Explanipedia

Infection-sensing minigenome as a novel therapeutic approach against Ebola virus Open

Lin Wang, Brady N. Zell, Brian J. Parrett, Michael A. Barry, Satoko Yamaoka · 2025

PERSISTENT EXPRESSION OF CHITINASE 3-LIKE 1 IN EX VIVO-MAINTAINED GLIOBLASTOMA BIOPSIES DESPITE CHEMOTHERAPY: IMPLICATIONS FOR IMMUNE EVASION Open

Amr M. Moursi, Michael A. Barry, Ian Scott, Shailendra Achawal, Chittoor Rajaraman , et al. · 2025

AIMS Background: Glioblastoma (GBM) remains a highly aggressive and treatment-resistant brain tumour, characterized by pro- found immune suppression. Chitinase 3-like 1 (CHI3L1), a cytokine implicated in tumour progression and im- mune mod…

AAV9-mediated KCNH2 suppression-replacement gene therapy in a transgenic rabbit model of type 1 short QT syndrome Open

Saranda Nimani, Sahej Bains, Nicolò Alerni, Balázs Ördög, András Horváth , et al. · 2025

Background and Aims Type 1 short QT syndrome (SQT1) is a genetic channelopathy caused by gain-of-function variants in KCNH2, resulting in shortened cardiac repolarization and QT intervals, which predispose patients to ventricular arrhythmi…

Synaptic and intrinsic plasticity mediated by CCK-type signaling coordinates behavioral changes during motivational state shifts Open

Guo Zhang, Xueying Ding, Elena V. Romanova, Cuiping Liu, Michael A. Barry , et al. · 2025

Induced Proteinuria Enhances Adeno-Associated Virus Transduction of Renal Tubule Epithelial Cells After Intravenous Administration Open

Jeffrey D. Rubin, Katayoun Ayasoufi, Erin B. McGlinch, Michael J. Hansen, Peter C. Harris , et al. · 2025

A variety of genetic diseases of the kidney tubule are amenable to correction via gene therapy. However, gene delivery to renal tubule epithelial cells mediated by viral vectors via the blood is inefficient due to the permselectivity of th…

Development of a Pentacistronic Ebola Virus Minigenome System Open

Brady N. Zell, Vaille A. Swenson, Shao‐Chia Lu, Lin Wang, Michael A. Barry , et al. · 2025

Ebola virus (EBOV) causes severe disease outbreaks in humans with high case fatality rates. EBOV requires adaptation to cause lethal disease in mice by acquiring single mutations in both the nucleoprotein (NP) and VP24 genes. As an attempt…

Convergent effects of peptides on the initiation of feeding motor programs in the mollusk Aplysia Open

Colin G. Evans, Michael A. Barry, Carrie N. Reaver, Paras R. Patel, Cynthia A. Chestek , et al. · 2025

The activity of most networks is affected by multiple neuromodulators. Studies that have sought to determine why this is the case have focused on how the effects of one modulator differ from those of another (how modulators uniquely determ…

ACE2 deficiency protects against heme protein-induced acute kidney injury Open

Anthony J. Croatt, Raman Deep Singh, Joseph P. Grande, Allan W. Ackerman, Susan B. Gurley , et al. · 2025

ACE2 protein binds heme, which we reasoned would promote heme entry into the kidney and, accordingly, heme protein-mediated acute kidney injury. Our findings support this hypothesis. This study is the first to demonstrate the biological re…

Reducing off-target expression of mRNA therapeutics and vaccines in the liver with microRNA binding sites Open

Brian J. Parrett, Satoko Yamaoka, Michael A. Barry · 2024

Lipid nanoparticles (LNPs) are often liver tropic, presenting challenges for LNP-delivered mRNA therapeutics intended for other tissues, as off-target expression in the liver may increase side effects and modulate immune responses. To avoi…

Renal phenotyping in a hypomorphic murine model of propionic aciduria reveals common pathomechanisms in organic acidurias Open

Anke Schumann, Ainhoa Martínez‐Pizarro, Eva Richard, Christoph Schell, Anna Laura Kössinger , et al. · 2024

Mutations in the mitochondrial enzyme propionyl-CoA carboxylase (PCC) cause propionic aciduria (PA). Chronic kidney disease (CKD) is a known long-term complication. However, good metabolic control and standard therapy fail to prevent CKD. …

Development of a Pentacistronic Ebola Virus Minigenome and Its Application to Model Mouse-Adapted Ebola Virus Open

Brady N. Zell, Vaille A. Swenson, Shao‐Chia Lu, Lin Wang, Michael A. Barry , et al. · 2024

Ebola virus (EBOV) causes hemorrhagic disease in humans with high case fatality rates. EBOV requires adaptation to cause lethal disease in mice by acquiring single mutations in both the nucleoprotein (NP) and VP24 genes. The role(s) of the…

Structure-derived insights from blood factors binding to the surfaces of different adenoviruses Open

Haley Mudrick, Shao‐Chia Lu, Janarjan Bhandari, Mary E. Barry, Jack R. Hemsath , et al. · 2024

FastAd: A versatile toolkit for rapid generation of single adenoviruses or diverse adenoviral vector libraries Open

Shao‐Chia Lu, Yi-Yuan Lee, Felix G M Andres, Devlin C. Moyer, Michael A. Barry · 2024

Intranasal Prime–Boost with Spike Vectors Generates Antibody and T-Cell Responses at the Site of SARS-CoV-2 Infection Open

Muriel Metko, Jason M. Tonne, Aleta Rios, Jill Thompson, Haley Mudrick , et al. · 2024

Background: Long-lived, re-activatable immunity to SARS-CoV-2 and its emerging variants will rely on T cells recognizing conserved regions of viral proteins across strains. Heterologous prime–boost regimens can elicit elevated levels of ci…

Novel mechanism of inflammatory activation by Ebola virus matrix protein linked to the ebolavirus virulence Open

Satoko Yamaoka, Zeineb Mhamdi, Lin Wang, Vaille A. Swenson, Kristin L. McNally , et al. · 2024

Uncontrolled systemic inflammatory responses are a critical pathological feature of fatal Ebola virus (EBOV) infection. While some inflammatory responses may originate from mononuclear phagocytes (MNPs), non-immune cells vastly outnumber M…

KCNQ1 suppression-replacement gene therapy in transgenic rabbits with type 1 long QT syndrome Open

Sahej Bains, Lucilla Giammarino, Saranda Nimani, Nicolò Alerni, David J. Tester , et al. · 2024

Background and Aims Type 1 long QT syndrome (LQT1) is caused by pathogenic variants in the KCNQ1-encoded Kv7.1 potassium channels, which pathologically prolong ventricular action potential duration (APD). Herein, the pathologic phenotype i…

Adeno‐associated virus‐9 reverses delayed gastric emptying of solids in diabetic mice Open

Xiaojie Li, Sihan Ji, Gianluca Cipriani, Matthew L. Hillestad, Seth T. Eisenman , et al. · 2023

Background Gastroparesis is defined by delayed gastric emptying (GE) without obstruction. Studies suggest targeting heme oxygenase‐1 (HO1) may ameliorate diabetic gastroparesis. Upregulation of HO1 expression via interleukin‐10 (IL‐10) in …

Variable task switching in the feeding network of Aplysia is a function of differential command input Open

Colin G. Evans, Michael A. Barry, Matthew H. Perkins, Jian Jing, Klaudiusz R. Weiss , et al. · 2023

We study a type of motor program that can be induced either by stimulating a higher-order projection neuron that induces a persistent state, or by coactivating projection neurons that configure activity but do not produce a state change. W…

In vivo KCNQ1-suppression-replacement gene therapy in transgenic rabbits with type 1 long QT syndrome Open

Lucilla Giammarino, Saranda Nimani, Sarina Bains, Nicolò Alerni, David J. Tester , et al. · 2023

Funding Acknowledgements Type of funding sources: Private company. Main funding source(s): Pfizer Background Type 1 long QT syndrome (LQT1) is a genetic channelopathy characterized by both haploinsufficient and dominant-negative loss-of-fu…

Humanitarian Assistance Lessons Learned From Providing Acute Medical Care for Afghan Nationals on a U.S. Military Base Open

Eric J Koch, Tyler Lopachin, Zane Fayos, Timothy Lynch, Adrian Korduba , et al. · 2023

Operation Allies Welcome provided a unique opportunity for military medical personnel to engage in humanitarian assistance operations on military bases in the USA. With thousands of Afghan nationals evacuated from Kabul in August 2021 to v…

PO-02-210 AAV9-MEDIATED -SUPPRESSION-REPLACEMENT GENE THERAPY IN TRANSGENIC RABBITS WITH TYPE 1 LONG QT SYNDROME Open

Sahej Bains, Lucilla Giammarino, Saranda Nimani, Nicolò Alerni, David J. Tester , et al. · 2023

Supplementary Figure Legend from Species D Adenoviruses as Oncolytics against B-cell Cancers Open