Achim Aigner
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View article: Xenograft tissue slice tandem co-cultures are a highly specific model to selectively analyze drug inhibitory effects on glioblastoma invasion
Xenograft tissue slice tandem co-cultures are a highly specific model to selectively analyze drug inhibitory effects on glioblastoma invasion Open
Test systems enabling preclinical assessment of drug effects in relevant models are essential for optimizing the selection of candidate therapeutics before their further clinical translation. Xenograft tissue slice tandem co-culture (XTCC)…
View article: ERBB3 influences the ferroptosis pathway via modulation of lipid peroxidation and GSH synthesis in gastric cancer
ERBB3 influences the ferroptosis pathway via modulation of lipid peroxidation and GSH synthesis in gastric cancer Open
View article: RNA drugs and nonviral nanocarriers in oncology – present status and emerging concepts
RNA drugs and nonviral nanocarriers in oncology – present status and emerging concepts Open
RNA molecules offer attractive therapeutic strategies in oncology, based on mechanisms of action different to existing medications. The therapeutic application of RNAs, however, is still associated with major bottlenecks, including poor st…
View article: Nose-to-brain siRNA delivery by PEI/PPI-based nanoparticles reduces α-synuclein expression in a Parkinson’s disease mouse model
Nose-to-brain siRNA delivery by PEI/PPI-based nanoparticles reduces α-synuclein expression in a Parkinson’s disease mouse model Open
Potential strategies to develop new treatments for Parkinson's disease (PD) aim at targeting disease-associated proteins like alpha-synuclein (aSyn), which accumulates in neurons of PD patients and contributes to neuronal degeneration. A p…
View article: POS1190 MORTALITY RATES AND CAUSES OF DEATH AMONG PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS – THE FORWARD LUPUS REGISTRY
POS1190 MORTALITY RATES AND CAUSES OF DEATH AMONG PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS – THE FORWARD LUPUS REGISTRY Open
View article: The MicroRNA miR-454 and the mediator complex component MED12 are regulators of the androgen receptor pathway in prostate cancer
The MicroRNA miR-454 and the mediator complex component MED12 are regulators of the androgen receptor pathway in prostate cancer Open
Prostate cancer that is resistant to anti-androgen treatment, such as enzalutamide, represents a therapeutic challenge. To study their molecular and functional features, the enzalutamide-resistant PCa cell lines LNCaP Abl EnzR and DuCaP En…
View article: Analysis of Polymer/siRNA Nanoparticle Efficacy and Biocompatibility in 3D Air–Liquid Interface Culture Compared to 2D Cell Culture
Analysis of Polymer/siRNA Nanoparticle Efficacy and Biocompatibility in 3D Air–Liquid Interface Culture Compared to 2D Cell Culture Open
Background: Polymeric nanoparticles have been explored as efficient tools for siRNA delivery to induce RNAi-mediated gene knockdown. Chemical modifications of polyethylenimines (PEI) enhance nanoparticle efficacy and biocompatibility. Thei…
View article: Acquired vulnerability against EGF receptor inhibition in gastric cancer promoted by class I histone deacetylase inhibitor entinostat
Acquired vulnerability against EGF receptor inhibition in gastric cancer promoted by class I histone deacetylase inhibitor entinostat Open
Our findings establish the profound upregulation of the EGFR/AREG axis by entinostat as starting point for a rational combination therapy in gastric carcinoma.
View article: A new human autologous hepatocyte/macrophage co-culture system that mimics drug-induced liver injury–like inflammation
A new human autologous hepatocyte/macrophage co-culture system that mimics drug-induced liver injury–like inflammation Open
View article: The Histone Deacetylase Inhibitor Entinostat Mediates HER2 Downregulation in Gastric Cancer, Providing the Basis for Its Particular Efficacy in HER2-Amplified Tumors and in Combination Therapies
The Histone Deacetylase Inhibitor Entinostat Mediates HER2 Downregulation in Gastric Cancer, Providing the Basis for Its Particular Efficacy in HER2-Amplified Tumors and in Combination Therapies Open
Purpose Human epidermal growth factor receptor 2 (HER2) inhibition represents a therapeutic approach with proven clinical efficacy in gastric cancer. However, resistance against HER2-directed therapeutics highlights the need for alternativ…
View article: Recent advances in development and delivery of non-viral nucleic acid therapeutics for brain tumor therapy
Recent advances in development and delivery of non-viral nucleic acid therapeutics for brain tumor therapy Open
High grade gliomas (HGG) are a group of CNS tumors refractory to currently existing therapies, which routinely leads to early recurrence and a dismal prognosis. Recent advancements in nucleic acid-based therapy using a wide variety of diff…
View article: MED12 and CDK8/19 Modulate Androgen Receptor Activity and Enzalutamide Response in Prostate Cancer
MED12 and CDK8/19 Modulate Androgen Receptor Activity and Enzalutamide Response in Prostate Cancer Open
Prostate cancer progression is driven by androgen receptor (AR) activity, which is a target for therapeutic approaches. Enzalutamide is an AR inhibitor that prolongs the survival of patients with advanced prostate cancer. However, resistan…
View article: Vorinostat Treatment of Gastric Cancer Cells Leads to ROS-Induced Cell Inhibition and a Complex Pattern of Molecular Alterations in Nrf2-Dependent Genes
Vorinostat Treatment of Gastric Cancer Cells Leads to ROS-Induced Cell Inhibition and a Complex Pattern of Molecular Alterations in Nrf2-Dependent Genes Open
Histone deacetylase inhibitors (HDACi) show high antineoplastic potential in preclinical studies in various solid tumors, including gastric carcinoma; however, their use in clinical studies has not yet yielded convincing efficacies. Thus, …
View article: The Concentration of Salivary Extracellular Vesicles Is Related to Obesity
The Concentration of Salivary Extracellular Vesicles Is Related to Obesity Open
Background and aims: Saliva is essential for the proper dilution and distribution of taste molecules on the tongue. It harbors extracellular vesicles (EVs), which mediate cell–cell communication. Changes in the composition of salivary EVs …
View article: Mesoporous Silica-Based Membranes in Transdermal Drug Delivery: The Role of Drug Loss in the Skin
Mesoporous Silica-Based Membranes in Transdermal Drug Delivery: The Role of Drug Loss in the Skin Open
Compared to other forms of drug administration, the use of Transdermal Drug Delivery Systems (TDDSs) offers significant advantages, including uniform drug release profiles that contribute to lower side effects and higher tolerability, avoi…
View article: HDAC inhibitors activate lipid peroxidation and ferroptosis in gastric cancer
HDAC inhibitors activate lipid peroxidation and ferroptosis in gastric cancer Open
Gastric cancer remains among the deadliest neoplasms worldwide, with limited therapeutic options. Since efficacies of targeted therapies are unsatisfactory, drugs with broader mechanisms of action rather than a single oncogene inhibition a…
View article: Spray-drying of PEI-/PPI-based nanoparticles for DNA or siRNA delivery
Spray-drying of PEI-/PPI-based nanoparticles for DNA or siRNA delivery Open
Spray-drying of nucleic acid-based drugs designed for gene therapy or gene knockdown is associated with many advantages including storage stability and handling as well as the possibility of pulmonary application. The encapsulation of nucl…
View article: Efficient polymeric nanoparticles for RNAi in macrophage reveal complex effects on polarization markers upon knockdown of STAT3/STAT6
Efficient polymeric nanoparticles for RNAi in macrophage reveal complex effects on polarization markers upon knockdown of STAT3/STAT6 Open
Tumor associated macrophages (TAMs) are the most abundant immune cell type in the tissue microenvironment, affecting tumor progression, metastasis and therapeutic response. Different macrophage activation ("polarization") states can be dis…
View article: Chemical surface modification of mesoporous SiO2-based membranes for fine-tuning of drug loading and release properties
Chemical surface modification of mesoporous SiO2-based membranes for fine-tuning of drug loading and release properties Open
Transdermal Drug Delivery Systems (TDDS) show significant advantages over other forms of drug application. Despite their clinical use for decades, these drug delivery devices have yet to reach their full potential. While polymer matrices a…
View article: MED12 promotes Prostate Cancer (PCa) cell proliferation through the Androgen Receptor (AR) signalling
MED12 promotes Prostate Cancer (PCa) cell proliferation through the Androgen Receptor (AR) signalling Open
View article: MicroRNA-30d-5p—A Potential New Therapeutic Target for Prevention of Ischemic Cardiomyopathy after Myocardial Infarction
MicroRNA-30d-5p—A Potential New Therapeutic Target for Prevention of Ischemic Cardiomyopathy after Myocardial Infarction Open
(1) Background and Objective: MicroRNAs (miRs) are biomarkers for assessing the extent of cardiac remodeling after myocardial infarction (MI) and important predictors of clinical outcome in heart failure. Overexpression of miR-30d-5p appea…
View article: In Reply
In Reply Open
View article: MicroRNA-30d—A Potential New Therapeutic Target for Prevention of Ischemic Cardiomyopathy after Myocardial Infarction
MicroRNA-30d—A Potential New Therapeutic Target for Prevention of Ischemic Cardiomyopathy after Myocardial Infarction Open
(1) Background and Objective: MicroRNAs (miR) are biomarkers for assessing the extent of cardiac remodeling after myocardial infarction (MI) and important predictors of clinical outcome in heart failure. Overexpression of miR-30d appears t…
View article: The effect of novel tyrosine-modified polyethyleneimines on human albumin structure – Thermodynamic and spectroscopic study
The effect of novel tyrosine-modified polyethyleneimines on human albumin structure – Thermodynamic and spectroscopic study Open
The interaction of proteins with nanoparticle components are crucial for the evaluation of nanoparticle function, toxicity and biodistribution. Polyethyleneimines (PEIs) with defined tyrosine modifications are a class of novel polymers des…
View article: Antibody-drug conjugates as a targeted therapeutic approach across entities in oncology
Antibody-drug conjugates as a targeted therapeutic approach across entities in oncology Open
ADCs are a novel category of drugs for the treatment of cancer. Their approval is mainly, but not exclusively, based on the favorable findings of randomized, controlled phase III trials. ADCs are already helping to improve the outcomes of …
View article: Data from Critical Role of Gα<sub>12</sub> and Gα<sub>13</sub> for Human Small Cell Lung Cancer Cell Proliferation <i>In vitro</i> and Tumor Growth <i>In vivo</i>
Data from Critical Role of Gα<sub>12</sub> and Gα<sub>13</sub> for Human Small Cell Lung Cancer Cell Proliferation <i>In vitro</i> and Tumor Growth <i>In vivo</i> Open
Purpose: In small cell lung cancer cells (SCLC), various autocrine stimuli lead to the parallel activation of Gq/11 and G12/13 proteins. Although the contribution of the Gq/11-phospholipase C-β casca…
View article: Supplementary Data from Critical Role of Gα<sub>12</sub> and Gα<sub>13</sub> for Human Small Cell Lung Cancer Cell Proliferation <i>In vitro</i> and Tumor Growth <i>In vivo</i>
Supplementary Data from Critical Role of Gα<sub>12</sub> and Gα<sub>13</sub> for Human Small Cell Lung Cancer Cell Proliferation <i>In vitro</i> and Tumor Growth <i>In vivo</i> Open
Supplementary Data from Critical Role of Gα12 and Gα13 for Human Small Cell Lung Cancer Cell Proliferation In vitro and Tumor Growth In vivo
View article: Supplementary Data from Critical Role of Gα<sub>12</sub> and Gα<sub>13</sub> for Human Small Cell Lung Cancer Cell Proliferation <i>In vitro</i> and Tumor Growth <i>In vivo</i>
Supplementary Data from Critical Role of Gα<sub>12</sub> and Gα<sub>13</sub> for Human Small Cell Lung Cancer Cell Proliferation <i>In vitro</i> and Tumor Growth <i>In vivo</i> Open
Supplementary Data from Critical Role of Gα12 and Gα13 for Human Small Cell Lung Cancer Cell Proliferation In vitro and Tumor Growth In vivo
View article: Data from Critical Role of Gα<sub>12</sub> and Gα<sub>13</sub> for Human Small Cell Lung Cancer Cell Proliferation <i>In vitro</i> and Tumor Growth <i>In vivo</i>
Data from Critical Role of Gα<sub>12</sub> and Gα<sub>13</sub> for Human Small Cell Lung Cancer Cell Proliferation <i>In vitro</i> and Tumor Growth <i>In vivo</i> Open
Purpose: In small cell lung cancer cells (SCLC), various autocrine stimuli lead to the parallel activation of Gq/11 and G12/13 proteins. Although the contribution of the Gq/11-phospholipase C-β casca…
View article: Supplementary Methods and Materials from MicroRNA Replacement Therapy for miR-145 and miR-33a Is Efficacious in a Model of Colon Carcinoma
Supplementary Methods and Materials from MicroRNA Replacement Therapy for miR-145 and miR-33a Is Efficacious in a Model of Colon Carcinoma Open
Supplementary Methods and Materials from MicroRNA Replacement Therapy for miR-145 and miR-33a Is Efficacious in a Model of Colon Carcinoma