Michael Armbrust
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View article: Development of ACE2-tropic-betacoronavirus therapeutics for future pandemic preparedness
Development of ACE2-tropic-betacoronavirus therapeutics for future pandemic preparedness Open
A major challenge during viral pandemics is the ability to develop therapeutics whose efficacy can withstand viral genetic evolution. During the COVID-19 pandemic, five SARS-CoV-2 monoclonal antibody (mAb) therapeutics were rendered ineffe…
View article: P18.15.A IMMUNOCOMPETENT GLIOBLASTOMA ORGANOIDS FOR PERSONALIZED IMMUNE PROFILING
P18.15.A IMMUNOCOMPETENT GLIOBLASTOMA ORGANOIDS FOR PERSONALIZED IMMUNE PROFILING Open
BACKGROUND Glioblastoma (GB) is a highly aggressive brain tumor with poor prognosis and limited response to immunotherapies. Tumor intrinsic features like low mutational burden, and extrinsic factors such as T-cell dysfunction and an immun…
View article: Characteristics and Outcomes of Kidney Transplant Recipients with a Functioning Graft for More than 25 Years
Characteristics and Outcomes of Kidney Transplant Recipients with a Functioning Graft for More than 25 Years Open
Background: Information regarding the clinical characteristics and outcomes of kidney transplant recipients (KTRs) with > 25 years of graft survival is limited. Methods: In this single-center observational study, we characterized KTRs…