Michael A. Carlock
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View article: Assessing factors associated with one-year antibody waning in participants with repeated influenza vaccinations: A six-year cohort study
Assessing factors associated with one-year antibody waning in participants with repeated influenza vaccinations: A six-year cohort study Open
This study highlights multiple factors, including age, BMI, vaccination history, and immune response characteristics, that contribute to the waning of antibodies after repeated influenza vaccinations. These findings underscore the importan…
View article: Intranasal administration of split-inactivated influenza virus vaccine mixed with a novel adjuvant elicits protective antibodies against seasonal influenza viruses
Intranasal administration of split-inactivated influenza virus vaccine mixed with a novel adjuvant elicits protective antibodies against seasonal influenza viruses Open
Seasonal influenza remains a persistent global health concern, and despite the availability of vaccines, there are both limitations in vaccine effectiveness and needle-associated hesitancy that reduce vaccine uptake. To address these chall…
View article: Elevated NK and T cell-associated cytokines in plasma are associated with serological response to influenza vaccination
Elevated NK and T cell-associated cytokines in plasma are associated with serological response to influenza vaccination Open
Introduction Numerous pre-vaccination factors are known to be associated with differential responses to influenza vaccination, including age, prior infection, vaccination history, immune cell frequencies, and transcriptomic profiles. Howev…
View article: Breadth of antibody activity elicited by an influenza B hemagglutinin vaccine is influenced by pre-existing immune responses to influenza B viruses
Breadth of antibody activity elicited by an influenza B hemagglutinin vaccine is influenced by pre-existing immune responses to influenza B viruses Open
Most people are exposed to influenza A and influenza B viruses (IBV) at an early age through natural infection or vaccination. These previous exposures can shape future immune responses and the ability to either recall memory B cells or ge…
View article: Self-amplifying mRNA expressing COBRA hemagglutinin elicits long-lasting, broadly reactive antibodies against seasonal influenza A viruses
Self-amplifying mRNA expressing COBRA hemagglutinin elicits long-lasting, broadly reactive antibodies against seasonal influenza A viruses Open
View article: Obese individuals exhibit distinct temporal gene expression dynamics in response to influenza vaccination
Obese individuals exhibit distinct temporal gene expression dynamics in response to influenza vaccination Open
The effectiveness of the seasonal influenza vaccine varies between individuals. Specific risk groups with comorbidities, such as the obese, have an increased risk of infection even when vaccinated. It has been proposed that a heightened ba…
View article: Leveraging pre-vaccination antibody titres across multiple influenza H3N2 variants to forecast the post-vaccination response
Leveraging pre-vaccination antibody titres across multiple influenza H3N2 variants to forecast the post-vaccination response Open
NIAID, UCSD PREPARE Institute, LJI & Kyowa Kirin, Inc. (KKNA-Kyowa Kirin North America), UGA, Cleveland Clinic, the Georgia Research Alliance, and the Bodman family.
View article: Induction of Antigen-Specific Tolerance in a Multiple Sclerosis Model without Broad Immunosuppression
Induction of Antigen-Specific Tolerance in a Multiple Sclerosis Model without Broad Immunosuppression Open
Development of tolerogenic microparticle (MP) therapy made of acetalated dextran and loaded with antigenic peptide and tolerizing drug rapamycin (Rapa) to address problems with Multiple Sclerosis (MS) autoimmune disease.
View article: Assessing Factors Associated with One-Year Antibody Waning in Participants with Repeated Influenza Vaccinations: A Six-Year Cohort Study
Assessing Factors Associated with One-Year Antibody Waning in Participants with Repeated Influenza Vaccinations: A Six-Year Cohort Study Open
View article: Leveraging Pre-Vaccination Antibody Titers across Multiple Influenza H3N2 Variants to Forecast the Post-Vaccination Response
Leveraging Pre-Vaccination Antibody Titers across Multiple Influenza H3N2 Variants to Forecast the Post-Vaccination Response Open
Despite decades of research on the influenza virus, we still lack a predictive understanding of how vaccination reshapes each person's antibody response, which impedes efforts to design better vaccines. Here, we combined fifteen prior H3N2…
View article: Longitudinal assessment of human antibody binding to hemagglutinin elicited by split-inactivated influenza vaccination over six consecutive seasons
Longitudinal assessment of human antibody binding to hemagglutinin elicited by split-inactivated influenza vaccination over six consecutive seasons Open
Participants between the ages of 10–86 years old were vaccinated with split-inactivated influenza vaccine (Fluzone®) in six consecutive influenza seasons from 2016–2017 to 2021–2022. Vaccine effectiveness varies from season to season as a …
View article: Polymeric cGAMP microparticles affect the immunogenicity of a broadly active influenza mRNA lipid nanoparticle vaccine
Polymeric cGAMP microparticles affect the immunogenicity of a broadly active influenza mRNA lipid nanoparticle vaccine Open
View article: Retraction for Carter et al., “Elicitation of Protective Antibodies against a Broad Panel of H1N1 Viruses in Ferrets Preimmune to Historical H1N1 Influenza Viruses”
Retraction for Carter et al., “Elicitation of Protective Antibodies against a Broad Panel of H1N1 Viruses in Ferrets Preimmune to Historical H1N1 Influenza Viruses” Open
Volume 91, no. 24, e01283-17, 2017, https://doi.org/10.1128/jvi.01283-17. The authors are retracting this article due to incomplete reporting of "Naive" group data in Fig. 8A and B and absence of original underlying data.
View article: Complex changes in serum protein levels in COVID-19 convalescents
Complex changes in serum protein levels in COVID-19 convalescents Open
The COVID-19 pandemic, triggered by severe acute respiratory syndrome coronavirus 2, has affected millions of people worldwide. Much research has been dedicated to our understanding of COVID-19 disease heterogeneity and severity, but less …
View article: Immunogenicity of an adjuvanted broadly active influenza vaccine in immunocompromised and diverse populations
Immunogenicity of an adjuvanted broadly active influenza vaccine in immunocompromised and diverse populations Open
Influenza virus outbreaks are a major burden worldwide each year. Current vaccination strategies are inadequate due to antigenic drift/shift of the virus and the elicitation of low immune responses. The use of computationally optimized bro…
View article: Distinct Functional Humoral Immune Responses Are Induced after Live Attenuated and Inactivated Seasonal Influenza Vaccination
Distinct Functional Humoral Immune Responses Are Induced after Live Attenuated and Inactivated Seasonal Influenza Vaccination Open
Influenza viruses infect 5–30% of the world’s population annually, resulting in millions of incidents of hospitalization and thousands of mortalities worldwide every year. Although annual vaccination has significantly reduced hospitalizati…
View article: A computationally optimized broadly reactive hemagglutinin vaccine elicits neutralizing antibodies against influenza B viruses from both lineages
A computationally optimized broadly reactive hemagglutinin vaccine elicits neutralizing antibodies against influenza B viruses from both lineages Open
View article: Differential cross-reactivity to the influenza B virus haemagglutinin underpins lineage-specific susceptibility between birth cohorts
Differential cross-reactivity to the influenza B virus haemagglutinin underpins lineage-specific susceptibility between birth cohorts Open
Influenza exposures early in life are believed to shape future susceptibility to influenza infections by imprinting immunological biases that engender differential cross-reactivity to future influenza viruses, but direct serological eviden…
View article: Assessment of Humoral Immune Responses to Repeated Influenza Vaccination in a Multiyear Cohort: A 5-Year Follow-up
Assessment of Humoral Immune Responses to Repeated Influenza Vaccination in a Multiyear Cohort: A 5-Year Follow-up Open
The long-term effects of host factors on vaccine-elicited immune responses have not been well studied, and the interactions of host factors with annual influenza vaccinations are yet to be explored. We analyzed data from a cohort of 386 in…
View article: Zinc Carnosine Metal–Organic Coordination Polymer as a Potent Broadly Active Influenza Vaccine Platform with In Vitro Shelf-Stability
Zinc Carnosine Metal–Organic Coordination Polymer as a Potent Broadly Active Influenza Vaccine Platform with In Vitro Shelf-Stability Open
ZnCar was used to deliver COBRA Y2 and the adjuvant CpG. When used as delivery vehicle for subunit vaccine, it shows potential due to its superior immunogenicity and in vitro storage stability.
View article: Structural insights into the broad protection against H1 influenza viruses by a computationally optimized hemagglutinin vaccine
Structural insights into the broad protection against H1 influenza viruses by a computationally optimized hemagglutinin vaccine Open
View article: Development of a broadly active influenza intranasal vaccine adjuvanted with self-assembled particles composed of mastoparan-7 and CpG
Development of a broadly active influenza intranasal vaccine adjuvanted with self-assembled particles composed of mastoparan-7 and CpG Open
Currently licensed vaccine adjuvants offer limited mucosal immunity, which is needed to better combat respiratory infections such as influenza. Mast cells (MCs) are emerging as a target for a new class of mucosal vaccine adjuvants. Here, w…
View article: Development of a broadly active influenza intranasal vaccine adjuvanted with self-assembled particles composed of mastoparan-7 and CpG
Development of a broadly active influenza intranasal vaccine adjuvanted with self-assembled particles composed of mastoparan-7 and CpG Open
Currently licensed vaccine adjuvants offer limited mucosal immunity, which is needed to better combat respiratory infections such as influenza. Mast cells (MCs) are emerging as a target for a new class of mucosal vaccine adjuvants. Here, w…
View article: Vinyl Sulfone-functionalized Acetalated Dextran Microparticles as a Subunit Broadly Acting Influenza Vaccine
Vinyl Sulfone-functionalized Acetalated Dextran Microparticles as a Subunit Broadly Acting Influenza Vaccine Open
View article: Urine Metabolome Dynamics Discriminate Influenza Vaccination Response
Urine Metabolome Dynamics Discriminate Influenza Vaccination Response Open
Influenza represents a major and ongoing public health hazard. Current collaborative efforts are aimed toward creating a universal flu vaccine with the goals of both improving responses to vaccination and increasing the breadth of protecti…
View article: Sustained delivery of CpG oligodeoxynucleotide by acetalated dextran microparticles augments effector response to Computationally Optimized Broadly Reactive Antigen (COBRA) influenza hemagglutinin
Sustained delivery of CpG oligodeoxynucleotide by acetalated dextran microparticles augments effector response to Computationally Optimized Broadly Reactive Antigen (COBRA) influenza hemagglutinin Open
View article: Proteomic Signatures of the Serological Response to Influenza Vaccination in a Large Human Cohort Study
Proteomic Signatures of the Serological Response to Influenza Vaccination in a Large Human Cohort Study Open
The serological response to the influenza virus vaccine is highly heterogeneous for reasons that are not entirely clear. While the impact of demographic factors such as age, body mass index (BMI), sex, prior vaccination and titer levels ar…
View article: Vaccination History, Body Mass Index, Age, and Baseline Gene Expression Predict Influenza Vaccination Outcomes
Vaccination History, Body Mass Index, Age, and Baseline Gene Expression Predict Influenza Vaccination Outcomes Open
Seasonal influenza is a primary public health burden in the USA and globally. Annual vaccination programs are designed on the basis of circulating influenza viral strains. However, the effectiveness of the seasonal influenza vaccine is hig…
View article: Complex changes in serum protein levels in COVID-19 convalescents
Complex changes in serum protein levels in COVID-19 convalescents Open
The COVID-19 pandemic, triggered by severe acute respiratory syndrome coronavirus 2, has affected millions of people worldwide. Much research has been dedicated to our understanding of COVID-19 disease heterogeneity and severity, but less …
View article: α2,6-Sialylation Is Upregulated in Severe COVID-19, Implicating the Complement Cascade
α2,6-Sialylation Is Upregulated in Severe COVID-19, Implicating the Complement Cascade Open
Better understanding of the molecular mechanisms underlying COVID-19 severity is desperately needed in current times. Although hyper-inflammation drives severe COVID-19, precise mechanisms triggering this cascade and what role glycosylatio…