Michael A. Mastrangelo
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View article: Genome-Wide Association Transethnic Meta-Analyses Identifies Novel Associations Regulating Coagulation Factor VIII and von Willebrand Factor Plasma Levels
Genome-Wide Association Transethnic Meta-Analyses Identifies Novel Associations Regulating Coagulation Factor VIII and von Willebrand Factor Plasma Levels Open
Background: Factor VIII (FVIII) and its carrier protein von Willebrand factor (VWF) are associated with risk of arterial and venous thrombosis and with hemorrhagic disorders. We aimed to identify and functionally test novel genetic associa…
View article: Acetylcholine inhibits platelet activation and regulates hemostasis
Acetylcholine inhibits platelet activation and regulates hemostasis Open
Platelets are key mediators of thrombosis. Many agonists of platelet activation are known, but there are fewer identified endogenous inhibitors of platelets, such as prostacyclin and nitric oxide (NO). Acetylcholinesterase inhibitors such …
View article: Interleukin-17 limits hypoxia-inducible factor 1α and development of hypoxic granulomas during tuberculosis
Interleukin-17 limits hypoxia-inducible factor 1α and development of hypoxic granulomas during tuberculosis Open
Mycobacterium tuberculosis (Mtb) is a global health threat, compounded by the emergence of drug-resistant strains. A hallmark of pulmonary tuberculosis (TB) is the formation of hypoxic necrotic granulomas, which upon disintegration, releas…
View article: Novel Thrombotic Function of a Human SNP in <i>STXBP5</i> Revealed by CRISPR/Cas9 Gene Editing in Mice
Novel Thrombotic Function of a Human SNP in <i>STXBP5</i> Revealed by CRISPR/Cas9 Gene Editing in Mice Open
Objective— To identify and characterize the effect of a SNP (single-nucleotide polymorphism) in the STXBP5 locus that is associated with altered thrombosis in humans. GWAS (genome-wide association studies) have identified numerous SNPs ass…
View article: SIRT6 protects against endothelial dysfunction and atherosclerosis in mice
SIRT6 protects against endothelial dysfunction and atherosclerosis in mice Open
SIRT6 is an important member of sirtuin family that represses inflammation, aging and DNA damage, three of which are causing factors for endothelial dysfunction. SIRT6 expression is decreased in atherosclerotic lesions from ApoE(-/-) mice …
View article: A novel TRPV4-specific agonist inhibits monocyte adhesion and atherosclerosis
A novel TRPV4-specific agonist inhibits monocyte adhesion and atherosclerosis Open
TRPV4 ion channel mediates vascular mechanosensitivity and vasodilation. Here, we sought to explore whether non-mechanical activation of TRPV4 could limit vascular inflammation and atherosclerosis. We found that GSK1016790A, a potent and s…