Michael A. Kowalski
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View article: Improved Cartilage Protection with Low Molecular Weight Hyaluronic Acid Hydrogel
Improved Cartilage Protection with Low Molecular Weight Hyaluronic Acid Hydrogel Open
Traumatic joint injuries are common, leading to progressive tissue degeneration and the development of osteoarthritis. The post-traumatic joint experiences a pro-inflammatory milieu, initiating a subtle but deteriorative process in cartila…
View article: Exogenous All-<i>Trans</i>Retinoic Acid Induces Myopia and Alters Scleral Biomechanics in Mice
Exogenous All-<i>Trans</i>Retinoic Acid Induces Myopia and Alters Scleral Biomechanics in Mice Open
In mice, atRA treatment results in an axial myopia phenotype. Eyes developed myopic RE and larger VCD without the anterior eye being affected. The decrease in stiffness and increase in permeability of the sclera are consistent with the for…
View article: Altered Structure and Function of Murine Sclera in Form-Deprivation Myopia
Altered Structure and Function of Murine Sclera in Form-Deprivation Myopia Open
We report that biomechanics and GAG content of the mouse sclera are altered during myopigenesis. All scleral outcomes generally follow the trends found in other species and support a retina-to-sclera signaling cascade underlying mouse myop…
View article: Cartilage-penetrating hyaluronic acid hydrogel preserves tissue content and reduces chondrocyte catabolism
Cartilage-penetrating hyaluronic acid hydrogel preserves tissue content and reduces chondrocyte catabolism Open
Articular cartilage injuries have a limited healing capacity and, due to inflammatory and catabolic activities, often experience progressive degeneration towards osteoarthritis. Current repair techniques generally provide short-term sympto…
View article: Meniscal repair: The current state and recent advances in augmentation
Meniscal repair: The current state and recent advances in augmentation Open
Meniscal injuries represent one of the most common orthopedic injuries. The most frequent treatment is partial resection of the meniscus, or meniscectomy, which can affect joint mechanics and health. For this reason, the field has shifted …