Michael A. Cantrell
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CAR T cell therapy referral patterns and characteristics of patients with relapsed or refractory (R/R) large B cell lymphoma (LBCL) in the United States Open
Introduction: CAR T cell therapies are a pivotal advancement in the treatment of R/R LBCL that offer the potential for long-lasting deep remissions. However, real-world access to CAR T cell therapy remains fragmented, with systemic and log…
View article: Real-world survival analysis by tumor mutational burden in non-small cell lung cancer: a multisite U.S. study
Real-world survival analysis by tumor mutational burden in non-small cell lung cancer: a multisite U.S. study Open
TMB levels greater than or equal to 10 mut/Mb, when tested by Foundation Medicine or Caris at treatment initiation, were significantly associated with improved OS and PFS among patients treated with first-line immunotherapy-containing regi…
View article: Pan-cancer organoid validation of tumor outlier chromosomal amplification events
Pan-cancer organoid validation of tumor outlier chromosomal amplification events Open
SUMMARY Somatic copy number gains are pervasive in many cancer types, yet their roles in oncogenesis are often poorly explored. This lack of understanding is in part due to broad extensions of copy gains across cancer genomes spanning larg…
c-Jun N-terminal kinase 2 prevents luminal cell commitment in normal mammary glands and tumors by inhibiting <i>p53/Notch1</i> and <i>breast cancer gene 1</i> expression Open
Breast cancer is a heterogeneous disease with several subtypes carrying unique prognoses. Patients with differentiated luminal tumors experience better outcomes, while effective treatments are unavailable for poorly differentiated tumors, …
Observations of the Copenhagen Networks Study Open
Attribute-rich longitudinal datasets of any kind are extremely rare. In 2012 and 2013, the SensibleDTU project created such a dataset using approximately 1,000 university students. Since then, a large number of studies have been performed …
Asymptotic shapes for ergodic families of metrics on Nilpotent groups Open
Let Gamma be a finitely generated nilpotent group. We consider three closely related problems: (i) the asymptotic cone for an equivariant ergodic family of inner metrics on Gamma, generalizing Pansu's theorem; (ii) the limit shapes for Fir…
Differentiability of integrable measurable cocycles between nilpotent groups Open
We prove an analog for integrable measurable cocycles of Pansu’s differentiation theorem for Lipschitz maps between Carnot–Carathéodory spaces. This yields an alternative, ergodic theoretic proof of Pansu’s quasi-isometric rigidity theorem…