Michael A. Elliott
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View article: Effects of CT-388, a once-weekly signaling-biased dual GLP-1/GIP receptor agonist, on weight loss and glycemic control in preclinical models and participants with obesity
Effects of CT-388, a once-weekly signaling-biased dual GLP-1/GIP receptor agonist, on weight loss and glycemic control in preclinical models and participants with obesity Open
Biased agonism of the glucagon-like peptide-1/glucose-dependent insulinotropic polypeptide receptors (GLP-1R/GIPR) yields greater weight loss and better glycemic control than unbiased agonism in preclinical models. To evaluate whether bias…
View article: Beyond the "fandom as religion" comparison: Measuring the sacred dimensions of Comic-Con fan devotion
Beyond the "fandom as religion" comparison: Measuring the sacred dimensions of Comic-Con fan devotion Open
Why do people become devoted fans of popular culture, such that it becomes a central and meaningful part of their lives? This is a fundamental question of fan studies research. We approach it from a sociological perspective, building on th…
View article: Acknowledgments
Acknowledgments Open
Acknowl edgmentsAcknowl edgments are an event and not a structure.And the fact that this book took me so long to write intensifies all the ordinary prob lems of the genre: how it depends on memory, and how difficult it is to describe the d…
View article: Effect of sodium phenylbutyrate/taurursodiol on tracheostomy/ventilation-free survival and hospitalisation in amyotrophic lateral sclerosis: long-term results from the CENTAUR trial
Effect of sodium phenylbutyrate/taurursodiol on tracheostomy/ventilation-free survival and hospitalisation in amyotrophic lateral sclerosis: long-term results from the CENTAUR trial Open
Background Coformulated sodium phenylbutyrate/taurursodiol (PB/TURSO) was shown to prolong survival and slow functional decline in amyotrophic lateral sclerosis (ALS). Objective Determine whether PB/TURSO prolonged tracheostomy/ventilation…
View article: Amyotrophic Lateral Sclerosis and Multiple Sclerosis: More Evidence Suggesting a Link
Amyotrophic Lateral Sclerosis and Multiple Sclerosis: More Evidence Suggesting a Link Open
Objectives Previous reports of the concurrence of multiple sclerosis (MS) and amyotrophic lateral sclerosis (ALS) in the same patients suggest shared pathogenesis, with the C9orf72 mutation as a possible shared genetic link.
Methods: Symp…
View article: Fandom as religion: A social-scientific assessment
Fandom as religion: A social-scientific assessment Open
My objective in this article is to outline both a conceptual and a methodological reframing of the ‘fandom as religion’ comparison from a social-scientific perspective. This comparison is familiar territory by now. It has survived the deca…
View article: Long‐term survival of participants in the <scp>CENTAUR</scp> trial of sodium phenylbutyrate‐taurursodiol in <scp>amyotrophic lateral sclerosis</scp>
Long‐term survival of participants in the <span>CENTAUR</span> trial of sodium phenylbutyrate‐taurursodiol in <span>amyotrophic lateral sclerosis</span> Open
An orally administered, fixed‐dose coformulation of sodium phenylbutyrate‐taurursodiol (PB‐TURSO) significantly slowed functional decline in a randomized, placebo‐controlled, phase 2 trial in ALS (CENTAUR). Herein we report results of a lo…
View article: Trial of Sodium Phenylbutyrate–Taurursodiol for Amyotrophic Lateral Sclerosis
Trial of Sodium Phenylbutyrate–Taurursodiol for Amyotrophic Lateral Sclerosis Open
Sodium phenylbutyrate-taurursodiol resulted in slower functional decline than placebo as measured by the ALSFRS-R score over a period of 24 weeks. Secondary outcomes were not significantly different between the two groups. Longer and large…
View article: Eye‐controlled, power wheelchair performs well for ALS patients
Eye‐controlled, power wheelchair performs well for ALS patients Open
Background Our pilot study tested the feasibility and performance of an eye‐controlled power wheelchair for amyotrophic lateral sclerosis (ALS) patients. Methods In this prospective pilot study, participants drove the wheelchair three time…
View article: Contact Sports as a Risk Factor for Amyotrophic Lateral Sclerosis: A Systematic Review
Contact Sports as a Risk Factor for Amyotrophic Lateral Sclerosis: A Systematic Review Open
Study Design: Systematic review. Introduction: Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease, ultimately resulting in paralysis and death. The condition is considered to be caused by a complex interaction b…
View article: The State of Open Monographs
The State of Open Monographs Open
This report addresses the question of how we integrate and value monographs in the increasingly open digital scholarly network.Analysis from industry experts looks at the open monograph landscape in 2019, the impact and role of monographs …
View article: World heritage and the scientific consecration of ‘outstanding universal value’
World heritage and the scientific consecration of ‘outstanding universal value’ Open
Since World War II, the world heritage movement generated widespread support for preserving various sites of natural and cultural significance deemed to have outstanding universal value (OUV) for humanity. While the designation and evaluat…
View article: Death with dignity in Washington patients with amyotrophic lateral sclerosis
Death with dignity in Washington patients with amyotrophic lateral sclerosis Open
Although a small number, ALS represents the disease with the highest proportion of patients seeking to participate in DWD. Patients with ALS who choose DWD are well-educated and have access to palliative or life-prolonging care. The use of…
View article: Diffusion and decoupling in the world heritage movement: exploring global/local tensions in Africa
Diffusion and decoupling in the world heritage movement: exploring global/local tensions in Africa Open
A common critique of world society theory is that it overemphasises processes of institutional expansion and isomorphism, and underemphasises instances of decoupling and local variation. We address this concern head-on through an analysis …
View article: Tourism and Sustainability in the Evaluation of World Heritage Sites, 1980–2010
Tourism and Sustainability in the Evaluation of World Heritage Sites, 1980–2010 Open
At present, there are myriad concerns about tourism and sustainability at cultural and natural world heritage sites. Based on an analysis of 811 evaluations written between 1980 and 2010 by two official advisory bodies to the World Heritag…