severe aortic stenosis undergoing valve replacement Open
Background and aims The pulmonary artery pulsatility index (PAPi), that is, the pulmonary artery pulse pressure (PAPP) divided by the mean right atrial pressure (mRAP), is an increasingly used invasive index of right ventricular function. …
View article: A case report of reversible left ventricular dysfunction due to azathioprine hypersensitivity syndrome
A case report of reversible left ventricular dysfunction due to azathioprine hypersensitivity syndrome Open
Background Hypersensitivity reaction is a rare side effect during immunosuppressive treatment with azathioprine (AZA). Some cases of cardiac involvement have already been reported but causality is notoriously difficult to prove. Case summa…
View article: Quantifying Hemodynamic Cardiac Stress and Cardiomyocyte Injury in Normotensive and Hypertensive Acute Heart Failure
Quantifying Hemodynamic Cardiac Stress and Cardiomyocyte Injury in Normotensive and Hypertensive Acute Heart Failure Open
Background: The characterization of the different pathophysiological mechanisms involved in normotensive versus hypertensive acute heart failure (AHF) might help to develop individualized treatments. Methods: The extent of hemodynamic card…
View article: Impact of the 2022 pulmonary hypertension definition on haemodynamic classification and mortality in patients with aortic stenosis undergoing valve replacement
Impact of the 2022 pulmonary hypertension definition on haemodynamic classification and mortality in patients with aortic stenosis undergoing valve replacement Open
Aims With the 2022 pulmonary hypertension (PH) definition, the mean pulmonary artery pressure (mPAP) threshold for any PH was lowered from ≥25 to >20 mmHg, and the pulmonary vascular resistance (PVR) value to differentiate between isola…
View article: Pleural effusion in severe aortic stenosis: marker of an adverse haemodynamic constellation and poor prognosis
Pleural effusion in severe aortic stenosis: marker of an adverse haemodynamic constellation and poor prognosis Open
Aim Pleural effusion (PE) is a common chest radiography (CXR) finding in patients with advanced cardiac disease. The pathophysiology and clinical value of PE in this setting are incompletely defined. We aimed to assess the haemodynamic cor…
View article: THU248 Screening For Heart Failure In Patients With Diabetes Mellitus - A SwissDiab Study
THU248 Screening For Heart Failure In Patients With Diabetes Mellitus - A SwissDiab Study Open
Disclosure: M. Brandle: None. L. Knaus: None. M. Quarella: None. M. Maeder: None. M. Buser: None. F. Renstrom: None. Sodium-glucose co-transporter 2 inhibitors (SGLT2i) have been shown to significantly reduce the risk of hospitalization fo…
View article: ECG left ventricular hypertrophy in aortic stenosis: Relationship with cardiac structure, invasive hemodynamics, and long‐term mortality
ECG left ventricular hypertrophy in aortic stenosis: Relationship with cardiac structure, invasive hemodynamics, and long‐term mortality Open
Background In aortic stenosis (AS), left ventricular hypertrophy (LVH) is the response to pressure overload and represents the substrate for a maladaptive cascade, the so‐called AS‐related cardiac damage. We hypothesized that in AS patient…
View article: Pulmonary Congestion by Conventional Chest Radiography: Relationship With Hemodynamics and Mortality in Patients With Severe Aortic Stenosis
Pulmonary Congestion by Conventional Chest Radiography: Relationship With Hemodynamics and Mortality in Patients With Severe Aortic Stenosis Open
View article: How to Assess Bleeding Risk in Patients Undergoing Percutaneous Coronary Interventions
How to Assess Bleeding Risk in Patients Undergoing Percutaneous Coronary Interventions Open
A relevant proportion of patients undergoing percutaneous coronary intervention (PCI) have a high risk of bleeding.The associated individual risk of ischaemia can be differentiated by an app-based approach and helps to determine the durati…
View article: Gender-specific disease trajectories prior to the onset of COPD allow individualized screening and early intervention
Gender-specific disease trajectories prior to the onset of COPD allow individualized screening and early intervention Open
Background Nation-wide hospitalization databases include diagnostic information at the level of an entire population over an extended period of time. Comorbidity network and early disease development can be unveiled. Chronic obstructive pu…
View article: Editorial: Novel methodologies in structural interventional cardiology: Case reports
Editorial: Novel methodologies in structural interventional cardiology: Case reports Open
EDITORIAL article Front. Cardiovasc. Med., 12 April 2023Sec. Structural Interventional Cardiology Volume 10 - 2023 | https://doi.org/10.3389/fcvm.2023.1191819
View article: Estimated glomerular filtration rate, haemodynamics, and mortality in patients with aortic stenosis
Estimated glomerular filtration rate, haemodynamics, and mortality in patients with aortic stenosis Open
Background In aortic stenosis (AS), estimated glomerular filtration rate (eGFR) is an important prognostic marker but its haemodynamic determinants are unknown. We investigated the correlation between eGFR and invasive haemodynamics and lo…
View article: Diagnosing heart failure with preserved ejection fraction with pulmonary vascular disease
Diagnosing heart failure with preserved ejection fraction with pulmonary vascular disease Open
View article: Systemic blood pressure in severe aortic stenosis: Haemodynamic correlates and long‐term prognostic impact
Systemic blood pressure in severe aortic stenosis: Haemodynamic correlates and long‐term prognostic impact Open
Aims Blood pressure (BP) targets in patients with aortic stenosis (AS) are controversial. This study sought to describe the haemodynamic profile and the clinical outcome of severe AS patients with low versus high central meaarterial pressu…
View article: Treatment and outcome of patients with acute myocardial infarction and chronic lung disease: insights from the nationwide AMIS Plus registry
Treatment and outcome of patients with acute myocardial infarction and chronic lung disease: insights from the nationwide AMIS Plus registry Open
Introduction Little is known about patients with acute myocardial infarction (AMI) and chronic lung disease (CLD). The aim of our study was to analyze risk factors, treatment, and outcome of AMI patients with CLD over the last 20 years usi…
View article: Detrimental effects of intense vasodilation in women with acute heart failure: novel insights from a prospective randomized controlled trial
Detrimental effects of intense vasodilation in women with acute heart failure: novel insights from a prospective randomized controlled trial Open
Background Guidelines recommend evaluating the risk/benefit ratio of novel therapies individually in women and men, as the pathophysiology and the response to treatment may differ according to sex. Among patients with acute heart failure (…
View article: Budget Impact of Intravenous Iron Therapy with Ferric Carboxymaltose in Patients with Chronic Heart Failure with Reduced Ejection Fraction (HFrEF) and Iron Deficiency in Switzerland
Budget Impact of Intravenous Iron Therapy with Ferric Carboxymaltose in Patients with Chronic Heart Failure with Reduced Ejection Fraction (HFrEF) and Iron Deficiency in Switzerland Open
The present analysis shows that using FCM to treat HFrEF patients with ID in line with current guideline recommendations resulted not only in medical benefits but also in significant cost savings. The analysis also provides an example of t…
View article: Therapie der Herzinsuffizienz mit reduzierter Auswurffraktion: Was ist neu in den Leitlinien 2021?
Therapie der Herzinsuffizienz mit reduzierter Auswurffraktion: Was ist neu in den Leitlinien 2021? Open
Zusammenfassung. Das Spektrum der Optionen zur Behandlung der Herzinsuffizienz mit reduzierter Auswurffraktion (Heart Failure with reduced Ejection Fraction, HFrEF) hat sich in den vergangenen Jahren deutlich erweitert. Die nun publizierte…
View article: SGTL-2 Inhibitors and Heart Failure
SGTL-2 Inhibitors and Heart Failure Open
The sodium-glucose co-transporter 2 inhibitors have become an integral part of the treatment of patients with high cardiovascular risk or established cardiovascular disease. In the present review, we summarise the available data from precl…
View article: Long-term follow-up of medically treated patients with spontaneous coronary artery dissection: a prospective, Swiss single-centre cohort study
Long-term follow-up of medically treated patients with spontaneous coronary artery dissection: a prospective, Swiss single-centre cohort study Open
AIMS OF THE STUDY: Spontaneous coronary artery dissection (SCAD) is an increasingly diagnosed cause of acute myocardial infarction. However, there is still a limited number of larger cohorts with long-term follow-up. We report on the large…
View article: Selexipag and the pulmonary hypertension continuum
Selexipag and the pulmonary hypertension continuum Open
This article refers to 'The impact of comorbidities on selexipag treatment effect in patients with pulmonary arterial hypertension: insights from the GRIPHON study' by S. Rosenkranz et al., published in this issue on pages 205–214. Theoret…
View article: Discordance in prognostic ability between physician assessed NYHA classification and self-reported health status in patients with acute heart failure
Discordance in prognostic ability between physician assessed NYHA classification and self-reported health status in patients with acute heart failure Open
Background Especially in patients with acute heart failure (AHF) the NYHA classification remains of uncertain representation of patients' actual health state. Alternatively, patient's subjective well-being, in terms of health-related quali…
View article: Hemodynamics Prior to Valve Replacement for Severe Aortic Stenosis and Pulmonary Hypertension during Long-Term Follow-Up
Hemodynamics Prior to Valve Replacement for Severe Aortic Stenosis and Pulmonary Hypertension during Long-Term Follow-Up Open
(1) Background: Pulmonary hypertension after aortic valve replacement (AVR; post-AVR PH) carries a poor prognosis. We assessed the pre-AVR hemodynamic characteristics of patients with versus without post-AVR PH. (2) Methods: We studied 205…
View article: Effect of a strategy of comprehensive vasodilation versus usual care on health‐related quality of life among patients with acute heart failure
Effect of a strategy of comprehensive vasodilation versus usual care on health‐related quality of life among patients with acute heart failure Open
Aims We aimed to assess the long‐term effect of a strategy of comprehensive vasodilation versus usual care on health‐related quality of life (HRQL) among patients with acute heart failure (AHF). Methods and results Health‐related quality o…
View article: Wedge Pressure vs Left Ventricular End-Diastolic Pressure for Pulmonary Hypertension Classification and Prognostication in Severe Aortic Stenosis
Wedge Pressure vs Left Ventricular End-Diastolic Pressure for Pulmonary Hypertension Classification and Prognostication in Severe Aortic Stenosis Open
View article: Pulmonary Hypertension in Patients With Heart Failure With Mid-Range Ejection Fraction
Pulmonary Hypertension in Patients With Heart Failure With Mid-Range Ejection Fraction Open
Pulmonary hypertension (PH) is common in patients with heart failure (HF). The role of PH in patients with HF with reduced (HFrEF) and preserved (HFpEF) left ventricular ejection fraction (LVEF) has been extensively characterized during th…
View article: Impact of the new pulmonary hypertension definition on <scp>long‐term</scp> mortality in patients with severe aortic stenosis undergoing valve replacement
Impact of the new pulmonary hypertension definition on <span>long‐term</span> mortality in patients with severe aortic stenosis undergoing valve replacement Open
Background The new 2018 pulmonary hypertension (PH) definition includes a lower mean pulmonary artery pressure (mPAP) cut‐off (>20 mmHg rather than ≥25 mmHg) and the compulsory requirement of a pulmonary vascular resistance (PVR) ≥3 Wood u…