Anders Lindberg
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View article: Intraperitoneal infection of A/J and CD1 mice with coxsackievirus B2 and its mutants
Intraperitoneal infection of A/J and CD1 mice with coxsackievirus B2 and its mutants Open
Coxsackieviruses (CVs) belong to the genus Enterovirus and family Picornaviridae . Mutants can arise within the replication cycle of RNA viruses. The prototype CVB2 Ohio-1 (CVB2/O) strain adapted to rhabdomyosarcoma (RD) cells induced cyto…
View article: Metagenomic analysis of Mesolithic chewed pitch reveals poor oral health among stone age individuals
Metagenomic analysis of Mesolithic chewed pitch reveals poor oral health among stone age individuals Open
Prehistoric chewed pitch has proven to be a useful source of ancient DNA, both from humans and their microbiomes. Here we present the metagenomic analysis of three pieces of chewed pitch from Huseby Klev, Sweden, that were dated to 9,890–9…
View article: Metagenomic analysis of Mesolithic chewed pitch reveals poor oral health among stone age individuals
Metagenomic analysis of Mesolithic chewed pitch reveals poor oral health among stone age individuals Open
Prehistoric chewed pitch has proven to be a useful source of ancient DNA, both from humans and their microbiomes. Here we present the metagenomic analysis of three pieces of chewed pitch from Huseby Klev, Sweden, that were dated to 9,890–9…
View article: Comparison of two prediction models in a clinical setting to predict growth in prepubertal children on recombinant growth hormone
Comparison of two prediction models in a clinical setting to predict growth in prepubertal children on recombinant growth hormone Open
We found that both the Gothenburg model and the KIGS model are equivalent when applying to our clinical cohort. Both models are very precise, hence it is encouraged to use either based on accessibility for the clinic.
View article: Individualized Growth Hormone Treatment - Using Two Different Prediction Models in a Clinical Setting
Individualized Growth Hormone Treatment - Using Two Different Prediction Models in a Clinical Setting Open
Background Diagnosing growth hormone deficiency (GHD) can be challenging; hence, prediction models on growth outcome from growth hormone (GH) treatment have shown to be useful. We aim to compare the accuracy of the more readily available K…
View article: A Genome-Wide Pharmacogenetic Study of Growth Hormone Responsiveness
A Genome-Wide Pharmacogenetic Study of Growth Hormone Responsiveness Open
Context Individual patients vary in their response to growth hormone (GH). No large-scale genome-wide studies have looked for genetic predictors of GH responsiveness. Objective To identify genetic variants associated with GH responsiveness…
View article: Early Entry Events in Echovirus 30 Infection
Early Entry Events in Echovirus 30 Infection Open
Echovirus 30 (E30) is a prevalent enterovirus causing regular outbreaks in both children and adults in different parts of the world. It is therefore surprising that relatively little is known of its infectious entry pathway. We set out to …
View article: Near-Adult Height After Growth Hormone Treatment in Children Born Prematurely—Data From KIGS
Near-Adult Height After Growth Hormone Treatment in Children Born Prematurely—Data From KIGS Open
Context Children born prematurely have been treated with growth hormone (GH), and a significant improvement in height during the first years of treatment has been described. Objective To evaluate the influence of prematurity on near-adult …
View article: Suppl Table 1.xlsx
Suppl Table 1.xlsx Open
Signals that were both polymorphic and had statistical significance in the replication sample.
View article: Slow Infection due to Lowering the Amount of Intact versus Empty Particles Is a Characteristic Feature of Coxsackievirus B5 Dictated by the Structural Proteins
Slow Infection due to Lowering the Amount of Intact versus Empty Particles Is a Characteristic Feature of Coxsackievirus B5 Dictated by the Structural Proteins Open
Enteroviruses cause several severe diseases, with lytic infections that lead to rapid cell death but also persistent infections that are more silent and lead to chronic states of infection. Our study compared a cytolytic echovirus 1 infect…
View article: Secular Trends on Birth Parameters, Growth, and Pubertal Timing in Girls with Turner Syndrome
Secular Trends on Birth Parameters, Growth, and Pubertal Timing in Girls with Turner Syndrome Open
BACKGROUND: Whether children with chromosomal disorders of growth and puberty are affected by secular trends (STs) as observed in the general population remains unanswered, but this question has relevance for expectations of spontaneous de…
View article: Racial/Ethnic Disparities in US Pediatric Growth Hormone Treatment
Racial/Ethnic Disparities in US Pediatric Growth Hormone Treatment Open
Background/Aims: To compare racial/ethnic proportions of subjects receiving growth hormone (GH) treatment to the expected proportions, and secondarily, to assess racial/ethnic differences in subject characteristics at GH treatment initiati…
View article: ICTV Virus Taxonomy Profile: Picornaviridae
ICTV Virus Taxonomy Profile: Picornaviridae Open
The family Picornaviridae comprises small non-enveloped viruses with RNA genomes of 6.7 to 10.1 kb, and contains >30 genera and >75 species. Most of the known picornaviruses infect mammals and birds, but some have also been detected in rep…
View article: Growth Hormone Treatment in Children With Prader-Willi Syndrome: Three Years of Longitudinal Data in Prepubertal Children and Adult Height Data From the KIGS Database
Growth Hormone Treatment in Children With Prader-Willi Syndrome: Three Years of Longitudinal Data in Prepubertal Children and Adult Height Data From the KIGS Database Open
GH treatment in children with PWS significantly improves linear growth. BMI remains on average below +2 SDS, in contrast to the natural course of increasing obesity in PWS. Safety should be closely monitored in children with PWS, with and …
View article: ICTV Virus Taxonomy Profile: Picornaviridae
ICTV Virus Taxonomy Profile: Picornaviridae Open
The family Picornaviridae comprises small non-enveloped viruses with RNA genomes of 6.7 to 10.1 kb, and contains >30 genera and >75 species. Most of the known picornaviruses infect mammals and birds, but some have also been detected …
View article: The Transcriptome of Rhabdomyosarcoma Cells Infected with Cytolytic and Non-Cytolytic Variants of Coxsackievirus B2 Ohio-1
The Transcriptome of Rhabdomyosarcoma Cells Infected with Cytolytic and Non-Cytolytic Variants of Coxsackievirus B2 Ohio-1 Open
The transcriptomes of cells infected with lytic and non-lytic variants of coxsackievirus B2 Ohio-1 (CVB2O) were analyzed using next generation sequencing. This approach was selected with the purpose of elucidating the effects of lytic and …
View article: Structure of Aichi Virus 1 and Its Empty Particle: Clues to Kobuvirus Genome Release Mechanism
Structure of Aichi Virus 1 and Its Empty Particle: Clues to Kobuvirus Genome Release Mechanism Open
Aichi virus 1 (AiV-1) is a human pathogen from the Kobuvirus genus of the Picornaviridae family. Worldwide, 80 to 95% of adults have antibodies against the virus. AiV-1 infections are associated with nausea, gastroenteritis, and fever. Unl…
View article: Structure and Genome Release Mechanism of the Human Cardiovirus Saffold Virus 3
Structure and Genome Release Mechanism of the Human Cardiovirus Saffold Virus 3 Open
In order to initiate an infection, viruses need to deliver their genomes into cells. This involves uncoating the genome and transporting it to the cytoplasm. The process of genome delivery is not well understood for nonenveloped viruses. W…
View article: Structure of Ljungan virus provides insight into genome packaging of this picornavirus
Structure of Ljungan virus provides insight into genome packaging of this picornavirus Open
Picornaviruses are responsible for a range of human and animal diseases, but how their RNA genome is packaged remains poorly understood. A particularly poorly studied group within this family are those that lack the internal coat protein, …
View article: Short Children with CHARGE Syndrome: Do They Benefit from Growth Hormone Therapy?
Short Children with CHARGE Syndrome: Do They Benefit from Growth Hormone Therapy? Open
Aim: The aim of this study was to evaluate the response to recombinant growth hormone (GH) treatment in short children with CHARGE syndrome. Patients: We identified 51 children (28 boys and 23 girls) in KIGS (Pfizer International Growth Da…