Explanipedia

Doing gender and the surname choices of married women Open

Florencia Torche, Arthur M. Feldman, Tyler McDaniel · 2025

Marital surname choices reflect deeply embedded, often unspoken gender norms. According to the marital exchange/bargaining approach, women are more likely to adopt their husband’s surname when they hold lower status—measured by education o…

Rare variants in cardiomyopathy genes predispose to cardiac injury in severe COVID-19 patients of African or Hispanic ancestry Open

Hui‐Qi Qu, Matthew S. Delfiner, Chethan Gangireddy, Anjali Vaidya, Kenny Nguyen , et al. · 2024

The Role of BAG3 Protein Interactions in Cardiomyopathies Open

Hui‐Qi Qu, Jufang Wang, Alexandre Rosa-Campos, Hákon Hákonarson, Arthur M. Feldman · 2024

Bcl-2-associated athanogene 3 (BAG3) plays an important function in cellular protein quality control (PQC) maintaining proteome stability. Mutations in the BAG3 gene result in cardiomyopathies. Due to its roles in cardiomyopathies and the …

THE FORMATION OF WINSTON CHURCHILL'S GERMANOPHOBIC VIEWS IN THE 1880S AND 1890S. Open

Arthur M. Feldman · 2024

The article examines the process of formation of Sir Winston Churchill's Germanophobic views in the 1880s-1890s. The British Prime Minister is known as an eccentric man not so much in his actions as in his statements. This became the basis…

Dysregulated Autophagy and Sarcomere Dysfunction in Patients With Heart Failure With Co‐Occurrence of P63A and P380S BAG3 Variants Open

Thomas G. Martin, H N Pak, Glenn S. Gerhard, Salim Merali, Carmen Merali , et al. · 2023

Background Mutations to the co‐chaperone protein BAG3 (B‐cell lymphoma‐2–associated athanogene‐3) are a leading cause of dilated cardiomyopathy (DCM). These mutations often impact the C‐terminal BAG domain (residues 420–499), which regulat…

Bag3 Regulates Mitochondrial Function and the Inflammasome Through Canonical and Noncanonical Pathways in the Heart Open

JuFang Wang, Dhanendra Tomar, Thomas G. Martin, Shubham Dubey, Praveen Kumar Dubey , et al. · 2023

B-cell lymphoma 2-associated athanogene-3 (Bag3) is expressed in all animal species, with Bag3 levels being most prominent in the heart, the skeletal muscle, the central nervous system, and in many cancers. Preclinical studies of Bag3 biol…

Precision Medicine Open

Arthur M. Feldman, Edward K. Kasper, Hui‐Qi Qu · 2023

BAG3: Nature’s Quintessential Multi-Functional Protein Functions as a Ubiquitous Intra-Cellular Glue Open

Caitlyn M. Brenner, Muaaz Choudhary, Michael G. McCormick, David W. Cheung, Gavin Landesberg , et al. · 2023

BAG3 is a 575 amino acid protein that is found throughout the animal kingdom and homologs have been identified in plants. The protein is expressed ubiquitously but is most prominent in cardiac muscle, skeletal muscle, the brain and in many…

Genetics of BAG3: A Paradigm for Developing Precision Therapies for Dilated Cardiomyopathies Open

Hui‐Qi Qu, Arthur M. Feldman, Hákon Hákonarson · 2022

Nonischemic dilated cardiomyopathy is a common form of heart muscle disease in which genetic factors play a critical etiological role. In this regard, both rare disease‐causing mutations and common disease‐susceptible variants, in the Bcl‐…

Cardiac Transduction in Mini-Pigs After Low-Dose Retrograde Coronary Sinus Infusion of AAV9-BAG3 Open

Valerie D. Myers, BS Gavin P. Landesberg, BA Marcia L. Bologna, Marc J. Semigran, Arthur M. Feldman · 2022

The effect of cardiac resynchronization without a defibrillator on morbidity and mortality: an individual patient data meta‐analysis of COMPANION and CARE‐HF Open

John G.F. Cleland, Michael R. Bristow, Nicholas Freemantle, Brian Olshansky, Daniel Gras , et al. · 2022

Aims Cardiac resynchronization therapy (CRT) reduces morbidity and mortality for patients with heart failure, reduced left ventricular ejection fraction, QRS duration >130 ms and in sinus rhythm. The aim of this study was to identify patie…

Therapeutic targeting of BAG3: considering its complexity in cancer and heart disease Open

Jonathan A. Kirk, Joseph Y. Cheung, Arthur M. Feldman · 2021

Bcl2-associated athanogene-3 (BAG3) is expressed ubiquitously in humans, but its levels are highest in the heart, the skeletal muscle, and the central nervous system; it is also elevated in many cancers. BAG3's diverse functions are suppor…

Cardiomyocyte contractile impairment in heart failure results from reduced BAG3-mediated sarcomeric protein turnover Open

Thomas G. Martin, Valerie D. Myers, Praveen Kumar Dubey, Shubham Dubey, Edith Perez , et al. · 2021

The Addition of a Defibrillator to Resynchronization Therapy Decreases Mortality in Patients With Nonischemic Cardiomyopathy Open

Bethany Doran, Chaoqun Mei, Paul D. Varosy, David Kao, Leslie A. Saxon , et al. · 2021

COMPANION patients with NICM exhibited a decrease in ACM associated with CRT-D but not CRT-P treatment, whereas patients with ICM did not.

Unsupervised Region-Based Anomaly Detection In Brain MRI With Adversarial Image Inpainting Open

Bao T. Nguyen, Arthur M. Feldman, Sarath Bethapudi, Andrew Jennings, Chris G. Willcocks · 2021

Medical segmentation is performed to determine the bounds of regions of interest (ROI) prior to surgery. By allowing the study of growth, structure, and behaviour of the ROI in the planning phase, critical information can be obtained, incr…

Table of Contents Open

Vaughn A. Starnes, Los Ángeles, Craig R. Smith, New York, Tirone E. David , et al. · 2021

Novel BAG3 Variants in African American Patients With Cardiomyopathy: Reduced β-Adrenergic Responsiveness in Excitation–Contraction Open

Arthur M. Feldman, Jennifer Gordon, Jufang Wang, Jianliang Song, Xue-Qian Zhang , et al. · 2020

Sudden Cardiac Death in Patients With Ischemic Heart Failure Undergoing Coronary Artery Bypass Grafting: Results From the STICH Randomized Clinical Trial (Surgical Treatment for Ischemic Heart Failure). Open

Meena P. Rao, Sana M. Al‐Khatib, Sean D. Pokorney, Lilin She, Alexander Romanov , et al. · 2020

BACKGROUND: The risk of sudden cardiac death (SCD) in patients with heart failure after coronary artery bypass graft surgery (CABG) has not been examined in a contemporary clinical trial of surgical revascularization. This analysis describ…

Cardiomyocyte Contractile Impairment in Heart Failure Results from Reduced BAG3-mediated Sarcomeric Protein Turnover Open

Thomas G. Martin, Valerie D. Myers, Praveen Kumar Dubey, Shubham Dubey, Edith Perez , et al. · 2020

The association between reduced myofilament force-generating capacity (F max ) and heart failure (HF) is clear, however the underlying molecular mechanisms are poorly understood. Here, we show the F max decrease arises from impaired BAG3-m…

Restoring public trust in scientific research by reducing conflicts of interest Open

Arthur M. Feldman, Douglas L. Mann · 2019

ACC/AHA 2005 Guideline Update for the Diagnosis and Management of Chronic Heart Failure in the Adult: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Update the 2001 Guidelines for the Evaluation and Management of Heart Failure) Open

Sharon A. Hunt, William T. Abraham, Marshall H. Chin, Arthur M. Feldman, Gary S. Francis , et al. · 2019

"The committee elected to focus this document on the prevention of HF and on the diagnosis and management of chronic HF in the adult patient with normal or low LVEF. It specifically did not consider acute HF, which might merit a separate s…

S5A-01 SESSION 5A: GENERALITIES IN CRANIOSYNOSTOSIS – PART II EVALUATING STRESS IN CAREGIVERS OF CHILDREN WITH CRANIOSYNOSTOSIS Open

Alan R. Tang, Georgina E. Sellyn, Arthur M. Feldman, C. Havemann, Stephen R. Gannon , et al. · 2019

Introduction: Caregiver stress brought on by a child’s diagnosis impacts a caregiver’s ability to participate in treatment decisions, comply and manage an illness long-term. In this study, we aim to identify baseline stress levels in careg…

To Breastfeed or Not to Breastfeed With Peripartum Cardiomyopathy Open

Zoltàn Arany, Arthur M. Feldman · 2019

Role of Bcl2-associated Athanogene 3 in Turnover of Gap Junction Protein, Connexin 43, in Neonatal Cardiomyocytes Open

Farzaneh G. Tahrir, Manish Gupta, Valerie D. Myers, Jennifer Gordon, Joseph Y. Cheung , et al. · 2019

Any pathological stress that impairs expression, turnover and phosphorylation of connexin 43 (Cx43), one of the major proteins of gap junctions, can adversely impact myocardial cell behavior, thus leading to the development of cardiac arrh…

Current Landscape of Heart Failure Gene Therapy Open

Jake Kieserman, Valerie D. Myers, Praveen Kumar Dubey, Joseph Y. Cheung, Arthur M. Feldman · 2019

Lysosomal acid lipase deficiency – early diagnosis is the key Open

Georg Strebinger, Erich Müller, Arthur M. Feldman, Elmar Aigner · 2019

Georg Strebinger, Elena Müller, Alexandra Feldman, Elmar AignerFirst Department of Medicine, Paracelsus Medical University, Salzburg, AustriaAbstract: Lysosomal acid lipase deficiency (LAL-D) is an ultra-rare lysosomal storage disease that…

Adrenergic Polymorphisms and Survival in African Americans With Heart Failure: Results From A-HeFT Open

Amber E. Johnson, Karen Hanley‐Yanez, Clyde W. Yancy, Anne L. Taylor, Arthur M. Feldman , et al. · 2019

Evidence for the impact of BAG3 on electrophysiological activity of primary culture of neonatal cardiomyocytes Open

Farzaneh G. Tahrir, Jennifer Gordon, Arthur M. Feldman, Joseph Y. Cheung, Kamel Khalili , et al. · 2019

Homeostasis of proteins involved in contractility of individual cardiomyocytes and those coupling adjacent cells is of critical importance as any abnormalities in cardiac electrical conduction may result in cardiac irregular activity and h…

Trpm2 enhances physiological bioenergetics and protects against pathological oxidative cardiac injury: Role of Pyk2 phosphorylation Open

Barbara A. Miller, JuFang Wang, Jianliang Song, Xue‐Qian Zhang, Iwona Hirschler‐Laszkiewicz , et al. · 2019

The mechanisms by which Trpm2 channels enhance mitochondrial bioenergetics and protect against oxidative stress‐induced cardiac injury remain unclear. Here, the role of proline‐rich tyrosine kinase 2 (Pyk2) in Trpm2 signaling is explored. …

Lamin B is a target for selective nuclear PQC by BAG3: implication for nuclear envelopathies Open

Manish Gupta, Jennifer Gordon, Gregory Glauser, Valerie D. Myers, Arthur M. Feldman , et al. · 2019

Nuclear envelopathies are recognized genetic disorders affecting individuals with mutations in their genes encoding members of the lamin family of nuclear envelope proteins that are responsible for maintaining the architectural structure o…

Arthur M. Feldman YOU? Author Swipe