Michael A. Menze
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Multiomics Studies on Metabolism Changes in Alcohol-Associated Liver Disease Open
Metabolic dysfunction in the liver represents a predominant feature in the early stages of alcohol-associated liver disease (ALD). However, the mechanisms underlying this are only partially understood. To investigate the metabolic characte…
Biochemical control of the mitochondrial protein MitoNEET by biological thiols and lipid-derived electrophiles Open
MitoNEET is a mitochondrial [2Fe-2S] protein known for its involvement in cellular metabolism, iron regulation, and oxidative stress. The protein has been associated with diseases ranging from diabetes to Parkinson's disease which has prom…
The Mitochondrial Protein MitoNEET as a Probe for the Allostery of Glutamate Dehydrogenase Open
The proteins glutamate dehydrogenase (GDH) and mitoNEET are both targets of drug development efforts to treat metabolic disorders, cancer, and neurodegenerative diseases. However, these two proteins differ starkly in the current knowledge …
View article: LEAfing through literature: late embryogenesis abundant proteins coming of age—achievements and perspectives
LEAfing through literature: late embryogenesis abundant proteins coming of age—achievements and perspectives Open
To deal with increasingly severe periods of dehydration related to global climate change, it becomes increasingly important to understand the complex strategies many organisms have developed to cope with dehydration and desiccation. While …
Functional and Conformational Plasticity of an Animal Group 1 LEA Protein Open
Group 1 (Dur-19, PF00477, LEA_5) Late Embryogenesis Abundant (LEA) proteins are present in organisms from all three domains of life, Archaea, Bacteria, and Eukarya. Surprisingly, Artemia is the only genus known to include animals that expr…
Selection on dispersal drives evolution of metabolic capacities for energy production in female wing‐polymorphic sand field crickets, <i>Gryllus firmus</i> Open
Life history and metabolism covary, but the mechanisms and individual traits responsible for these linkages remain unresolved. Dispersal capability is a critical component of life history that is constrained by metabolic capacities for ene…
Global changes to HepG2 cell metabolism in response to galactose treatment Open
Tumor cell proliferation requires sufficient metabolic flux through the pentose phosphate pathway to meet the demand for biosynthetic precursors and to increase protection against oxidative stress which in turn requires an upregulation of …
Liquid-liquid phase separation promotes animal desiccation tolerance Open
Significance Recent research has shown that intracellular proteinaceous condensates (membraneless organelles [MLOs]) are involved in various processes, ranging from Alzheimer’s disease to RNA processing, and here we demonstrate that this p…
Ultrasound-induced molecular delivery to erythrocytes using a microfluidic system Open
Preservation of erythrocytes in a desiccated state for storage at ambient temperature could simplify blood transfusions in austere environments, such as rural clinics, far-forward military operations, and during space travel. Currently, st…
Sonoporation-mediated loading of trehalose in cells for cryopreservation. Open
Trehalose, a non-reducing disaccharide, is present in many microorganisms and metazoans. In these organisms, trehalose acts as a stress protectant and helps preserve lipid membranes of cells during states of desiccation and freezing. Treha…
New insights into anhydrobiosis using cellular dielectrophoresis-based characterization Open
Late embryogenesis abundant (LEA) proteins are found in desiccation-tolerant species from all domains of life. Despite several decades of investigation, the molecular mechanisms by which LEA proteins confer desiccation tolerance are still …
4-Hydroxynonenal and 4-Oxononenal Differentially Bind to the Redox Sensor MitoNEET Open
MitoNEET is a CDGSH iron-sulfur protein that has been a target for drug development for diseases such as type-2 diabetes, cancer, and Parkinson's disease. Functions proposed for mitoNEET are as a redox sensor and regulator of free iron in …
Calorespirometry: A Powerful, Noninvasive Approach to Investigate Cellular Energy Metabolism Open
Many cell lines used in basic biological and biomedical research maintain energy homeostasis through a combination of both aerobic and anaerobic respiration. However, the extent to which both pathways contribute to the landscape of cellula…