Michaël Atlan
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View article: Revealing neurovascular coupling at a high spatial and temporal resolution in the living human retina
Revealing neurovascular coupling at a high spatial and temporal resolution in the living human retina Open
Neurovascular coupling (NVC) regulates local blood flow in response to neuronal activity, yet its precise characterization at the capillary level has been hindered by the lack of a noninvasive, high-resolution imaging method. Here, we intr…
View article: Adaptive Optics Rolling Slit Ophthalmoscope: Combining cellular-resolution, high-speed and large field-of-view in a multimodal retinal imager
Adaptive Optics Rolling Slit Ophthalmoscope: Combining cellular-resolution, high-speed and large field-of-view in a multimodal retinal imager Open
Label-free optical imaging systems capable of monitoring dynamic biological processes over a large field-of-view (FOV) are essential for advancing our understanding of retinal and neurovascular health. However, existing imaging modalities …
View article: Measuring flicker induced vasodilation at a high spatial and temporal resolution in the human retina
Measuring flicker induced vasodilation at a high spatial and temporal resolution in the human retina Open
Neurovascular coupling (NVC) is a crucial process in which blood flow is dynamically adjusted to meet the metabolic demands of active neurons. In this study, we introduce an innovative method for in-vivo imaging of retinal blood vessel dil…
View article: Aberration compensation in Doppler holography of the human eye fundus by subaperture signal correlation
Aberration compensation in Doppler holography of the human eye fundus by subaperture signal correlation Open
The process of obtaining images of capillary vessels in the human eye’s fundus using Doppler holography encounters difficulties due to ocular aberrations. To enhance the accuracy of these images, it is advantageous to apply an adaptive abe…
View article: Doppler holography for ophthalmology
Doppler holography for ophthalmology Open
A comprehensive assessment of retinal health demands reliable and precise methods to measure localized blood perfusion. Despite considerable advancements in imaging techniques, such as indocyanine green and fluorescein angiography, along w…
View article: Multimodal high-resolution retinal imaging using a camera-based DMD-integrated adaptive optics flood-illumination ophthalmoscope
Multimodal high-resolution retinal imaging using a camera-based DMD-integrated adaptive optics flood-illumination ophthalmoscope Open
We demonstrate the feasibility of a multimodal adaptive optics flood-illumination ophthalmoscope, able to provide both bright-field and dark-field images (such as phase contrast). The multimodality was made possible by integrating a digita…
View article: Observation of natural flexural pulse waves in retinal and carotid arteries for wall elasticity estimation
Observation of natural flexural pulse waves in retinal and carotid arteries for wall elasticity estimation Open
The risk of cardiovascular events is linked to arterial elasticity that can be estimated from the pulse wave velocity. This symmetric wave velocity is related to the wall elasticity through the Moens-Korteweg equation. However, ultrasound …
View article: Multimodal high-resolution retinal imaging using camera-based DMD-integrated Adaptive Optics Flood-Illumination Ophthalmoscope
Multimodal high-resolution retinal imaging using camera-based DMD-integrated Adaptive Optics Flood-Illumination Ophthalmoscope Open
We demonstrate the feasibility of a multimodal adaptive optics flood-illumination ophthalmoscope, able to provide both bright-field and dark-field images (such as phase contrast). The multimodality was made possible by integrating a DMD at…
View article: Multimodal high-resolution retinal imaging using camera-based DMD-integrated Adaptive Optics Flood-Illumination Ophthalmoscope
Multimodal high-resolution retinal imaging using camera-based DMD-integrated Adaptive Optics Flood-Illumination Ophthalmoscope Open
We demonstrate the feasibility of a multimodal adaptive optics flood-illumination ophthalmoscope, able to provide both bright-field and dark-field images (such as phase contrast). The multimodality was made possible by integrating a DMD at…
View article: Diffuse laser illumination for Maxwellian view Doppler holography of the retina
Diffuse laser illumination for Maxwellian view Doppler holography of the retina Open
We present the benefits of using diffuse illumination in laser holography for ophthalmic applications. Integrating a diffusing element introduces angular diversity in the optical radiation and reduces spatial coherence, effectively distrib…
View article: Retinal micro-vascular network: data and model
Retinal micro-vascular network: data and model Open
International audience
View article: Retinal blood flow reversal quantitatively monitored in out-of-plane\n vessels with laser Doppler holography
Retinal blood flow reversal quantitatively monitored in out-of-plane\n vessels with laser Doppler holography Open
Laser Doppler holography is a planar blood flow imaging technique recently\nintroduced in ophthalmology to image human retinal and choroidal blood flow\nnon-invasively. Here we present a digital method based on the Doppler spectrum\nasymme…
View article: Retinal blood flow reversal in out-of-plane vessels imaged with laser Doppler holography
Retinal blood flow reversal in out-of-plane vessels imaged with laser Doppler holography Open
Laser Doppler holography is a planar blood flow imaging technique recently introduced in ophthalmology. We here present a digital method to reveal the local direction of blood flow with respect to the optical axis based on the Doppler spec…
View article: Reverse contrast laser Doppler holography for lower frame rate retinal and choroidal blood flow imaging
Reverse contrast laser Doppler holography for lower frame rate retinal and choroidal blood flow imaging Open
Laser Doppler holography (LDH) is an interferometric blood flow imaging technique based on full-field measurements of the Doppler spectrum. LDH has so far been demonstrated in the retina with ultrafast cameras, typically at 75 kHz. We show…
View article: Spatio-temporal filtering in laser Doppler holography for retinal blood flow imaging
Spatio-temporal filtering in laser Doppler holography for retinal blood flow imaging Open
Laser Doppler holography (LDH) is a full-field interferometric imaging technique recently applied in ophthalmology to measure blood flow, a parameter of high clinical interest. From the temporal fluctuations of digital holograms acquired a…
View article: Experimental digital Gabor hologram rendering by a model-trained convolutional neural network
Experimental digital Gabor hologram rendering by a model-trained convolutional neural network Open
Digital hologram rendering can be performed by a convolutional neural network, trained with image pairs calculated by numerical wave propagation from sparse generating images. 512-by-512 pixeldigital Gabor magnitude holograms are successfu…
View article: Real-time digital holography of the retina by principal component analysis
Real-time digital holography of the retina by principal component analysis Open
We demonstrate the feasibility of high-quality digital holography of the human retina in real-time with a fast camera and commodity computer hardware. High throughput rendering of digital Fresnel holograms from optically-acquired inline in…
View article: Low frame rate laser Doppler holography
Low frame rate laser Doppler holography Open
Laser Doppler holography (LDH) is an interferometric blood flow imaging technique based on full-field measurements of the Doppler broadening. So far, LDH has been demonstrated in the retina with ultrafast cameras, typically at 75 kHz. We s…
View article: Spatio-temporal filtering in laser Doppler holography
Spatio-temporal filtering in laser Doppler holography Open
Laser Doppler holography (LDH) is a full-field interferometric imaging technique recently applied in ophthalmology to measure blood flow, a parameter of high clinical interest. From the temporal fluctuations of digital holograms acquired a…
View article: Spatio-temporal filtering in laser Doppler holography for retinal blood\n flow imaging
Spatio-temporal filtering in laser Doppler holography for retinal blood\n flow imaging Open
Laser Doppler holography (LDH) is a full-field interferometric imaging\ntechnique recently applied in ophthalmology to measure blood flow, a parameter\nof high clinical interest. From the temporal fluctuations of digital holograms\nacquire…
View article: Swept-source optical coherence tomography by off-axis Fresnel transform digital holography with an output throughput of 10 Giga voxels per second in real-time
Swept-source optical coherence tomography by off-axis Fresnel transform digital holography with an output throughput of 10 Giga voxels per second in real-time Open
We demonstrate swept-source optical coherence tomography in real-time by high throughput digital Fresnel hologram rendering from optically-acquired interferograms with a high-speed camera. The interferogram stream is spatially rescaled wit…
View article: Spatio-temporal filtering in laser Doppler holography for retinal blood flow imaging
Spatio-temporal filtering in laser Doppler holography for retinal blood flow imaging Open
Laser Doppler holography (LDH) is a full-field interferometric imaging technique recently applied in ophthalmology to measure blood flow, a parameter of high clinical interest. From the temporal fluctuations of digital holograms acquired a…
View article: Frame rate reduction in laser Doppler holography
Frame rate reduction in laser Doppler holography Open
Laser Doppler holography (LDH) is an interferometric blood flow imaging technique based on full-field measurements of the Doppler broadening. So far, LDH has been demonstrated in the retina with ultrafast cameras, typically at 75 kHz. We s…
View article: Analysis of retinal and choroidal images measured by laser Doppler holography
Analysis of retinal and choroidal images measured by laser Doppler holography Open
Laser Doppler holography (LDH) is a full-field imaging technique that was recently used in the human eye to reveal blood flow contrasts in the retinal and choroidal vasculature non-invasively, and with high temporal resolution. We here dem…
View article: Motion Compensation In Digital Holography For Retinal Imaging
Motion Compensation In Digital Holography For Retinal Imaging Open
International audience