Michael A. Chesney
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View article: Distinctive regulatory architectures of germline-active and somatic genes in <i>C. elegans</i>
Distinctive regulatory architectures of germline-active and somatic genes in <i>C. elegans</i> Open
RNA profiling has provided increasingly detailed knowledge of gene expression patterns, yet the different regulatory architectures that drive them are not well understood. To address this, we profiled and compared transcriptional and regul…
View article: Tissue-specific profiling reveals distinctive regulatory architectures for ubiquitous, germline and somatic genes
Tissue-specific profiling reveals distinctive regulatory architectures for ubiquitous, germline and somatic genes Open
Despite increasingly detailed knowledge of gene expression patterns, the regulatory architectures that drive them are not well understood. To address this, we compared transcriptional and regulatory element activities across five adult tis…
View article: Stable Caenorhabditis elegans chromatin domains separate broadly expressed and developmentally regulated genes.
Stable Caenorhabditis elegans chromatin domains separate broadly expressed and developmentally regulated genes. Open
Eukaryotic genomes are organized into domains of differing structure and activity. There is evidence that the domain organization of the genome regulates its activity, yet our understanding of domain properties and the factors that influen…
View article: Stable<i>C. elegans</i>chromatin domains separate broadly expressed and developmentally regulated genes
Stable<i>C. elegans</i>chromatin domains separate broadly expressed and developmentally regulated genes Open
Eukaryotic genomes are organized into domains of differing structure and activity. There is evidence that the domain organization of the genome regulates its activity, yet our understanding of domain properties and the factors that influen…