Michael A. DiCandia
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View article: A conserved switch controls virulence, sporulation, and motility in C. difficile
A conserved switch controls virulence, sporulation, and motility in C. difficile Open
Spore formation is required for environmental survival and transmission of the human enteropathogenic Clostridioides difficile . In all bacterial spore formers, sporulation is regulated through activation of the master response regulator, …
View article: Glycine fermentation by <i>C. difficile</i> promotes virulence and spore formation, and is induced by host cathelicidin
Glycine fermentation by <i>C. difficile</i> promotes virulence and spore formation, and is induced by host cathelicidin Open
Clostridioides difficile is a leading cause of antibiotic-associated diarrheal disease. C. difficile colonization, growth, and toxin production in the intestine is strongly associated with its ability to use amino acids to generate energy,…
View article: Glycine fermentation by<i>C. difficile</i>promotes virulence, spore formation, and is induced by host cathelicidin
Glycine fermentation by<i>C. difficile</i>promotes virulence, spore formation, and is induced by host cathelicidin Open
SUMMARY The amino acid glycine is enriched in the dysbiotic gut and is suspected to contribute to Clostridioides difficile infection. We hypothesized that the use of glycine as an energy source contributes to colonization of the intestine …
View article: A Conserved Switch Controls Virulence, Sporulation, and Motility in<i>C. difficile</i>
A Conserved Switch Controls Virulence, Sporulation, and Motility in<i>C. difficile</i> Open
SUMMARY Spore formation is required for environmental survival and transmission of the human enteropathogenic Clostridioides difficile . In all bacterial spore formers, sporulation is regulated through activation of the master response reg…
View article: Three Orphan Histidine Kinases Inhibit Clostridioides difficile Sporulation
Three Orphan Histidine Kinases Inhibit Clostridioides difficile Sporulation Open
The formation of inactive spores is critical for the long-term survival of the gastrointestinal pathogen Clostridioides difficile . The onset of sporulation is controlled by the master regulator of sporulation, Spo0A, which is activated by…
View article: Identification of functional Spo0A residues critical for sporulation in <i>Clostridioides difficile</i>
Identification of functional Spo0A residues critical for sporulation in <i>Clostridioides difficile</i> Open
Clostridioides difficile is an anaerobic, Gram-positive pathogen that is responsible for C. difficile infection (CDI). To survive in the environment and spread to new hosts, C. difficile must form metabolically-dormant spores. The formatio…
View article: Three orphan histidine kinases inhibit <i>Clostridioides difficile</i> sporulation
Three orphan histidine kinases inhibit <i>Clostridioides difficile</i> sporulation Open
The ability of the anaerobic gastrointestinal pathogen, Clostridioides difficile , to survive outside the host relies on the formation of dormant endospores. Spore formation is contingent on the activation of a conserved transcription fact…